Granulocytic Sarcoma by AML M4eo (inv16) after Allogeneic Stem Cell Transplantation without Bone Marrow Involvement
Granulocytic sarcoma (GS) represents a rare type of extramedullar manifestation from the acute myeloid leukaemia (AML). We report the case of a patient with recurrences of AML M4eo leukaemia in the uterus and the small intestine at 3 and 5 years, respectively, after matched related peripheral blood...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2011/692982 |
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| author | Stephan Zaenker Stefan Schweyer Justin Hasenkamp Lorenz Truemper Gerald Wulf |
| author_facet | Stephan Zaenker Stefan Schweyer Justin Hasenkamp Lorenz Truemper Gerald Wulf |
| author_sort | Stephan Zaenker |
| collection | DOAJ |
| description | Granulocytic sarcoma (GS) represents a rare type of extramedullar manifestation from the acute myeloid leukaemia (AML). We report the case of a patient with recurrences of AML M4eo leukaemia in the uterus and the small intestine at 3 and 5 years, respectively, after matched related peripheral blood stem cell transplantation (PBSCT). The patient underwent the withdrawal of immunosuppression, hysterectomy, and local irradiation at first relapse, as well as systemic chemotherapy and donor lymphocyte infusions at second recurrence, inducing a second and third complete remission, respectively. At year six after transplantation, the patient experienced disease progression by meningeosis leukaemia to which she succumbed despite intrathecal chemotherapy. Following allogeneic stem cell transplantation, awareness for atypical manifestations of granulocytic sarcoma appears prudent, the cellular immunotherapy should aim at immunological disease control. |
| format | Article |
| id | doaj-art-0811007bc31d4546a254a29fd17b4f2a |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-0811007bc31d4546a254a29fd17b4f2a2025-02-03T01:27:14ZengWileyCase Reports in Hematology2090-65602090-65792011-01-01201110.1155/2011/692982692982Granulocytic Sarcoma by AML M4eo (inv16) after Allogeneic Stem Cell Transplantation without Bone Marrow InvolvementStephan Zaenker0Stefan Schweyer1Justin Hasenkamp2Lorenz Truemper3Gerald Wulf4Department of Haematology/Oncology, University Medicine Goettingen, Robert-Koch-Street 40, 37075 Goettingen, GermanyCenter of Pathology, University Medicine Goettingen, Robert-Koch-Street 40, 37075 Goettingen, GermanyDepartment of Haematology/Oncology, University Medicine Goettingen, Robert-Koch-Street 40, 37075 Goettingen, GermanyDepartment of Haematology/Oncology, University Medicine Goettingen, Robert-Koch-Street 40, 37075 Goettingen, GermanyDepartment of Haematology/Oncology, University Medicine Goettingen, Robert-Koch-Street 40, 37075 Goettingen, GermanyGranulocytic sarcoma (GS) represents a rare type of extramedullar manifestation from the acute myeloid leukaemia (AML). We report the case of a patient with recurrences of AML M4eo leukaemia in the uterus and the small intestine at 3 and 5 years, respectively, after matched related peripheral blood stem cell transplantation (PBSCT). The patient underwent the withdrawal of immunosuppression, hysterectomy, and local irradiation at first relapse, as well as systemic chemotherapy and donor lymphocyte infusions at second recurrence, inducing a second and third complete remission, respectively. At year six after transplantation, the patient experienced disease progression by meningeosis leukaemia to which she succumbed despite intrathecal chemotherapy. Following allogeneic stem cell transplantation, awareness for atypical manifestations of granulocytic sarcoma appears prudent, the cellular immunotherapy should aim at immunological disease control.http://dx.doi.org/10.1155/2011/692982 |
| spellingShingle | Stephan Zaenker Stefan Schweyer Justin Hasenkamp Lorenz Truemper Gerald Wulf Granulocytic Sarcoma by AML M4eo (inv16) after Allogeneic Stem Cell Transplantation without Bone Marrow Involvement Case Reports in Hematology |
| title | Granulocytic Sarcoma by AML M4eo (inv16) after Allogeneic Stem Cell Transplantation without Bone Marrow Involvement |
| title_full | Granulocytic Sarcoma by AML M4eo (inv16) after Allogeneic Stem Cell Transplantation without Bone Marrow Involvement |
| title_fullStr | Granulocytic Sarcoma by AML M4eo (inv16) after Allogeneic Stem Cell Transplantation without Bone Marrow Involvement |
| title_full_unstemmed | Granulocytic Sarcoma by AML M4eo (inv16) after Allogeneic Stem Cell Transplantation without Bone Marrow Involvement |
| title_short | Granulocytic Sarcoma by AML M4eo (inv16) after Allogeneic Stem Cell Transplantation without Bone Marrow Involvement |
| title_sort | granulocytic sarcoma by aml m4eo inv16 after allogeneic stem cell transplantation without bone marrow involvement |
| url | http://dx.doi.org/10.1155/2011/692982 |
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