THE EFFICTIVENESS OF LOW LEVEL LASER THERAPY FOR PROVENTION AND TREATMENT OF RADIATION-INDUCEED MUCO
Oral mucositis is the most common and significant complication of chemoradiation therapy for oral and pharyngeal cancer. There are no standard methods for preventing and treating this disease. Patients with severe adverse events need expensive supportive care and unplanned treatment breaks. The obje...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Russian Academy of Sciences, Tomsk National Research Medical Center
2018-05-01
|
| Series: | Сибирский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.siboncoj.ru/jour/article/view/709 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849408377171476480 |
|---|---|
| author | E. S. Sedova V. I. Jusupov N. N. Vorobjeva N. V. Kanischeva A. V. Maslennikova |
| author_facet | E. S. Sedova V. I. Jusupov N. N. Vorobjeva N. V. Kanischeva A. V. Maslennikova |
| author_sort | E. S. Sedova |
| collection | DOAJ |
| description | Oral mucositis is the most common and significant complication of chemoradiation therapy for oral and pharyngeal cancer. There are no standard methods for preventing and treating this disease. Patients with severe adverse events need expensive supportive care and unplanned treatment breaks. The objective of the study was to assess and optimize the effectiveness of low level laser therapy (LLLT) for prevention and treatment of chemoradiation-induced oral mucositis in patients with oral and pharyngeal cancer. Material and Methods. Forty-eight patients who received chemoradiation therapy for oral and pharyngeal cancer were enrolled. All patients were randomly divided into two groups. Group I patients (n=28) received standard treatment of chemoradiation-induced complications. Group II patients (n=20) were treated with low level laser therapy (LLLT) at a wavelength of 635 nm, three times a week for three minutes prior to radiation therapy session. Results. In the LLLT group, a statistically significant decrease in the frequency and severity of oral mucositis as well as decrease in pain were observed as compared to the group with standard treatment (χ2 =64,14, р<0,0001). No significant difference in the onset of symptoms and duration of severe mucositis were found. LLLT is an effective method capable of decreasing the frequency and severity of adverse events associated with concurrent chemoradiation therapy. Key words: radiation-induced mucositis, oral and pharyngeal cancer, low level laser therapy, chemoradiation therapy.><0,0001). No significant difference in the onset of symptoms and duration of severe mucositis were found. LLLT is an effective method capable of decreasing the frequency and severity of adverse events associated with concurrent chemoradiation therapy. |
| format | Article |
| id | doaj-art-081efccc73764b7ba485b4289eb556c3 |
| institution | Kabale University |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2018-05-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-081efccc73764b7ba485b4289eb556c32025-08-20T03:35:48ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682018-05-01172111710.21294/1814-4861-2018-17-2-11-17525THE EFFICTIVENESS OF LOW LEVEL LASER THERAPY FOR PROVENTION AND TREATMENT OF RADIATION-INDUCEED MUCOE. S. Sedova0V. I. Jusupov1N. N. Vorobjeva2N. V. Kanischeva3A. V. Maslennikova4Nizhny Novgorod State Medical Academy, Nizhny Novgorod; Nizhny Novgorod Regional Oncology Hospital, Nizhny NovgorodInstitute of Photonic Technologies, Federal Research Center Crystallography and Photonics, TroitskInstitute of Photonic Technologies, Federal Research Center Crystallography and Photonics, TroitskNizhny Novgorod State Medical Academy, Nizhny Novgorod; Nizhny Novgorod Regional Oncology Hospital, Nizhny NovgorodNizhny Novgorod State Medical Academy, Nizhny Novgorod; Nizhny Novgorod Regional Oncology Hospital, Nizhny NovgorodOral mucositis is the most common and significant complication of chemoradiation therapy for oral and pharyngeal cancer. There are no standard methods for preventing and treating this disease. Patients with severe adverse events need expensive supportive care and unplanned treatment breaks. The objective of the study was to assess and optimize the effectiveness of low level laser therapy (LLLT) for prevention and treatment of chemoradiation-induced oral mucositis in patients with oral and pharyngeal cancer. Material and Methods. Forty-eight patients who received chemoradiation therapy for oral and pharyngeal cancer were enrolled. All patients were randomly divided into two groups. Group I patients (n=28) received standard treatment of chemoradiation-induced complications. Group II patients (n=20) were treated with low level laser therapy (LLLT) at a wavelength of 635 nm, three times a week for three minutes prior to radiation therapy session. Results. In the LLLT group, a statistically significant decrease in the frequency and severity of oral mucositis as well as decrease in pain were observed as compared to the group with standard treatment (χ2 =64,14, р<0,0001). No significant difference in the onset of symptoms and duration of severe mucositis were found. LLLT is an effective method capable of decreasing the frequency and severity of adverse events associated with concurrent chemoradiation therapy. Key words: radiation-induced mucositis, oral and pharyngeal cancer, low level laser therapy, chemoradiation therapy.><0,0001). No significant difference in the onset of symptoms and duration of severe mucositis were found. LLLT is an effective method capable of decreasing the frequency and severity of adverse events associated with concurrent chemoradiation therapy.https://www.siboncoj.ru/jour/article/view/709radiation-induced mucositisoral and pharyngeal cancerlow level laser therapychemoradiation therapy |
| spellingShingle | E. S. Sedova V. I. Jusupov N. N. Vorobjeva N. V. Kanischeva A. V. Maslennikova THE EFFICTIVENESS OF LOW LEVEL LASER THERAPY FOR PROVENTION AND TREATMENT OF RADIATION-INDUCEED MUCO Сибирский онкологический журнал radiation-induced mucositis oral and pharyngeal cancer low level laser therapy chemoradiation therapy |
| title | THE EFFICTIVENESS OF LOW LEVEL LASER THERAPY FOR PROVENTION AND TREATMENT OF RADIATION-INDUCEED MUCO |
| title_full | THE EFFICTIVENESS OF LOW LEVEL LASER THERAPY FOR PROVENTION AND TREATMENT OF RADIATION-INDUCEED MUCO |
| title_fullStr | THE EFFICTIVENESS OF LOW LEVEL LASER THERAPY FOR PROVENTION AND TREATMENT OF RADIATION-INDUCEED MUCO |
| title_full_unstemmed | THE EFFICTIVENESS OF LOW LEVEL LASER THERAPY FOR PROVENTION AND TREATMENT OF RADIATION-INDUCEED MUCO |
| title_short | THE EFFICTIVENESS OF LOW LEVEL LASER THERAPY FOR PROVENTION AND TREATMENT OF RADIATION-INDUCEED MUCO |
| title_sort | effictiveness of low level laser therapy for provention and treatment of radiation induceed muco |
| topic | radiation-induced mucositis oral and pharyngeal cancer low level laser therapy chemoradiation therapy |
| url | https://www.siboncoj.ru/jour/article/view/709 |
| work_keys_str_mv | AT essedova theeffictivenessoflowlevellasertherapyforproventionandtreatmentofradiationinduceedmuco AT vijusupov theeffictivenessoflowlevellasertherapyforproventionandtreatmentofradiationinduceedmuco AT nnvorobjeva theeffictivenessoflowlevellasertherapyforproventionandtreatmentofradiationinduceedmuco AT nvkanischeva theeffictivenessoflowlevellasertherapyforproventionandtreatmentofradiationinduceedmuco AT avmaslennikova theeffictivenessoflowlevellasertherapyforproventionandtreatmentofradiationinduceedmuco AT essedova effictivenessoflowlevellasertherapyforproventionandtreatmentofradiationinduceedmuco AT vijusupov effictivenessoflowlevellasertherapyforproventionandtreatmentofradiationinduceedmuco AT nnvorobjeva effictivenessoflowlevellasertherapyforproventionandtreatmentofradiationinduceedmuco AT nvkanischeva effictivenessoflowlevellasertherapyforproventionandtreatmentofradiationinduceedmuco AT avmaslennikova effictivenessoflowlevellasertherapyforproventionandtreatmentofradiationinduceedmuco |