The role of polymorphism (rs1800566) of NAD(F)H quinone oxidoreductase-1 in development of acute pancreatitis
Aim of investigation. To estimate the role of genetic polymorphism (rs1800566) of NAD(F)H quinone oxidoreductase-1 in development of acute pancreatitis in the Russian population. Material and methods. Whole blood samples were received from 349 unrelated AP patients and 329 unrelated individuals of R...
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Gastro LLC
2018-08-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/213 |
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| author | T. A. Samgina Y. V. Kanishchev S. N. Grigor’Yev P. M. Nazarenko A. V. Polonikov |
| author_facet | T. A. Samgina Y. V. Kanishchev S. N. Grigor’Yev P. M. Nazarenko A. V. Polonikov |
| author_sort | T. A. Samgina |
| collection | DOAJ |
| description | Aim of investigation. To estimate the role of genetic polymorphism (rs1800566) of NAD(F)H quinone oxidoreductase-1 in development of acute pancreatitis in the Russian population. Material and methods. Whole blood samples were received from 349 unrelated AP patients and 329 unrelated individuals of Russian nationality having no gastrointestinal diseases. Mean age of patients was 48.9±13.1 years, mean age of healthy controls - 47.8±12.1 years. Genotyping of NQO1 gene polymorphism (rs1800566) was carried out by real-time polymerase chain reaction. Results. The association of polymorphism (rs1800566) of NQO1 gene T/T genotype with high risk of AP development, mostly - acute and non-biliary pancreatitis, in males. The risk of disease was elevated in patients with TT genotype irrespective of intensity and duration of alcohol intake, as well as in smoking patients with ST genotype at alcohol consumption exceeding 10 years, even in those receiving less than 199 g of ethanol per week. |
| format | Article |
| id | doaj-art-07f13b6508b942d49170933410e68c10 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2018-08-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-07f13b6508b942d49170933410e68c102025-02-10T16:14:29ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732018-08-01281202510.22416/1382-4376-2018-28-1-20-25213The role of polymorphism (rs1800566) of NAD(F)H quinone oxidoreductase-1 in development of acute pancreatitisT. A. Samgina0Y. V. Kanishchev1S. N. Grigor’Yev2P. M. Nazarenko3A. V. Polonikov4Federal state educational government-financed institution of higher education «Kursk state medical university»Federal state educational government-financed institution of higher education «Kursk state medical university»Federal state educational government-financed institution of higher education «Kursk state medical university»Federal state educational government-financed institution of higher education «Kursk state medical university»Federal state educational government-financed institution of higher education «Kursk state medical university»Aim of investigation. To estimate the role of genetic polymorphism (rs1800566) of NAD(F)H quinone oxidoreductase-1 in development of acute pancreatitis in the Russian population. Material and methods. Whole blood samples were received from 349 unrelated AP patients and 329 unrelated individuals of Russian nationality having no gastrointestinal diseases. Mean age of patients was 48.9±13.1 years, mean age of healthy controls - 47.8±12.1 years. Genotyping of NQO1 gene polymorphism (rs1800566) was carried out by real-time polymerase chain reaction. Results. The association of polymorphism (rs1800566) of NQO1 gene T/T genotype with high risk of AP development, mostly - acute and non-biliary pancreatitis, in males. The risk of disease was elevated in patients with TT genotype irrespective of intensity and duration of alcohol intake, as well as in smoking patients with ST genotype at alcohol consumption exceeding 10 years, even in those receiving less than 199 g of ethanol per week.https://www.gastro-j.ru/jour/article/view/213острый панкреатитгенетический полиморфизмнад(ф)н-хиноноксидоредуктаза 1 |
| spellingShingle | T. A. Samgina Y. V. Kanishchev S. N. Grigor’Yev P. M. Nazarenko A. V. Polonikov The role of polymorphism (rs1800566) of NAD(F)H quinone oxidoreductase-1 in development of acute pancreatitis Российский журнал гастроэнтерологии, гепатологии, колопроктологии острый панкреатит генетический полиморфизм над(ф)н-хиноноксидоредуктаза 1 |
| title | The role of polymorphism (rs1800566) of NAD(F)H quinone oxidoreductase-1 in development of acute pancreatitis |
| title_full | The role of polymorphism (rs1800566) of NAD(F)H quinone oxidoreductase-1 in development of acute pancreatitis |
| title_fullStr | The role of polymorphism (rs1800566) of NAD(F)H quinone oxidoreductase-1 in development of acute pancreatitis |
| title_full_unstemmed | The role of polymorphism (rs1800566) of NAD(F)H quinone oxidoreductase-1 in development of acute pancreatitis |
| title_short | The role of polymorphism (rs1800566) of NAD(F)H quinone oxidoreductase-1 in development of acute pancreatitis |
| title_sort | role of polymorphism rs1800566 of nad f h quinone oxidoreductase 1 in development of acute pancreatitis |
| topic | острый панкреатит генетический полиморфизм над(ф)н-хиноноксидоредуктаза 1 |
| url | https://www.gastro-j.ru/jour/article/view/213 |
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