Synergistic effects of PM2.5 components and ozone exposure on lung function in young adults: A cohort study in Shandong, China
Exposure to fine particulate matter (PM2.5) components and ozone (O3) is associated with reduced lung function. This study aimed to examine the interaction effects of PM2.5 components and O3 on lung function in young adults. A cohort study involving 1697 participants was conducted in Shandong Provin...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-09-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S014765132501187X |
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| author | Wenfeng Kang Jia Zhang Xiaoyan Wang Yun Mu Wenxiu Zheng Yajuan Zhang Mingyu Feng Zhenzhong Wang Yi Liu Xiaoshuai Zhang Peng Lu |
| author_facet | Wenfeng Kang Jia Zhang Xiaoyan Wang Yun Mu Wenxiu Zheng Yajuan Zhang Mingyu Feng Zhenzhong Wang Yi Liu Xiaoshuai Zhang Peng Lu |
| author_sort | Wenfeng Kang |
| collection | DOAJ |
| description | Exposure to fine particulate matter (PM2.5) components and ozone (O3) is associated with reduced lung function. This study aimed to examine the interaction effects of PM2.5 components and O3 on lung function in young adults. A cohort study involving 1697 participants was conducted in Shandong Province, China from September 2019 to November 2020. Pollutant data were obtained from the China High Air Pollutants (CHAP) dataset and the Tracking Air Pollution in China (TAP) dataset. Forced Vital Capacity (FVC), first-second forceful expiratory volume (FEV1.0), peak expiratory flow rate (PEF) and 50 % forceful expiratory flow rate (FEF50 %) were used as lung function indices. A linear mixed-effects model was employed to evaluate the impact of PM2.5 components and its interaction effects with O3 on lung function. Each 1 μg/m³ increase in black carbon (BC) concentration was significantly associated with 0.4027 L/s decrease in PEF (95 % confidence interval (CI): 0.2420 L/s, 0.5634 L/s). Increases in other PM2.5 components were also associated with various reduced lung function indices. Notably, the interaction term for BC and O3 was significantly associated with reduced PEF (-0.0243, 95 % CI: −0.0472, −0.0014). Synergistic effects between PM2.5 components [organic matter (OM), nitrate (NO3-)] and O3 adversely impacted lung function. A more proactive policy should be adopted to address the synergistic effects of air pollution. |
| format | Article |
| id | doaj-art-07ec13fbb3774f6097f6013ab0f04a79 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-07ec13fbb3774f6097f6013ab0f04a792025-08-20T03:41:31ZengElsevierEcotoxicology and Environmental Safety0147-65132025-09-0130311884210.1016/j.ecoenv.2025.118842Synergistic effects of PM2.5 components and ozone exposure on lung function in young adults: A cohort study in Shandong, ChinaWenfeng Kang0Jia Zhang1Xiaoyan Wang2Yun Mu3Wenxiu Zheng4Yajuan Zhang5Mingyu Feng6Zhenzhong Wang7Yi Liu8Xiaoshuai Zhang9Peng Lu10School of Public Health, Binzhou Medical University, Yantai Campus, Yantai, Shandong Province, ChinaSchool of Public Health, Binzhou Medical University, Yantai Campus, Yantai, Shandong Province, ChinaYantai Yuhuangding Hospital, Yantai, Shandong Province, ChinaSchool of Statistics and Mathematics, Shandong University of Finance and Economics, Jinan, Shandong, ChinaSchool of Public Health, Binzhou Medical University, Yantai Campus, Yantai, Shandong Province, ChinaSchool of Public Health, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, ChinaSchool of Public Health, Binzhou Medical University, Yantai Campus, Yantai, Shandong Province, ChinaSchool of Public Health, Binzhou Medical University, Yantai Campus, Yantai, Shandong Province, ChinaSchool of Public Health, Binzhou Medical University, Yantai Campus, Yantai, Shandong Province, ChinaSchool of Statistics and Mathematics, Shandong University of Finance and Economics, Jinan, Shandong, China; Corresponding author.School of Public Health, Binzhou Medical University, Yantai Campus, Yantai, Shandong Province, China; Correspondence to: School of Public Health, Binzhou Medical University, No. 346 Guanhai Road, Laishan District, Yantai, Shandong, ChinaExposure to fine particulate matter (PM2.5) components and ozone (O3) is associated with reduced lung function. This study aimed to examine the interaction effects of PM2.5 components and O3 on lung function in young adults. A cohort study involving 1697 participants was conducted in Shandong Province, China from September 2019 to November 2020. Pollutant data were obtained from the China High Air Pollutants (CHAP) dataset and the Tracking Air Pollution in China (TAP) dataset. Forced Vital Capacity (FVC), first-second forceful expiratory volume (FEV1.0), peak expiratory flow rate (PEF) and 50 % forceful expiratory flow rate (FEF50 %) were used as lung function indices. A linear mixed-effects model was employed to evaluate the impact of PM2.5 components and its interaction effects with O3 on lung function. Each 1 μg/m³ increase in black carbon (BC) concentration was significantly associated with 0.4027 L/s decrease in PEF (95 % confidence interval (CI): 0.2420 L/s, 0.5634 L/s). Increases in other PM2.5 components were also associated with various reduced lung function indices. Notably, the interaction term for BC and O3 was significantly associated with reduced PEF (-0.0243, 95 % CI: −0.0472, −0.0014). Synergistic effects between PM2.5 components [organic matter (OM), nitrate (NO3-)] and O3 adversely impacted lung function. A more proactive policy should be adopted to address the synergistic effects of air pollution.http://www.sciencedirect.com/science/article/pii/S014765132501187XPM2.5 componentsO3Synergistic effectsLung functionYoung adults |
| spellingShingle | Wenfeng Kang Jia Zhang Xiaoyan Wang Yun Mu Wenxiu Zheng Yajuan Zhang Mingyu Feng Zhenzhong Wang Yi Liu Xiaoshuai Zhang Peng Lu Synergistic effects of PM2.5 components and ozone exposure on lung function in young adults: A cohort study in Shandong, China Ecotoxicology and Environmental Safety PM2.5 components O3 Synergistic effects Lung function Young adults |
| title | Synergistic effects of PM2.5 components and ozone exposure on lung function in young adults: A cohort study in Shandong, China |
| title_full | Synergistic effects of PM2.5 components and ozone exposure on lung function in young adults: A cohort study in Shandong, China |
| title_fullStr | Synergistic effects of PM2.5 components and ozone exposure on lung function in young adults: A cohort study in Shandong, China |
| title_full_unstemmed | Synergistic effects of PM2.5 components and ozone exposure on lung function in young adults: A cohort study in Shandong, China |
| title_short | Synergistic effects of PM2.5 components and ozone exposure on lung function in young adults: A cohort study in Shandong, China |
| title_sort | synergistic effects of pm2 5 components and ozone exposure on lung function in young adults a cohort study in shandong china |
| topic | PM2.5 components O3 Synergistic effects Lung function Young adults |
| url | http://www.sciencedirect.com/science/article/pii/S014765132501187X |
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