Adolescent morphine exposure induced long-term cognitive impairment and prefrontal neurostructural abnormality in adulthood in male mice
Opioids abuse in adolescence is becoming a pressing public health issue. While evidence suggests that exposure to opioids during adolescence leads to lasting alterations in brain development, the long-term cognitive implications in adulthood remain uncertain. We developed a male mouse model of adole...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024168132 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850244872585347072 |
|---|---|
| author | Ye Lu Yijie Guo Lulu Sun Tong Liu Ziqing Dong Min Jia Lixia Zhuo Fangyuan Yin Yongsheng Zhu Xiancang Ma Yunpeng Wang |
| author_facet | Ye Lu Yijie Guo Lulu Sun Tong Liu Ziqing Dong Min Jia Lixia Zhuo Fangyuan Yin Yongsheng Zhu Xiancang Ma Yunpeng Wang |
| author_sort | Ye Lu |
| collection | DOAJ |
| description | Opioids abuse in adolescence is becoming a pressing public health issue. While evidence suggests that exposure to opioids during adolescence leads to lasting alterations in brain development, the long-term cognitive implications in adulthood remain uncertain. We developed a male mouse model of adolescent morphine exposure and used the 5-choice serial reaction time task (5‐CSRTT), along with the open field, novel object recognition, Y maze and Barnes maze tests, to assess changes in cognitive behavior. We found that exposure to morphine during adolescence led to deficits in multidimensional cognitive functions in mice, including attention, information processing speed, and behavior inhibition. Notable, these impairments persisted into adulthood. Furthermore, the morphine-exposed mice exhibited decreased learning efficiency and spatial memory. Adolescent morphine exposure also induced significant and persistent morphological changes and synaptic abnormalities in medial prefrontal cortex (mPFC) neurons, which may be responsible for cognitive impairments in adulthood. Together, our study suggests that opioid exposure during adolescence profoundly affects cognitive development and emphasizes that opioid-induced disruption of neurons in adolescence may link mPFC-associated cognitive impairments in adulthood. |
| format | Article |
| id | doaj-art-080e1bd6025b4afaa93571a779aacdb3 |
| institution | OA Journals |
| issn | 2405-8440 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-080e1bd6025b4afaa93571a779aacdb32025-08-20T01:59:38ZengElsevierHeliyon2405-84402024-12-011023e4078210.1016/j.heliyon.2024.e40782Adolescent morphine exposure induced long-term cognitive impairment and prefrontal neurostructural abnormality in adulthood in male miceYe Lu0Yijie Guo1Lulu Sun2Tong Liu3Ziqing Dong4Min Jia5Lixia Zhuo6Fangyuan Yin7Yongsheng Zhu8Xiancang Ma9Yunpeng Wang10Department of Psychiatry, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China; College of Forensic Science, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China; Shaanxi Key Laboratory of Biological Psychiatry, Xi'an, Shaanxi, 710061, ChinaCollege of Forensic Science, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, ChinaSchool of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu, 211166, ChinaCollege of Forensic Science, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China; Shaanxi Key Laboratory of Biological Psychiatry, Xi'an, Shaanxi, 710061, China; Corresponding author. Department of Psychiatry, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.Department of Psychiatry, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China; Shaanxi Key Laboratory of Biological Psychiatry, Xi'an, Shaanxi, 710061, China; Lead Contact, China; Corresponding author. Department of Psychiatry, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.Opioids abuse in adolescence is becoming a pressing public health issue. While evidence suggests that exposure to opioids during adolescence leads to lasting alterations in brain development, the long-term cognitive implications in adulthood remain uncertain. We developed a male mouse model of adolescent morphine exposure and used the 5-choice serial reaction time task (5‐CSRTT), along with the open field, novel object recognition, Y maze and Barnes maze tests, to assess changes in cognitive behavior. We found that exposure to morphine during adolescence led to deficits in multidimensional cognitive functions in mice, including attention, information processing speed, and behavior inhibition. Notable, these impairments persisted into adulthood. Furthermore, the morphine-exposed mice exhibited decreased learning efficiency and spatial memory. Adolescent morphine exposure also induced significant and persistent morphological changes and synaptic abnormalities in medial prefrontal cortex (mPFC) neurons, which may be responsible for cognitive impairments in adulthood. Together, our study suggests that opioid exposure during adolescence profoundly affects cognitive development and emphasizes that opioid-induced disruption of neurons in adolescence may link mPFC-associated cognitive impairments in adulthood.http://www.sciencedirect.com/science/article/pii/S2405844024168132AdolescenceMorphineCognitionMemoryMedial prefrontal cortex |
| spellingShingle | Ye Lu Yijie Guo Lulu Sun Tong Liu Ziqing Dong Min Jia Lixia Zhuo Fangyuan Yin Yongsheng Zhu Xiancang Ma Yunpeng Wang Adolescent morphine exposure induced long-term cognitive impairment and prefrontal neurostructural abnormality in adulthood in male mice Heliyon Adolescence Morphine Cognition Memory Medial prefrontal cortex |
| title | Adolescent morphine exposure induced long-term cognitive impairment and prefrontal neurostructural abnormality in adulthood in male mice |
| title_full | Adolescent morphine exposure induced long-term cognitive impairment and prefrontal neurostructural abnormality in adulthood in male mice |
| title_fullStr | Adolescent morphine exposure induced long-term cognitive impairment and prefrontal neurostructural abnormality in adulthood in male mice |
| title_full_unstemmed | Adolescent morphine exposure induced long-term cognitive impairment and prefrontal neurostructural abnormality in adulthood in male mice |
| title_short | Adolescent morphine exposure induced long-term cognitive impairment and prefrontal neurostructural abnormality in adulthood in male mice |
| title_sort | adolescent morphine exposure induced long term cognitive impairment and prefrontal neurostructural abnormality in adulthood in male mice |
| topic | Adolescence Morphine Cognition Memory Medial prefrontal cortex |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024168132 |
| work_keys_str_mv | AT yelu adolescentmorphineexposureinducedlongtermcognitiveimpairmentandprefrontalneurostructuralabnormalityinadulthoodinmalemice AT yijieguo adolescentmorphineexposureinducedlongtermcognitiveimpairmentandprefrontalneurostructuralabnormalityinadulthoodinmalemice AT lulusun adolescentmorphineexposureinducedlongtermcognitiveimpairmentandprefrontalneurostructuralabnormalityinadulthoodinmalemice AT tongliu adolescentmorphineexposureinducedlongtermcognitiveimpairmentandprefrontalneurostructuralabnormalityinadulthoodinmalemice AT ziqingdong adolescentmorphineexposureinducedlongtermcognitiveimpairmentandprefrontalneurostructuralabnormalityinadulthoodinmalemice AT minjia adolescentmorphineexposureinducedlongtermcognitiveimpairmentandprefrontalneurostructuralabnormalityinadulthoodinmalemice AT lixiazhuo adolescentmorphineexposureinducedlongtermcognitiveimpairmentandprefrontalneurostructuralabnormalityinadulthoodinmalemice AT fangyuanyin adolescentmorphineexposureinducedlongtermcognitiveimpairmentandprefrontalneurostructuralabnormalityinadulthoodinmalemice AT yongshengzhu adolescentmorphineexposureinducedlongtermcognitiveimpairmentandprefrontalneurostructuralabnormalityinadulthoodinmalemice AT xiancangma adolescentmorphineexposureinducedlongtermcognitiveimpairmentandprefrontalneurostructuralabnormalityinadulthoodinmalemice AT yunpengwang adolescentmorphineexposureinducedlongtermcognitiveimpairmentandprefrontalneurostructuralabnormalityinadulthoodinmalemice |