Immune Regulation and Antitumor Effect of TIM-1
T cells play an important role in antitumor immunity, and the T cell immunoglobulin domain and the mucin domain protein-1 (TIM-1) on its surface, as a costimulatory molecule, has a strong regulatory effect on T cells. TIM-1 can regulate and enhance type 1 immune response of tumor association. Theref...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/8605134 |
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| _version_ | 1832564518810550272 |
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| author | Peng Du Ruihua Xiong Xiaodong Li Jingting Jiang |
| author_facet | Peng Du Ruihua Xiong Xiaodong Li Jingting Jiang |
| author_sort | Peng Du |
| collection | DOAJ |
| description | T cells play an important role in antitumor immunity, and the T cell immunoglobulin domain and the mucin domain protein-1 (TIM-1) on its surface, as a costimulatory molecule, has a strong regulatory effect on T cells. TIM-1 can regulate and enhance type 1 immune response of tumor association. Therefore, TIM-1 costimulatory pathways may be a promising therapeutic target in future tumor immunotherapy. This review describes the immune regulation and antitumor effect of TIM-1. |
| format | Article |
| id | doaj-art-07eab16a7561487599d784b419ff017f |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-07eab16a7561487599d784b419ff017f2025-02-03T01:10:44ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/86051348605134Immune Regulation and Antitumor Effect of TIM-1Peng Du0Ruihua Xiong1Xiaodong Li2Jingting Jiang3Department of Tumor Biological Treatment, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu 213003, ChinaDepartment of Tumor Biological Treatment, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu 213003, ChinaDepartment of Tumor Biological Treatment, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu 213003, ChinaDepartment of Tumor Biological Treatment, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu 213003, ChinaT cells play an important role in antitumor immunity, and the T cell immunoglobulin domain and the mucin domain protein-1 (TIM-1) on its surface, as a costimulatory molecule, has a strong regulatory effect on T cells. TIM-1 can regulate and enhance type 1 immune response of tumor association. Therefore, TIM-1 costimulatory pathways may be a promising therapeutic target in future tumor immunotherapy. This review describes the immune regulation and antitumor effect of TIM-1.http://dx.doi.org/10.1155/2016/8605134 |
| spellingShingle | Peng Du Ruihua Xiong Xiaodong Li Jingting Jiang Immune Regulation and Antitumor Effect of TIM-1 Journal of Immunology Research |
| title | Immune Regulation and Antitumor Effect of TIM-1 |
| title_full | Immune Regulation and Antitumor Effect of TIM-1 |
| title_fullStr | Immune Regulation and Antitumor Effect of TIM-1 |
| title_full_unstemmed | Immune Regulation and Antitumor Effect of TIM-1 |
| title_short | Immune Regulation and Antitumor Effect of TIM-1 |
| title_sort | immune regulation and antitumor effect of tim 1 |
| url | http://dx.doi.org/10.1155/2016/8605134 |
| work_keys_str_mv | AT pengdu immuneregulationandantitumoreffectoftim1 AT ruihuaxiong immuneregulationandantitumoreffectoftim1 AT xiaodongli immuneregulationandantitumoreffectoftim1 AT jingtingjiang immuneregulationandantitumoreffectoftim1 |