Doxorubicin and NFL-TBS.40-63 peptide loaded gold nanoparticles as a multimodal therapy of glioblastoma

Doxorubicin and NFL-TBS.40-63 peptide loaded gold nanoparticles as a multimodal therapy of glioblastoma

Abstract Conventional treatments for glioblastoma (GBM) are hindered by systemic toxicity, limited blood–brain barrier penetration, and therapeutic resistance. To address these challenges, we developed dual-functionalized gold nanoparticles (AuNPs) conjugated with a biotinylated NFL-TBS.40-63 peptid...

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Bibliographic Details
Main Authors: Myriam El Moutaoukil, Maria Grazia Lolli, Stefania D’Amone, Memona Khan, Roberta Grillo, Joel Eyer, Maddalena Grieco, Ornella Ursini, Jolanda Spadavecchia, Barbara Cortese
Format: Article
Language:English
Published: Springer 2025-04-01
Series:Discover Nano
Subjects:
Gold Nanoparticles
Dual-functionalized nanoparticles
Drug uptake enhancement
Glioblastoma
Therapeutic nanomedicine
Online Access:https://doi.org/10.1186/s11671-025-04249-z
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