Comparative analysis of the results of surgical treatment for Peters anomaly and sclerocornea in young children
Purpose: to study and compare the results of primary penetrating keratoplasty (PKP) in young children with Peters’ anomaly and sclerocornea. Material and methods. The survival rates of the graft after primary PKP were studied in 58 children (67 eyes) under 5 years of age with congenital corneal opac...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Real Time Ltd
2025-06-01
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| Series: | Российский офтальмологический журнал |
| Subjects: | |
| Online Access: | https://roj.igb.ru/jour/article/view/1799 |
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| Summary: | Purpose: to study and compare the results of primary penetrating keratoplasty (PKP) in young children with Peters’ anomaly and sclerocornea. Material and methods. The survival rates of the graft after primary PKP were studied in 58 children (67 eyes) under 5 years of age with congenital corneal opacity in Peters’ anomaly (43 patients) and sclerocornea (15 patients). The biological result of the surgery was assessed by the Kaplan — Meier method, which was used to determine the “survival” of the graft. The functional result (taking into account the child’s age) was estimated approximately: by the child's tracking of toys from a certain distance and by the preferred gaze method. The corneal discs removed during the surgery were subjected to histological examination. Results. The overall survival rate of the grafts was 68%. Ultimately, 2 years after surgery, graft survival in children with Peters anomaly was 68%, while in children with sclerocornea it was only 20%; after 5 years, it was 56% and 7%, respectively. The mean survival time and survival rate differed significantly in patients with Peters anomaly and in patients with sclerocornea: survival time 125.3 ± 13.9 versus 36.4 ± 15.1 months (p = 0.014), survival — 82.5% versus 20.0% (p = 0.02). The presence of vascularization in the limbus and on the periphery of the cornea, as well as the diameter of the recipient’s cornea, significantly correlated with the development of graft rejection. Conclusion. After PKP, high graft survival was observed in patients aged 5 years and younger with Peters anomaly, whereas graft survival was low in patients with sclerocornea. |
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| ISSN: | 2072-0076 2587-5760 |