Preliminary clinical study of p-iodo benzoyl moiety-modified PSMA inhibitors and prospective comparison with 68Ga-PSMA-11

Preliminary clinical study of p-iodo benzoyl moiety-modified PSMA inhibitors and prospective comparison with 68Ga-PSMA-11

Abstract Small-molecule inhibitors targeting prostate-specific membrane antigen (PSMA) have demonstrated promising results in the theranostics of prostate cancer (PCa). We designed and synthesized a novel small-molecule PSMA inhibitor, SC691. This study aimed to conduct a preliminary clinical prospe...

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Bibliographic Details
Main Authors: Jianpeng Cao, Zhanliang Sun, Zhijun Zhou, Yilin Huang, Dengsai Peng, Xue Jiang, Yue Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Prostate Cancer
Prostate-Specific membrane antigen (PSMA)
68Ga-SC691
68Ga-PSMA-11
PET/CT
Online Access:https://doi.org/10.1038/s41598-025-05344-y
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