Research progress on the at-risk category and stage 0 of medication-related osteonecrosis of the jaw
Medication-related osteonecrosis of the jaw (MRONJ) is a metabolic disorder and a form of jaw osteonecrosis that arises from the use of bisphosphonates, anti-angiogenic drugs, and other medications in the treatment of conditions such as malignant tumor bone metastasis and osteoporosis. The American...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Oral and Maxillofacial Surgery
2025-02-01
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| Series: | Kouqiang hemian waike zazhi |
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| Online Access: | https://journal06.magtech.org.cn/Jweb_joms/EN/10.12439/kqhm.1005-4979.2025.01.009 |
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| _version_ | 1849224998974128128 |
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| author | YANG Mu KANG Feiwu ZHANG Xueming |
| author_facet | YANG Mu KANG Feiwu ZHANG Xueming |
| author_sort | YANG Mu |
| collection | DOAJ |
| description | Medication-related osteonecrosis of the jaw (MRONJ) is a metabolic disorder and a form of jaw osteonecrosis that arises from the use of bisphosphonates, anti-angiogenic drugs, and other medications in the treatment of conditions such as malignant tumor bone metastasis and osteoporosis. The American Association of Oral and Maxillofacial Surgeons (AAOMS) has categorized MRONJ into five stages based on clinical manifestations. Within this classification, the at-risk category encompasses asymptomatic patients who have received intravenous or oral antiresorptive therapy but show no apparent necrotic bone. Stage 0 refers to patients who exhibit no clinical evidence of necrotic bone yet present with nonspecific symptoms or clinical and radiographic findings. Presently, the diagnosis and treatment of stage 0 MRONJ still exhibit uncertainties. There is controversy regarding the effective prevention of progression from at-risk and stage 0 patients to established MRONJ. This article reviews the diagnostic approaches and current treatment status of stage 0 MRONJ, analyzes the clinical practices and research findings concerning invasive oral procedures for at-risk patients, and highlights the controversies and uncertainties within the current research field. The aim is to provide valuable insights and references for future scientific research and clinical practice. |
| format | Article |
| id | doaj-art-081586c35d094f6b9df569c1c6d8d893 |
| institution | Kabale University |
| issn | 1005-4979 |
| language | zho |
| publishDate | 2025-02-01 |
| publisher | Editorial Office of Journal of Oral and Maxillofacial Surgery |
| record_format | Article |
| series | Kouqiang hemian waike zazhi |
| spelling | doaj-art-081586c35d094f6b9df569c1c6d8d8932025-08-25T06:12:00ZzhoEditorial Office of Journal of Oral and Maxillofacial SurgeryKouqiang hemian waike zazhi1005-49792025-02-01351535810.12439/kqhm.1005-4979.2025.01.009Research progress on the at-risk category and stage 0 of medication-related osteonecrosis of the jawYANG Mu0KANG Feiwu1ZHANG Xueming2Shanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Oral and Maxillofacial Surgery, Shanghai Tongji Stomatological Hospital and Dental School, Tongji University, Shanghai 200072, ChinaShanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Oral and Maxillofacial Surgery, Shanghai Tongji Stomatological Hospital and Dental School, Tongji University, Shanghai 200072, ChinaShanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Oral and Maxillofacial Surgery, Shanghai Tongji Stomatological Hospital and Dental School, Tongji University, Shanghai 200072, ChinaMedication-related osteonecrosis of the jaw (MRONJ) is a metabolic disorder and a form of jaw osteonecrosis that arises from the use of bisphosphonates, anti-angiogenic drugs, and other medications in the treatment of conditions such as malignant tumor bone metastasis and osteoporosis. The American Association of Oral and Maxillofacial Surgeons (AAOMS) has categorized MRONJ into five stages based on clinical manifestations. Within this classification, the at-risk category encompasses asymptomatic patients who have received intravenous or oral antiresorptive therapy but show no apparent necrotic bone. Stage 0 refers to patients who exhibit no clinical evidence of necrotic bone yet present with nonspecific symptoms or clinical and radiographic findings. Presently, the diagnosis and treatment of stage 0 MRONJ still exhibit uncertainties. There is controversy regarding the effective prevention of progression from at-risk and stage 0 patients to established MRONJ. This article reviews the diagnostic approaches and current treatment status of stage 0 MRONJ, analyzes the clinical practices and research findings concerning invasive oral procedures for at-risk patients, and highlights the controversies and uncertainties within the current research field. The aim is to provide valuable insights and references for future scientific research and clinical practice.https://journal06.magtech.org.cn/Jweb_joms/EN/10.12439/kqhm.1005-4979.2025.01.009medication-related osteonecrosis of the jawbone-modifying agentsoral complicationsdiagnosispreventiontreatment |
| spellingShingle | YANG Mu KANG Feiwu ZHANG Xueming Research progress on the at-risk category and stage 0 of medication-related osteonecrosis of the jaw Kouqiang hemian waike zazhi medication-related osteonecrosis of the jaw bone-modifying agents oral complications diagnosis prevention treatment |
| title | Research progress on the at-risk category and stage 0 of medication-related osteonecrosis of the jaw |
| title_full | Research progress on the at-risk category and stage 0 of medication-related osteonecrosis of the jaw |
| title_fullStr | Research progress on the at-risk category and stage 0 of medication-related osteonecrosis of the jaw |
| title_full_unstemmed | Research progress on the at-risk category and stage 0 of medication-related osteonecrosis of the jaw |
| title_short | Research progress on the at-risk category and stage 0 of medication-related osteonecrosis of the jaw |
| title_sort | research progress on the at risk category and stage 0 of medication related osteonecrosis of the jaw |
| topic | medication-related osteonecrosis of the jaw bone-modifying agents oral complications diagnosis prevention treatment |
| url | https://journal06.magtech.org.cn/Jweb_joms/EN/10.12439/kqhm.1005-4979.2025.01.009 |
| work_keys_str_mv | AT yangmu researchprogressontheatriskcategoryandstage0ofmedicationrelatedosteonecrosisofthejaw AT kangfeiwu researchprogressontheatriskcategoryandstage0ofmedicationrelatedosteonecrosisofthejaw AT zhangxueming researchprogressontheatriskcategoryandstage0ofmedicationrelatedosteonecrosisofthejaw |