Adolescent morphine exposure induced long-term cognitive impairment and prefrontal neurostructural abnormality in adulthood in male mice

Adolescent morphine exposure induced long-term cognitive impairment and prefrontal neurostructural abnormality in adulthood in male mice

Opioids abuse in adolescence is becoming a pressing public health issue. While evidence suggests that exposure to opioids during adolescence leads to lasting alterations in brain development, the long-term cognitive implications in adulthood remain uncertain. We developed a male mouse model of adole...

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Bibliographic Details
Main Authors: Ye Lu, Yijie Guo, Lulu Sun, Tong Liu, Ziqing Dong, Min Jia, Lixia Zhuo, Fangyuan Yin, Yongsheng Zhu, Xiancang Ma, Yunpeng Wang
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Heliyon
Subjects:
Adolescence
Morphine
Cognition
Memory
Medial prefrontal cortex
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024168132
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