Extracellular matrix remodeling in patients with ischemic chronic heart failure with preserved ejection fraction
Aim. To identify features, relationships between parameters of the extracellular matrix and renal function in 110 patients with ischemic chronic heart failure the activity of collagen metabolism markers (MMP-9, TIMP-1, PICP), cystatin C, structural and functional parameters of the heart were studied...
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| Format: | Article |
| Language: | English |
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Zaporizhzhia State Medical and Pharmaceutical University
2015-04-01
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| Series: | Zaporožskij Medicinskij Žurnal |
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| Online Access: | http://zmj.zsmu.edu.ua/article/view/42005/38269 |
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| _version_ | 1849305290265067520 |
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| author | V. D. Syvolap D. A. Lashkul |
| author_facet | V. D. Syvolap D. A. Lashkul |
| author_sort | V. D. Syvolap |
| collection | DOAJ |
| description | Aim. To identify features, relationships between parameters of the extracellular matrix and renal function in 110 patients with ischemic chronic heart failure the activity of collagen metabolism markers (MMP-9, TIMP-1, PICP), cystatin C, structural and functional parameters of the heart were studied using ELISA, echocardiography.
Results. It was established that imbalance in the system MMP/TIMP in ischemic heart failure with preserved left ventricular ejection fraction leads to disruption of the extracellular matrix structural functional sufficiency, increases functional failure and is associated with impaired renal function.
Conclusion. Correlation analysis showed significant relationships between MMP/TIMP and GFR, cystatin C, indicating that the significant role of extracellular matrix imbalance in the development of renal dysfunction in patients with ischemic chronic heart failure. |
| format | Article |
| id | doaj-art-07dda2087ea04ee7b6a98040ee22fb30 |
| institution | Kabale University |
| issn | 2306-4145 2310-1210 |
| language | English |
| publishDate | 2015-04-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj-art-07dda2087ea04ee7b6a98040ee22fb302025-08-20T03:55:28ZengZaporizhzhia State Medical and Pharmaceutical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102015-04-0121014http://dx.doi.org/10.14739/2310-1210.2015.2.42005Extracellular matrix remodeling in patients with ischemic chronic heart failure with preserved ejection fractionV. D. SyvolapD. A. LashkulAim. To identify features, relationships between parameters of the extracellular matrix and renal function in 110 patients with ischemic chronic heart failure the activity of collagen metabolism markers (MMP-9, TIMP-1, PICP), cystatin C, structural and functional parameters of the heart were studied using ELISA, echocardiography. Results. It was established that imbalance in the system MMP/TIMP in ischemic heart failure with preserved left ventricular ejection fraction leads to disruption of the extracellular matrix structural functional sufficiency, increases functional failure and is associated with impaired renal function. Conclusion. Correlation analysis showed significant relationships between MMP/TIMP and GFR, cystatin C, indicating that the significant role of extracellular matrix imbalance in the development of renal dysfunction in patients with ischemic chronic heart failure.http://zmj.zsmu.edu.ua/article/view/42005/38269Heart FailureBiomarkersFibrosis |
| spellingShingle | V. D. Syvolap D. A. Lashkul Extracellular matrix remodeling in patients with ischemic chronic heart failure with preserved ejection fraction Zaporožskij Medicinskij Žurnal Heart Failure Biomarkers Fibrosis |
| title | Extracellular matrix remodeling in patients with ischemic chronic heart failure with preserved ejection fraction |
| title_full | Extracellular matrix remodeling in patients with ischemic chronic heart failure with preserved ejection fraction |
| title_fullStr | Extracellular matrix remodeling in patients with ischemic chronic heart failure with preserved ejection fraction |
| title_full_unstemmed | Extracellular matrix remodeling in patients with ischemic chronic heart failure with preserved ejection fraction |
| title_short | Extracellular matrix remodeling in patients with ischemic chronic heart failure with preserved ejection fraction |
| title_sort | extracellular matrix remodeling in patients with ischemic chronic heart failure with preserved ejection fraction |
| topic | Heart Failure Biomarkers Fibrosis |
| url | http://zmj.zsmu.edu.ua/article/view/42005/38269 |
| work_keys_str_mv | AT vdsyvolap extracellularmatrixremodelinginpatientswithischemicchronicheartfailurewithpreservedejectionfraction AT dalashkul extracellularmatrixremodelinginpatientswithischemicchronicheartfailurewithpreservedejectionfraction |