Humanizing π-class glutathione S-transferase regulation in a mouse model alters liver toxicity in response to acetaminophen overdose.

Humanizing π-class glutathione S-transferase regulation in a mouse model alters liver toxicity in response to acetaminophen overdose.

<h4>Background</h4>Glutathione S-transferases (GSTs) metabolize drugs and xenobiotics. Yet despite high protein sequence homology, expression of π-class GSTs, the most abundant of the enzymes, varies significantly between species. In mouse liver, hepatocytes exhibit high mGstp expression...

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Main Authors: Matthew P Vaughn, Debika Biswal Shinohara, Nicole Castagna, Jessica L Hicks, George Netto, Angelo M De Marzo, Traci J Speed, Zachery R Reichert, Bernard Kwabi-Addo, Colin J Henderson, C Roland Wolf, Srinivasan Yegnasubramanian, William G Nelson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0025707&type=printable
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