Natural Products for Melanoma Therapy: From Traditional Medicine to Modern Drug Discovery
Melanoma, a type of skin cancer originating from melanocytes, represents a significant public health concern according to the World Health Organization. It is one of the most commonly diagnosed cancers worldwide, particularly affecting populations in Europe and North America, with an increasing inci...
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| Format: | Article |
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MDPI AG
2025-03-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/14/6/951 |
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| author | Soojin An Jeongeun An Dain Lee Han Na Kang Sojin Kang Chi-Hoon Ahn Rony Abdi Syahputra Rosy Iara Maciel A. Ribeiro Bonglee Kim |
| author_facet | Soojin An Jeongeun An Dain Lee Han Na Kang Sojin Kang Chi-Hoon Ahn Rony Abdi Syahputra Rosy Iara Maciel A. Ribeiro Bonglee Kim |
| author_sort | Soojin An |
| collection | DOAJ |
| description | Melanoma, a type of skin cancer originating from melanocytes, represents a significant public health concern according to the World Health Organization. It is one of the most commonly diagnosed cancers worldwide, particularly affecting populations in Europe and North America, with an increasing incidence in Asia. The rise emphasizes the need for diversified treatment approaches. Conventional treatments for melanoma, including immunotherapy, chemotherapy, and targeted therapies like the FDA-approved Opdivo and Relatlimab, often come with severe side effects and high relapse rates. Consequently, natural products have gained considerable attention for their potential to enhance therapeutic outcomes and reduce adverse effects. This systematic review evaluates the anti-cancer properties of natural products against melanoma, examining 52 studies from PubMed and Google Scholar. Our analysis focuses on the antioxidant, anti-angiogenesis, anti-metastatic, and apoptosis-inducing activities of these compounds, also discussing the regulatory factors involved. The findings advocate for intensified research into natural products as complementary agents in melanoma treatment, aiming to improve efficacy and patient quality of life. Further in vitro, in vivo, and clinical trials are essential to validate their effectiveness and integrate them into standard care protocols. |
| format | Article |
| id | doaj-art-07d72eca56284eb39bca16ea2adb1166 |
| institution | OA Journals |
| issn | 2223-7747 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj-art-07d72eca56284eb39bca16ea2adb11662025-08-20T01:48:54ZengMDPI AGPlants2223-77472025-03-0114695110.3390/plants14060951Natural Products for Melanoma Therapy: From Traditional Medicine to Modern Drug DiscoverySoojin An0Jeongeun An1Dain Lee2Han Na Kang3Sojin Kang4Chi-Hoon Ahn5Rony Abdi Syahputra6Rosy Iara Maciel A. Ribeiro7Bonglee Kim8College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of KoreaCollege of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of KoreaCollege of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of KoreaKM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of KoreaCollege of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of KoreaCollege of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of KoreaDepartment of Biological Sciences, State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga), Yogyakarta 55281, IndonesiaLaboratory of Experimental Pathology, Federal University of São João del Rei-CCO/UFSJ, Divinópolis 35501-296, BrazilCollege of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of KoreaMelanoma, a type of skin cancer originating from melanocytes, represents a significant public health concern according to the World Health Organization. It is one of the most commonly diagnosed cancers worldwide, particularly affecting populations in Europe and North America, with an increasing incidence in Asia. The rise emphasizes the need for diversified treatment approaches. Conventional treatments for melanoma, including immunotherapy, chemotherapy, and targeted therapies like the FDA-approved Opdivo and Relatlimab, often come with severe side effects and high relapse rates. Consequently, natural products have gained considerable attention for their potential to enhance therapeutic outcomes and reduce adverse effects. This systematic review evaluates the anti-cancer properties of natural products against melanoma, examining 52 studies from PubMed and Google Scholar. Our analysis focuses on the antioxidant, anti-angiogenesis, anti-metastatic, and apoptosis-inducing activities of these compounds, also discussing the regulatory factors involved. The findings advocate for intensified research into natural products as complementary agents in melanoma treatment, aiming to improve efficacy and patient quality of life. Further in vitro, in vivo, and clinical trials are essential to validate their effectiveness and integrate them into standard care protocols.https://www.mdpi.com/2223-7747/14/6/951melanomanatural productsantioxidantanti-cancerapoptosisreactive oxygen species (ROS) |
| spellingShingle | Soojin An Jeongeun An Dain Lee Han Na Kang Sojin Kang Chi-Hoon Ahn Rony Abdi Syahputra Rosy Iara Maciel A. Ribeiro Bonglee Kim Natural Products for Melanoma Therapy: From Traditional Medicine to Modern Drug Discovery Plants melanoma natural products antioxidant anti-cancer apoptosis reactive oxygen species (ROS) |
| title | Natural Products for Melanoma Therapy: From Traditional Medicine to Modern Drug Discovery |
| title_full | Natural Products for Melanoma Therapy: From Traditional Medicine to Modern Drug Discovery |
| title_fullStr | Natural Products for Melanoma Therapy: From Traditional Medicine to Modern Drug Discovery |
| title_full_unstemmed | Natural Products for Melanoma Therapy: From Traditional Medicine to Modern Drug Discovery |
| title_short | Natural Products for Melanoma Therapy: From Traditional Medicine to Modern Drug Discovery |
| title_sort | natural products for melanoma therapy from traditional medicine to modern drug discovery |
| topic | melanoma natural products antioxidant anti-cancer apoptosis reactive oxygen species (ROS) |
| url | https://www.mdpi.com/2223-7747/14/6/951 |
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