Effects of Vertical Transmission and Human Contact on Zika Dynamics
The main objective of Zika transmission studies is to work out the simplest approach to scale back human mortality and morbidity caused by the disease. Therefore, it is essential to spot the relative importance of the various factors contributing to the transmission and prevalence of the disease. Ma...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Complexity |
| Online Access: | http://dx.doi.org/10.1155/2022/5366395 |
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| author | Abdoulaye Sow Cherif Diallo Hocine Cherifi |
| author_facet | Abdoulaye Sow Cherif Diallo Hocine Cherifi |
| author_sort | Abdoulaye Sow |
| collection | DOAJ |
| description | The main objective of Zika transmission studies is to work out the simplest approach to scale back human mortality and morbidity caused by the disease. Therefore, it is essential to spot the relative importance of the various factors contributing to the transmission and prevalence of the disease. Many mathematical models have been formulated incorporating vector-to-human transmission or human-to-human transmission. However, they do not take into consideration the mixture of both sorts of transmission. It raises the question of the impact of both sorts of transmission on the disease dynamics. We develop a mathematical model of Zika with the vertical transmission in the vector population and human-to-human transmission to answer this question. It includes the immature phase of mosquitoes (eggs), adult mosquitoes (susceptible, exposed, and infectious), and human hosts (susceptible, exposed, infectious, and recovered). Results show that neglecting sexual transmission results in an understatement of the proportion of the infected population. Furthermore, it reduces the speed of disease spreading. On the other hand, vertical transmission in mosquitoes has a negligible effect on the dynamics of disease spread. We perform a sensitivity analysis of the reproductive number R0 to raise to understand the parameters driving the dynamics of the disease. It appears that the most sensitive parameters in decreasing order are as follows: the adult mosquito death rate, the sting rate, the transmission probability of mosquito to human, and, therefore, the transmission probability of human to mosquito. Furthermore, the proportion at the equilibrium of infected humans is extremely sensitive to the transition rate from the immature vector stage to the adult stage, the human-to-human transmission rate, and, therefore, the human recovery rate. These results confirm that control policies targeting the vector population and, therefore, the recovery rate of people are pretty effective solutions. To validate the model and estimate the important parameters of the model and the prediction of the disease, we consider the real cases in Colombia from 2016. In a series of graphic maps, we presented the comparative study to estimate the disease scenarios and to predict the time limit of the epidemic control measure. |
| format | Article |
| id | doaj-art-07fd833a94c8431c92f91119795a0586 |
| institution | Kabale University |
| issn | 1099-0526 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Complexity |
| spelling | doaj-art-07fd833a94c8431c92f91119795a05862025-02-03T06:01:51ZengWileyComplexity1099-05262022-01-01202210.1155/2022/5366395Effects of Vertical Transmission and Human Contact on Zika DynamicsAbdoulaye Sow0Cherif Diallo1Hocine Cherifi2University Gaston BergerUniversity Gaston BergerUniversity of BurgundyThe main objective of Zika transmission studies is to work out the simplest approach to scale back human mortality and morbidity caused by the disease. Therefore, it is essential to spot the relative importance of the various factors contributing to the transmission and prevalence of the disease. Many mathematical models have been formulated incorporating vector-to-human transmission or human-to-human transmission. However, they do not take into consideration the mixture of both sorts of transmission. It raises the question of the impact of both sorts of transmission on the disease dynamics. We develop a mathematical model of Zika with the vertical transmission in the vector population and human-to-human transmission to answer this question. It includes the immature phase of mosquitoes (eggs), adult mosquitoes (susceptible, exposed, and infectious), and human hosts (susceptible, exposed, infectious, and recovered). Results show that neglecting sexual transmission results in an understatement of the proportion of the infected population. Furthermore, it reduces the speed of disease spreading. On the other hand, vertical transmission in mosquitoes has a negligible effect on the dynamics of disease spread. We perform a sensitivity analysis of the reproductive number R0 to raise to understand the parameters driving the dynamics of the disease. It appears that the most sensitive parameters in decreasing order are as follows: the adult mosquito death rate, the sting rate, the transmission probability of mosquito to human, and, therefore, the transmission probability of human to mosquito. Furthermore, the proportion at the equilibrium of infected humans is extremely sensitive to the transition rate from the immature vector stage to the adult stage, the human-to-human transmission rate, and, therefore, the human recovery rate. These results confirm that control policies targeting the vector population and, therefore, the recovery rate of people are pretty effective solutions. To validate the model and estimate the important parameters of the model and the prediction of the disease, we consider the real cases in Colombia from 2016. In a series of graphic maps, we presented the comparative study to estimate the disease scenarios and to predict the time limit of the epidemic control measure.http://dx.doi.org/10.1155/2022/5366395 |
| spellingShingle | Abdoulaye Sow Cherif Diallo Hocine Cherifi Effects of Vertical Transmission and Human Contact on Zika Dynamics Complexity |
| title | Effects of Vertical Transmission and Human Contact on Zika Dynamics |
| title_full | Effects of Vertical Transmission and Human Contact on Zika Dynamics |
| title_fullStr | Effects of Vertical Transmission and Human Contact on Zika Dynamics |
| title_full_unstemmed | Effects of Vertical Transmission and Human Contact on Zika Dynamics |
| title_short | Effects of Vertical Transmission and Human Contact on Zika Dynamics |
| title_sort | effects of vertical transmission and human contact on zika dynamics |
| url | http://dx.doi.org/10.1155/2022/5366395 |
| work_keys_str_mv | AT abdoulayesow effectsofverticaltransmissionandhumancontactonzikadynamics AT cherifdiallo effectsofverticaltransmissionandhumancontactonzikadynamics AT hocinecherifi effectsofverticaltransmissionandhumancontactonzikadynamics |