Nematocidal Potential of Synthetic Phenyl Azide Derivatives Against False Root-Knot Nematode (<i>Nacobbus aberrans</i>) Under In Vitro Conditions
The primary strategy for managing Nacobbus aberrans has traditionally relied on synthetic chemicals. However, increasing regulatory pressure on unsafe products has led to a growing research focus on nematicides. Despite this, chemical nematicides remain more effective than other control methods. Con...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-03-01
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| Series: | Agriculture |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0472/15/7/688 |
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| Summary: | The primary strategy for managing Nacobbus aberrans has traditionally relied on synthetic chemicals. However, increasing regulatory pressure on unsafe products has led to a growing research focus on nematicides. Despite this, chemical nematicides remain more effective than other control methods. Consequently, there is a pressing need to develop novel nematicides that are both effective and environmentally safer. This study aimed to evaluate the nematocidal efficacy of various synthetic molecules against the second-stage juveniles of <i>N. aberrans</i>, the false root-knot nematode. A total of fifty-eight synthetic derivatives were obtained and tested in vitro at a concentration of 500 µg/mL. The results identified the AGAz family as the most promising, with AGAz-3 (LC<sub>50</sub>: 52.7 µg/mL) and AGAz-4 (LC<sub>50</sub>: 103.22 µg/mL) surpassing the efficacy of chitosan. Our findings emphasize the strong potential of AGAz-3 and AGAz-4 as nematocidal agents, particularly for in situ applications in agricultural settings. Additionally, AGAz-3 demonstrates potential not only as a nematocidal agent but also as an incentive for related research exploring its analogs as effective ovicidal compounds and investigating its efficacy against other phytonematodes. Furthermore, compounds from the <i>N</i>-Sulfonyl-hydrazone and <i>N</i>-acyl-hydrazone series showed efficacy (>50%), warranting additional experiments to assess their effectiveness across the most important pest phytonematodes. |
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| ISSN: | 2077-0472 |