A Rare Case of Acute Renal Failure Secondary to Rhabdomyolysis Probably Induced by Donepezil
Introduction. Acute renal failure (ARF) develops in 33% of the patients with rhabdomyolysis. The main etiologic factors are alcoholism, trauma, exercise overexertion, and drugs. In this report we present a rare case of ARF secondary to probably donepezil-induced rhabdomyolysis. Case Presentation. An...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2014/214359 |
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| author | Osman Zikrullah Sahin Teslime Ayaz Suleyman Yuce Fatih Sumer Serap Baydur Sahin |
| author_facet | Osman Zikrullah Sahin Teslime Ayaz Suleyman Yuce Fatih Sumer Serap Baydur Sahin |
| author_sort | Osman Zikrullah Sahin |
| collection | DOAJ |
| description | Introduction. Acute renal failure (ARF) develops in 33% of the patients with rhabdomyolysis. The main etiologic factors are alcoholism, trauma, exercise overexertion, and drugs. In this report we present a rare case of ARF secondary to probably donepezil-induced rhabdomyolysis. Case Presentation. An 84-year-old male patient was admitted to the emergency department with a complaint of generalized weakness and reduced consciousness for two days. He had a history of Alzheimer’s disease for one year and he had taken donepezil 5 mg daily for two months. The patient’s physical examination revealed apathy, loss of cooperation, and decreased muscle strength. Laboratory studies revealed the following: urea: 128 mg/dL; Creatinine 6.06 mg/dL; creatine kinase: 3613 mg/dL. Donepezil was discontinued and the patient’s renal function tests improved gradually. Conclusion. Rhabdomyolysis-induced acute renal failure may develop secondary to donepezil therapy. |
| format | Article |
| id | doaj-art-08081131c55d409d96e4fd8fa0a30b0c |
| institution | Kabale University |
| issn | 2090-6641 2090-665X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-08081131c55d409d96e4fd8fa0a30b0c2025-02-03T06:05:06ZengWileyCase Reports in Nephrology2090-66412090-665X2014-01-01201410.1155/2014/214359214359A Rare Case of Acute Renal Failure Secondary to Rhabdomyolysis Probably Induced by DonepezilOsman Zikrullah Sahin0Teslime Ayaz1Suleyman Yuce2Fatih Sumer3Serap Baydur Sahin4Department of Nephrology, Recep Tayyip Erdogan University Medical School, 53100 Rize, TurkeyDepartment of Internal Medicine, Recep Tayyip Erdogan University Medical School, 53100 Rize, TurkeyDepartment of Internal Medicine, Recep Tayyip Erdogan University Medical School, 53100 Rize, TurkeyDepartment of Internal Medicine, Recep Tayyip Erdogan University Medical School, 53100 Rize, TurkeyDepartment of Endocrinology and Metabolic Disease, Recep Tayyip Erdogan University Medical School, 53100 Rize, TurkeyIntroduction. Acute renal failure (ARF) develops in 33% of the patients with rhabdomyolysis. The main etiologic factors are alcoholism, trauma, exercise overexertion, and drugs. In this report we present a rare case of ARF secondary to probably donepezil-induced rhabdomyolysis. Case Presentation. An 84-year-old male patient was admitted to the emergency department with a complaint of generalized weakness and reduced consciousness for two days. He had a history of Alzheimer’s disease for one year and he had taken donepezil 5 mg daily for two months. The patient’s physical examination revealed apathy, loss of cooperation, and decreased muscle strength. Laboratory studies revealed the following: urea: 128 mg/dL; Creatinine 6.06 mg/dL; creatine kinase: 3613 mg/dL. Donepezil was discontinued and the patient’s renal function tests improved gradually. Conclusion. Rhabdomyolysis-induced acute renal failure may develop secondary to donepezil therapy.http://dx.doi.org/10.1155/2014/214359 |
| spellingShingle | Osman Zikrullah Sahin Teslime Ayaz Suleyman Yuce Fatih Sumer Serap Baydur Sahin A Rare Case of Acute Renal Failure Secondary to Rhabdomyolysis Probably Induced by Donepezil Case Reports in Nephrology |
| title | A Rare Case of Acute Renal Failure Secondary to Rhabdomyolysis Probably Induced by Donepezil |
| title_full | A Rare Case of Acute Renal Failure Secondary to Rhabdomyolysis Probably Induced by Donepezil |
| title_fullStr | A Rare Case of Acute Renal Failure Secondary to Rhabdomyolysis Probably Induced by Donepezil |
| title_full_unstemmed | A Rare Case of Acute Renal Failure Secondary to Rhabdomyolysis Probably Induced by Donepezil |
| title_short | A Rare Case of Acute Renal Failure Secondary to Rhabdomyolysis Probably Induced by Donepezil |
| title_sort | rare case of acute renal failure secondary to rhabdomyolysis probably induced by donepezil |
| url | http://dx.doi.org/10.1155/2014/214359 |
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