Role of Nampt and Visceral Adiposity in Esophagogastric Junction Adenocarcinoma
Nampt including eNampt and iNampt may contribute to mediating obesity-associated cancers. This study investigated the role of Nampt in esophagogastric junction adenocarcinoma (EGA), a cancer strongly correlated with obesity. Visceral adiposity was defined by waist circumference or VFA. eNampt in ser...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2017/3970605 |
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| author | Haijun Li E. Bai Yong Zhang Zhuoqi Jia Shicai He Junke Fu |
| author_facet | Haijun Li E. Bai Yong Zhang Zhuoqi Jia Shicai He Junke Fu |
| author_sort | Haijun Li |
| collection | DOAJ |
| description | Nampt including eNampt and iNampt may contribute to mediating obesity-associated cancers. This study investigated the role of Nampt in esophagogastric junction adenocarcinoma (EGA), a cancer strongly correlated with obesity. Visceral adiposity was defined by waist circumference or VFA. eNampt in sera were measured by enzyme-linked immunosorbent assay. iNampt expression in EGA was determined by PCR, western blot, and immunohistochemistry. Sera eNampt were significantly elevated in these overweight and obese patients, especially for viscerally obese patients, and positively correlated with BMI, waist circumference, VFA, and also primary tumor, regional lymph nodes, and TNM stage (P<0.05). iNampt expression in both the mRNA and protein levels was upregulated in EGAs (P<0.05). iNampt staining was found primarily in the cytoplasm and nuclei and significantly associated with tumor, lymph nodes, and TNM stage and also correlated positively with serum eNampt, BMI, total fat area, VFA, superficial fat area, and waist circumference (P<0.05). iNampt, eNampt, tumor, lymph nodes, and TNM stage correlated to the survival of EGAs, and iNampt expression and TNM stage affected the prognosis independently (P<0.05). This study highlighted the association of eNampt/iNampt with visceral obesity and a potential impact on the biology of EGA. |
| format | Article |
| id | doaj-art-07faeb7f86e643f099122a916ba1d44b |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-07faeb7f86e643f099122a916ba1d44b2025-08-20T03:55:27ZengWileyJournal of Immunology Research2314-88612314-71562017-01-01201710.1155/2017/39706053970605Role of Nampt and Visceral Adiposity in Esophagogastric Junction AdenocarcinomaHaijun Li0E. Bai1Yong Zhang2Zhuoqi Jia3Shicai He4Junke Fu5Department of Thoracic Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, ChinaDepartment of Gynecology and Obstetrics, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, ChinaDepartment of Thoracic Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, ChinaDepartment of Thoracic Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, ChinaDepartment of General Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, ChinaDepartment of Thoracic Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, ChinaNampt including eNampt and iNampt may contribute to mediating obesity-associated cancers. This study investigated the role of Nampt in esophagogastric junction adenocarcinoma (EGA), a cancer strongly correlated with obesity. Visceral adiposity was defined by waist circumference or VFA. eNampt in sera were measured by enzyme-linked immunosorbent assay. iNampt expression in EGA was determined by PCR, western blot, and immunohistochemistry. Sera eNampt were significantly elevated in these overweight and obese patients, especially for viscerally obese patients, and positively correlated with BMI, waist circumference, VFA, and also primary tumor, regional lymph nodes, and TNM stage (P<0.05). iNampt expression in both the mRNA and protein levels was upregulated in EGAs (P<0.05). iNampt staining was found primarily in the cytoplasm and nuclei and significantly associated with tumor, lymph nodes, and TNM stage and also correlated positively with serum eNampt, BMI, total fat area, VFA, superficial fat area, and waist circumference (P<0.05). iNampt, eNampt, tumor, lymph nodes, and TNM stage correlated to the survival of EGAs, and iNampt expression and TNM stage affected the prognosis independently (P<0.05). This study highlighted the association of eNampt/iNampt with visceral obesity and a potential impact on the biology of EGA.http://dx.doi.org/10.1155/2017/3970605 |
| spellingShingle | Haijun Li E. Bai Yong Zhang Zhuoqi Jia Shicai He Junke Fu Role of Nampt and Visceral Adiposity in Esophagogastric Junction Adenocarcinoma Journal of Immunology Research |
| title | Role of Nampt and Visceral Adiposity in Esophagogastric Junction Adenocarcinoma |
| title_full | Role of Nampt and Visceral Adiposity in Esophagogastric Junction Adenocarcinoma |
| title_fullStr | Role of Nampt and Visceral Adiposity in Esophagogastric Junction Adenocarcinoma |
| title_full_unstemmed | Role of Nampt and Visceral Adiposity in Esophagogastric Junction Adenocarcinoma |
| title_short | Role of Nampt and Visceral Adiposity in Esophagogastric Junction Adenocarcinoma |
| title_sort | role of nampt and visceral adiposity in esophagogastric junction adenocarcinoma |
| url | http://dx.doi.org/10.1155/2017/3970605 |
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