A simple nanoplatform of thermo-sensitive liposomes and gold nanorods to treat bone metastasis through improved chemotherapy combined with photothermal therapy
Bone metastasis remains a clinical challenge and is still considered incurable. While nanoparticles-based drug delivery and photothermal therapy (PTT) show promise in treating subcutaneous solid tumor, their therapeutic outcome in treating bone metastasis is limited, due to the inaccessibility of bo...
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Elsevier
2024-12-01
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| Series: | International Journal of Pharmaceutics: X |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590156724000549 |
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| author | Jia Gu Lifan Jiang Zhongping Chen Jun Qi |
| author_facet | Jia Gu Lifan Jiang Zhongping Chen Jun Qi |
| author_sort | Jia Gu |
| collection | DOAJ |
| description | Bone metastasis remains a clinical challenge and is still considered incurable. While nanoparticles-based drug delivery and photothermal therapy (PTT) show promise in treating subcutaneous solid tumor, their therapeutic outcome in treating bone metastasis is limited, due to the inaccessibility of bone metastatic site and the complexity of bone metastasis. Herein, we reported a simple nanoplatform composed of thermo-sensitive liposomes (TSL) and gold nanorods (GNR) to treat bone metastasis through improved chemotherapy combined with GNR-assisted PTT. Lipid combination of TSL was firstly tailored to regulate its stability under physiological condition as well as its sensitivity in responding to PTT-caused mild hyperthermia. The obtained TSL with loaded drug was then combined with GNR to form the nanoplatform through unsophisticated incubation. Cell experiments revealed that upon near-infrared (NIR) irradiation, the nanoplatform effectively inhibited the viability and migration ability of tumor cells through PTT, PTT-triggered thermo-sensitive drug release, and PTT-augmented sensitivity of tumor cells to drug. In a murine model of bone metastasis, the nanoplatform enabled effective delivery of loaded drug and GNR to bone metastatic site for rapid drug release upon local NIR irradiation. Through killing tumor cells and rebalancing the turnover of osteoclasts and osteoblasts, the nanoplatform largely preserved bone structure for pain relief and survival extension. Inspired by the simplicity of nanoplatform acquirement and treatment operation, the strategy of liposomes-based thermo-sensitive drug delivery in combination with GNR-assisted PTT is considered greatly promising in treating bone metastasis. |
| format | Article |
| id | doaj-art-0824d08d5baa47bea2f54039fda238fe |
| institution | OA Journals |
| issn | 2590-1567 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Pharmaceutics: X |
| spelling | doaj-art-0824d08d5baa47bea2f54039fda238fe2025-08-20T02:36:35ZengElsevierInternational Journal of Pharmaceutics: X2590-15672024-12-01810028210.1016/j.ijpx.2024.100282A simple nanoplatform of thermo-sensitive liposomes and gold nanorods to treat bone metastasis through improved chemotherapy combined with photothermal therapyJia Gu0Lifan Jiang1Zhongping Chen2Jun Qi3Department of Burns and Plastic Surgery, Affiliated Hospital of Nantong University, Nantong, People's Republic of China; Institute of Special Environmental Medicine, Nantong University, Nantong, People's Republic of ChinaDepartment of Burns and Plastic Surgery, Affiliated Hospital of Nantong University, Nantong, People's Republic of ChinaInstitute of Special Environmental Medicine, Nantong University, Nantong, People's Republic of China; Corresponding authors.Department of Burns and Plastic Surgery, Affiliated Hospital of Nantong University, Nantong, People's Republic of China; Corresponding authors.Bone metastasis remains a clinical challenge and is still considered incurable. While nanoparticles-based drug delivery and photothermal therapy (PTT) show promise in treating subcutaneous solid tumor, their therapeutic outcome in treating bone metastasis is limited, due to the inaccessibility of bone metastatic site and the complexity of bone metastasis. Herein, we reported a simple nanoplatform composed of thermo-sensitive liposomes (TSL) and gold nanorods (GNR) to treat bone metastasis through improved chemotherapy combined with GNR-assisted PTT. Lipid combination of TSL was firstly tailored to regulate its stability under physiological condition as well as its sensitivity in responding to PTT-caused mild hyperthermia. The obtained TSL with loaded drug was then combined with GNR to form the nanoplatform through unsophisticated incubation. Cell experiments revealed that upon near-infrared (NIR) irradiation, the nanoplatform effectively inhibited the viability and migration ability of tumor cells through PTT, PTT-triggered thermo-sensitive drug release, and PTT-augmented sensitivity of tumor cells to drug. In a murine model of bone metastasis, the nanoplatform enabled effective delivery of loaded drug and GNR to bone metastatic site for rapid drug release upon local NIR irradiation. Through killing tumor cells and rebalancing the turnover of osteoclasts and osteoblasts, the nanoplatform largely preserved bone structure for pain relief and survival extension. Inspired by the simplicity of nanoplatform acquirement and treatment operation, the strategy of liposomes-based thermo-sensitive drug delivery in combination with GNR-assisted PTT is considered greatly promising in treating bone metastasis.http://www.sciencedirect.com/science/article/pii/S2590156724000549LiposomesSensitive releaseGold nanorodsPhotothermal therapyBone metastasis |
| spellingShingle | Jia Gu Lifan Jiang Zhongping Chen Jun Qi A simple nanoplatform of thermo-sensitive liposomes and gold nanorods to treat bone metastasis through improved chemotherapy combined with photothermal therapy International Journal of Pharmaceutics: X Liposomes Sensitive release Gold nanorods Photothermal therapy Bone metastasis |
| title | A simple nanoplatform of thermo-sensitive liposomes and gold nanorods to treat bone metastasis through improved chemotherapy combined with photothermal therapy |
| title_full | A simple nanoplatform of thermo-sensitive liposomes and gold nanorods to treat bone metastasis through improved chemotherapy combined with photothermal therapy |
| title_fullStr | A simple nanoplatform of thermo-sensitive liposomes and gold nanorods to treat bone metastasis through improved chemotherapy combined with photothermal therapy |
| title_full_unstemmed | A simple nanoplatform of thermo-sensitive liposomes and gold nanorods to treat bone metastasis through improved chemotherapy combined with photothermal therapy |
| title_short | A simple nanoplatform of thermo-sensitive liposomes and gold nanorods to treat bone metastasis through improved chemotherapy combined with photothermal therapy |
| title_sort | simple nanoplatform of thermo sensitive liposomes and gold nanorods to treat bone metastasis through improved chemotherapy combined with photothermal therapy |
| topic | Liposomes Sensitive release Gold nanorods Photothermal therapy Bone metastasis |
| url | http://www.sciencedirect.com/science/article/pii/S2590156724000549 |
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