The biosynthesis of the cannabinoids
Abstract Cannabis has been integral to Eurasian civilization for millennia, but a century of prohibition has limited investigation. With spreading legalization, science is pivoting to study the pharmacopeia of the cannabinoids, and a thorough understanding of their biosynthesis is required to engine...
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| Format: | Article |
| Language: | English |
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BMC
2021-03-01
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| Series: | Journal of Cannabis Research |
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| Online Access: | https://doi.org/10.1186/s42238-021-00062-4 |
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| author | M. Nazir Tahir Farsheed Shahbazi Raz Simon Rondeau-Gagné John F. Trant |
| author_facet | M. Nazir Tahir Farsheed Shahbazi Raz Simon Rondeau-Gagné John F. Trant |
| author_sort | M. Nazir Tahir |
| collection | DOAJ |
| description | Abstract Cannabis has been integral to Eurasian civilization for millennia, but a century of prohibition has limited investigation. With spreading legalization, science is pivoting to study the pharmacopeia of the cannabinoids, and a thorough understanding of their biosynthesis is required to engineer strains with specific cannabinoid profiles. This review surveys the biosynthesis and biochemistry of cannabinoids. The pathways and the enzymes’ mechanisms of action are discussed as is the non-enzymatic decarboxylation of the cannabinoic acids. There are still many gaps in our knowledge about the biosynthesis of the cannabinoids, especially for the minor components, and this review highlights the tools and approaches that will be applied to generate an improved understanding and consequent access to these potentially biomedically-relevant materials. Graphical abstract |
| format | Article |
| id | doaj-art-07e837d78b7d4c77ae8e129ac8f4fab0 |
| institution | DOAJ |
| issn | 2522-5782 |
| language | English |
| publishDate | 2021-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cannabis Research |
| spelling | doaj-art-07e837d78b7d4c77ae8e129ac8f4fab02025-08-20T03:05:57ZengBMCJournal of Cannabis Research2522-57822021-03-013111210.1186/s42238-021-00062-4The biosynthesis of the cannabinoidsM. Nazir Tahir0Farsheed Shahbazi Raz1Simon Rondeau-Gagné2John F. Trant3Department of Chemistry and Biochemistry, University of WindsorDepartment of Chemistry and Biochemistry, University of WindsorDepartment of Chemistry and Biochemistry, University of WindsorDepartment of Chemistry and Biochemistry, University of WindsorAbstract Cannabis has been integral to Eurasian civilization for millennia, but a century of prohibition has limited investigation. With spreading legalization, science is pivoting to study the pharmacopeia of the cannabinoids, and a thorough understanding of their biosynthesis is required to engineer strains with specific cannabinoid profiles. This review surveys the biosynthesis and biochemistry of cannabinoids. The pathways and the enzymes’ mechanisms of action are discussed as is the non-enzymatic decarboxylation of the cannabinoic acids. There are still many gaps in our knowledge about the biosynthesis of the cannabinoids, especially for the minor components, and this review highlights the tools and approaches that will be applied to generate an improved understanding and consequent access to these potentially biomedically-relevant materials. Graphical abstracthttps://doi.org/10.1186/s42238-021-00062-4Cannabinoid biosynthesisEnzymatic transformationC. sativaDecarboxylationEnzymatic mechanism |
| spellingShingle | M. Nazir Tahir Farsheed Shahbazi Raz Simon Rondeau-Gagné John F. Trant The biosynthesis of the cannabinoids Journal of Cannabis Research Cannabinoid biosynthesis Enzymatic transformation C. sativa Decarboxylation Enzymatic mechanism |
| title | The biosynthesis of the cannabinoids |
| title_full | The biosynthesis of the cannabinoids |
| title_fullStr | The biosynthesis of the cannabinoids |
| title_full_unstemmed | The biosynthesis of the cannabinoids |
| title_short | The biosynthesis of the cannabinoids |
| title_sort | biosynthesis of the cannabinoids |
| topic | Cannabinoid biosynthesis Enzymatic transformation C. sativa Decarboxylation Enzymatic mechanism |
| url | https://doi.org/10.1186/s42238-021-00062-4 |
| work_keys_str_mv | AT mnazirtahir thebiosynthesisofthecannabinoids AT farsheedshahbaziraz thebiosynthesisofthecannabinoids AT simonrondeaugagne thebiosynthesisofthecannabinoids AT johnftrant thebiosynthesisofthecannabinoids AT mnazirtahir biosynthesisofthecannabinoids AT farsheedshahbaziraz biosynthesisofthecannabinoids AT simonrondeaugagne biosynthesisofthecannabinoids AT johnftrant biosynthesisofthecannabinoids |