The seroprevalence of anti-Histoplasma capsulatum IgG antibody among pulmonary tuberculosis patients in seven referral tuberculosis hospitals in Indonesia.
<h4>Background</h4>Histoplasma capsulatum exposure is rarely suspected in Indonesia. Pulmonary histoplasmosis can occur simultaneously with pulmonary tuberculosis (TB) or as an alternative diagnosis in clinically-diagnosed TB patients with no microbiological evidence of TB. This study ai...
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Public Library of Science (PLoS)
2023-09-01
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| Series: | PLoS Neglected Tropical Diseases |
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| author | Tutik Kusmiati Erlina Burhan Retna Indah Sugiyono Dona Arlinda Adhella Menur Naysilla Banteng Hanang Wibisono Riat El Khair Ni Wayan Candrawati Bintang Yinke Magdalena Sinaga Irawaty Djaharrudin Dewi Lokida Herman Kosasih Nugroho Harry Susanto Deni Pepy Butar Butar Robiatul Adawiyah Ayu Eka Fatril Muhammad Karyana David W Denning Retno Wahyuningsih |
| author_facet | Tutik Kusmiati Erlina Burhan Retna Indah Sugiyono Dona Arlinda Adhella Menur Naysilla Banteng Hanang Wibisono Riat El Khair Ni Wayan Candrawati Bintang Yinke Magdalena Sinaga Irawaty Djaharrudin Dewi Lokida Herman Kosasih Nugroho Harry Susanto Deni Pepy Butar Butar Robiatul Adawiyah Ayu Eka Fatril Muhammad Karyana David W Denning Retno Wahyuningsih |
| author_sort | Tutik Kusmiati |
| collection | DOAJ |
| description | <h4>Background</h4>Histoplasma capsulatum exposure is rarely suspected in Indonesia. Pulmonary histoplasmosis can occur simultaneously with pulmonary tuberculosis (TB) or as an alternative diagnosis in clinically-diagnosed TB patients with no microbiological evidence of TB. This study aimed to determine the seroprevalence of anti-H. capsulatum IgG antibody among pulmonary TB patients.<h4>Methodology</h4>This was a sub-study of 306 participants from a prospective cohort pulmonary TB study conducted at seven TB referral hospitals in Indonesia. The study population was presumptive pulmonary TB adult patients who underwent microbiological TB examinations and were categorized as drug-sensitive (DS), drug-resistant (DR), and clinically-diagnosed TB. Anti-H. capsulatum IgG antibody levels at baseline were measured using MVista Histoplasma Ab enzyme immunoassays. Data were summarized using descriptive statistics. Bivariate and multivariate logistic regression analysis were performed to assess factors associated with anti-H. capsulatum IgG antibody positive result.<h4>Results</h4>12.7% (39/306) of pulmonary TB patients were positive for anti-H. capsulatum IgG antibodies (DR-TB patients (15.9%, 18/114), DS-TB (13.0%, 15/115), and clinically-diagnosed TB (7.8%, 6/77)). The median unit value of anti-H. capsulatum IgG antibody for all positive samples was 15.7 (IQR 10.2-28.9) EU. This median unit value was higher in clinically-diagnosed TB patients compared to DS-TB or DR-TB patients (38.1 (IQR 25.6-46.6) EU, 19.7 (IQR 12.3-28.9) EU, and 10.9 (IQR 9.2-15.4), respectively). There were 10 patients (3.3%) with anti-H. capsulatum IgG antibody levels above 30 EU. Factors associated with the anti-H. capsulatum IgG antibody positive result were malignancies (OR 4.88, 95% CI 1.09-21.69, p = 0.037) and cavitary lesions (OR 2.27, 95% CI 1.09-4.70, p = 0.028).<h4>Conclusions</h4>Our results provide evidence of exposure to H. capsulatum among pulmonary TB patients in Indonesia. Further studies are needed to provide a comprehensive picture of this fungal disease in other populations and regions to enhance awareness among clinicians and public health officials. |
| format | Article |
| id | doaj-art-08086cfd4f3442af9d14e565795eba88 |
| institution | OA Journals |
| issn | 1935-2727 1935-2735 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj-art-08086cfd4f3442af9d14e565795eba882025-08-20T02:33:19ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352023-09-01179e001157510.1371/journal.pntd.0011575The seroprevalence of anti-Histoplasma capsulatum IgG antibody among pulmonary tuberculosis patients in seven referral tuberculosis hospitals in Indonesia.Tutik KusmiatiErlina BurhanRetna Indah SugiyonoDona ArlindaAdhella Menur NaysillaBanteng Hanang WibisonoRiat El KhairNi Wayan CandrawatiBintang Yinke Magdalena SinagaIrawaty DjaharrudinDewi LokidaHerman KosasihNugroho Harry SusantoDeni Pepy Butar ButarRobiatul AdawiyahAyu Eka FatrilMuhammad KaryanaDavid W DenningRetno Wahyuningsih<h4>Background</h4>Histoplasma capsulatum exposure is rarely suspected in Indonesia. Pulmonary histoplasmosis can occur simultaneously with pulmonary tuberculosis (TB) or as an alternative diagnosis in clinically-diagnosed TB patients with no microbiological evidence of TB. This study aimed to determine the seroprevalence of anti-H. capsulatum IgG antibody among pulmonary TB patients.<h4>Methodology</h4>This was a sub-study of 306 participants from a prospective cohort pulmonary TB study conducted at seven TB referral hospitals in Indonesia. The study population was presumptive pulmonary TB adult patients who underwent microbiological TB examinations and were categorized as drug-sensitive (DS), drug-resistant (DR), and clinically-diagnosed TB. Anti-H. capsulatum IgG antibody levels at baseline were measured using MVista Histoplasma Ab enzyme immunoassays. Data were summarized using descriptive statistics. Bivariate and multivariate logistic regression analysis were performed to assess factors associated with anti-H. capsulatum IgG antibody positive result.<h4>Results</h4>12.7% (39/306) of pulmonary TB patients were positive for anti-H. capsulatum IgG antibodies (DR-TB patients (15.9%, 18/114), DS-TB (13.0%, 15/115), and clinically-diagnosed TB (7.8%, 6/77)). The median unit value of anti-H. capsulatum IgG antibody for all positive samples was 15.7 (IQR 10.2-28.9) EU. This median unit value was higher in clinically-diagnosed TB patients compared to DS-TB or DR-TB patients (38.1 (IQR 25.6-46.6) EU, 19.7 (IQR 12.3-28.9) EU, and 10.9 (IQR 9.2-15.4), respectively). There were 10 patients (3.3%) with anti-H. capsulatum IgG antibody levels above 30 EU. Factors associated with the anti-H. capsulatum IgG antibody positive result were malignancies (OR 4.88, 95% CI 1.09-21.69, p = 0.037) and cavitary lesions (OR 2.27, 95% CI 1.09-4.70, p = 0.028).<h4>Conclusions</h4>Our results provide evidence of exposure to H. capsulatum among pulmonary TB patients in Indonesia. Further studies are needed to provide a comprehensive picture of this fungal disease in other populations and regions to enhance awareness among clinicians and public health officials.https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011575&type=printable |
| spellingShingle | Tutik Kusmiati Erlina Burhan Retna Indah Sugiyono Dona Arlinda Adhella Menur Naysilla Banteng Hanang Wibisono Riat El Khair Ni Wayan Candrawati Bintang Yinke Magdalena Sinaga Irawaty Djaharrudin Dewi Lokida Herman Kosasih Nugroho Harry Susanto Deni Pepy Butar Butar Robiatul Adawiyah Ayu Eka Fatril Muhammad Karyana David W Denning Retno Wahyuningsih The seroprevalence of anti-Histoplasma capsulatum IgG antibody among pulmonary tuberculosis patients in seven referral tuberculosis hospitals in Indonesia. PLoS Neglected Tropical Diseases |
| title | The seroprevalence of anti-Histoplasma capsulatum IgG antibody among pulmonary tuberculosis patients in seven referral tuberculosis hospitals in Indonesia. |
| title_full | The seroprevalence of anti-Histoplasma capsulatum IgG antibody among pulmonary tuberculosis patients in seven referral tuberculosis hospitals in Indonesia. |
| title_fullStr | The seroprevalence of anti-Histoplasma capsulatum IgG antibody among pulmonary tuberculosis patients in seven referral tuberculosis hospitals in Indonesia. |
| title_full_unstemmed | The seroprevalence of anti-Histoplasma capsulatum IgG antibody among pulmonary tuberculosis patients in seven referral tuberculosis hospitals in Indonesia. |
| title_short | The seroprevalence of anti-Histoplasma capsulatum IgG antibody among pulmonary tuberculosis patients in seven referral tuberculosis hospitals in Indonesia. |
| title_sort | seroprevalence of anti histoplasma capsulatum igg antibody among pulmonary tuberculosis patients in seven referral tuberculosis hospitals in indonesia |
| url | https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011575&type=printable |
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