Macrophage Migration Inhibitory Factor: Critical Role in Obesity, Insulin Resistance, and Associated Comorbidities
Obesity is associated with insulin resistance, disturbed glucose homeostasis, low grade inflammation, and comorbidities such as type 2 diabetes and cardiovascular disease. The cytokine macrophage migration inhibitory factor (MIF) is an ubiquitously expressed protein that plays a crucial role in many...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2010/610479 |
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| _version_ | 1849305187848552448 |
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| author | Robert Kleemann Richard Bucala |
| author_facet | Robert Kleemann Richard Bucala |
| author_sort | Robert Kleemann |
| collection | DOAJ |
| description | Obesity is associated with insulin resistance, disturbed glucose homeostasis, low grade inflammation, and comorbidities such as type 2 diabetes and cardiovascular disease. The cytokine macrophage migration inhibitory factor (MIF) is an ubiquitously expressed protein that plays a crucial role in many inflammatory and autoimmune disorders. Increasing evidence suggests that MIF also controls metabolic and inflammatory processes underlying the development of metabolic pathologies associated with obesity. This is a comprehensive summary of our current knowledge on the role of MIF in obesity and obesity-associated comorbidities, based on human clinical data as well as animal models of disease. |
| format | Article |
| id | doaj-art-08233810bc9e4da9a4ca6e232ed37c2c |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-08233810bc9e4da9a4ca6e232ed37c2c2025-08-20T03:55:32ZengWileyMediators of Inflammation0962-93511466-18612010-01-01201010.1155/2010/610479610479Macrophage Migration Inhibitory Factor: Critical Role in Obesity, Insulin Resistance, and Associated ComorbiditiesRobert Kleemann0Richard Bucala1Department of Biosciences, Gaubius Laboratory, TNO-Quality of Life, Zernikedreef 9, 2301 CE Leiden, The NetherlandsDepartment of Medicine and Pathology, School of Medicine, Yale University, New Haven, CT 06510, USAObesity is associated with insulin resistance, disturbed glucose homeostasis, low grade inflammation, and comorbidities such as type 2 diabetes and cardiovascular disease. The cytokine macrophage migration inhibitory factor (MIF) is an ubiquitously expressed protein that plays a crucial role in many inflammatory and autoimmune disorders. Increasing evidence suggests that MIF also controls metabolic and inflammatory processes underlying the development of metabolic pathologies associated with obesity. This is a comprehensive summary of our current knowledge on the role of MIF in obesity and obesity-associated comorbidities, based on human clinical data as well as animal models of disease.http://dx.doi.org/10.1155/2010/610479 |
| spellingShingle | Robert Kleemann Richard Bucala Macrophage Migration Inhibitory Factor: Critical Role in Obesity, Insulin Resistance, and Associated Comorbidities Mediators of Inflammation |
| title | Macrophage Migration Inhibitory Factor: Critical Role in Obesity, Insulin Resistance, and Associated Comorbidities |
| title_full | Macrophage Migration Inhibitory Factor: Critical Role in Obesity, Insulin Resistance, and Associated Comorbidities |
| title_fullStr | Macrophage Migration Inhibitory Factor: Critical Role in Obesity, Insulin Resistance, and Associated Comorbidities |
| title_full_unstemmed | Macrophage Migration Inhibitory Factor: Critical Role in Obesity, Insulin Resistance, and Associated Comorbidities |
| title_short | Macrophage Migration Inhibitory Factor: Critical Role in Obesity, Insulin Resistance, and Associated Comorbidities |
| title_sort | macrophage migration inhibitory factor critical role in obesity insulin resistance and associated comorbidities |
| url | http://dx.doi.org/10.1155/2010/610479 |
| work_keys_str_mv | AT robertkleemann macrophagemigrationinhibitoryfactorcriticalroleinobesityinsulinresistanceandassociatedcomorbidities AT richardbucala macrophagemigrationinhibitoryfactorcriticalroleinobesityinsulinresistanceandassociatedcomorbidities |