Are Toll-Like Receptors and Decoy Receptors Involved in the Immunopathogenesis of Systemic Lupus Erythematosus and Lupus-Like Syndromes?
In this paper we focus our attention on the role of two families of receptors, Toll-like receptors (TLR) and decoy receptors (DcR) involved in the generation of systemic lupus erythematosus (SLE) and lupus-like syndromes in human and mouse models. To date, these molecules were described in several...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/135932 |
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| author | Giuliana Guggino Anna Rita Giardina Francesco Ciccia Giovanni Triolo Francesco Dieli Guido Sireci |
| author_facet | Giuliana Guggino Anna Rita Giardina Francesco Ciccia Giovanni Triolo Francesco Dieli Guido Sireci |
| author_sort | Giuliana Guggino |
| collection | DOAJ |
| description | In this paper we focus our attention on the role of two families of receptors, Toll-like receptors (TLR) and decoy receptors (DcR) involved in the generation of systemic lupus erythematosus (SLE) and lupus-like syndromes in human and mouse models. To date, these molecules were described in several autoimmune disorders such as rheumatoid arthritis, antiphospholipids syndrome, bowel inflammation, and SLE. Here, we summarize the findings of recent investigations on TLR and DcR and their role in the immunopathogenesis of the SLE. |
| format | Article |
| id | doaj-art-07ff8e873de64a9a93d9b3e39286487b |
| institution | OA Journals |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-07ff8e873de64a9a93d9b3e39286487b2025-08-20T02:01:39ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/135932135932Are Toll-Like Receptors and Decoy Receptors Involved in the Immunopathogenesis of Systemic Lupus Erythematosus and Lupus-Like Syndromes?Giuliana Guggino0Anna Rita Giardina1Francesco Ciccia2Giovanni Triolo3Francesco Dieli4Guido Sireci5Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, Università degli Studi di Palermo, DIBIMEF, Corso Tukory 211, 90100 Palermo, ItalyDivisione di Reumatologia, Dipartimento Biomedico di Medicina Interna e Specialistica, Università degli Studi di Palermo, 90133 Palermo, ItalyDivisione di Reumatologia, Dipartimento Biomedico di Medicina Interna e Specialistica, Università degli Studi di Palermo, 90133 Palermo, ItalyDivisione di Reumatologia, Dipartimento Biomedico di Medicina Interna e Specialistica, Università degli Studi di Palermo, 90133 Palermo, ItalyDipartimento di Biopatologia e Biotecnologie Mediche e Forensi, Università degli Studi di Palermo, DIBIMEF, Corso Tukory 211, 90100 Palermo, ItalyDipartimento di Biopatologia e Biotecnologie Mediche e Forensi, Università degli Studi di Palermo, DIBIMEF, Corso Tukory 211, 90100 Palermo, ItalyIn this paper we focus our attention on the role of two families of receptors, Toll-like receptors (TLR) and decoy receptors (DcR) involved in the generation of systemic lupus erythematosus (SLE) and lupus-like syndromes in human and mouse models. To date, these molecules were described in several autoimmune disorders such as rheumatoid arthritis, antiphospholipids syndrome, bowel inflammation, and SLE. Here, we summarize the findings of recent investigations on TLR and DcR and their role in the immunopathogenesis of the SLE.http://dx.doi.org/10.1155/2012/135932 |
| spellingShingle | Giuliana Guggino Anna Rita Giardina Francesco Ciccia Giovanni Triolo Francesco Dieli Guido Sireci Are Toll-Like Receptors and Decoy Receptors Involved in the Immunopathogenesis of Systemic Lupus Erythematosus and Lupus-Like Syndromes? Clinical and Developmental Immunology |
| title | Are Toll-Like Receptors and Decoy Receptors Involved in the Immunopathogenesis of Systemic Lupus Erythematosus and Lupus-Like Syndromes? |
| title_full | Are Toll-Like Receptors and Decoy Receptors Involved in the Immunopathogenesis of Systemic Lupus Erythematosus and Lupus-Like Syndromes? |
| title_fullStr | Are Toll-Like Receptors and Decoy Receptors Involved in the Immunopathogenesis of Systemic Lupus Erythematosus and Lupus-Like Syndromes? |
| title_full_unstemmed | Are Toll-Like Receptors and Decoy Receptors Involved in the Immunopathogenesis of Systemic Lupus Erythematosus and Lupus-Like Syndromes? |
| title_short | Are Toll-Like Receptors and Decoy Receptors Involved in the Immunopathogenesis of Systemic Lupus Erythematosus and Lupus-Like Syndromes? |
| title_sort | are toll like receptors and decoy receptors involved in the immunopathogenesis of systemic lupus erythematosus and lupus like syndromes |
| url | http://dx.doi.org/10.1155/2012/135932 |
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