Efficacy of ALA-PDT for epidermoid cyst on the face: A retrospective study
Background: Epidermoid cysts are usually single, benign, keratin-filled cysts which occur mainly on the face and upper trunk of young adults. Surgical resection is the main treatment, which inevitably leaves scars and may recur. Photodynamic therapy (PDT) has been reported as a non-invasive and prom...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-08-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100025001735 |
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| author | Haiyan Zhang Yu Yan Yan Zhao Zhongxia Zhou Jiawen Gao Ronald Sroka Linglin Zhang Xiuli Wang |
| author_facet | Haiyan Zhang Yu Yan Yan Zhao Zhongxia Zhou Jiawen Gao Ronald Sroka Linglin Zhang Xiuli Wang |
| author_sort | Haiyan Zhang |
| collection | DOAJ |
| description | Background: Epidermoid cysts are usually single, benign, keratin-filled cysts which occur mainly on the face and upper trunk of young adults. Surgical resection is the main treatment, which inevitably leaves scars and may recur. Photodynamic therapy (PDT) has been reported as a non-invasive and promising treatment for various skin diseases with cosmetic benefits.Methods: 14 patients with single epidermoid cyst located on the face received ALA-PDT treatment. After the plum-blossom needle pretreatment, cyst was incubated with 5 % ALA cream for 30 min and then irradiated with 633 nm LED red light. If complete remission wasn’t achieved after one session of ALA-PDT treatment, more sessions would be repeated once every 1–2 weeks. Follow-ups were conducted every 2 weeks after the end of treatment.Results: All patients achieved complete regression of cyst after 1 to 3 ALA-PDT sessions. None of the patients experienced recurrence or scarring during the follow-up period (0.5 to 28months). Mild adverse effects were observed, including transient pain, erythema, and edema.Conclusion: In this observational study, ALA-PDT showed good efficacy and mild adverse reactions, suggesting that ALA-PDT is a promising treatment for epidermoid cysts on the face with cosmetic benefits. |
| format | Article |
| id | doaj-art-07d08ae980944a14b00522e89389042a |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-07d08ae980944a14b00522e89389042a2025-08-20T04:00:40ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-08-015410464110.1016/j.pdpdt.2025.104641Efficacy of ALA-PDT for epidermoid cyst on the face: A retrospective studyHaiyan Zhang0Yu Yan1Yan Zhao2Zhongxia Zhou3Jiawen Gao4Ronald Sroka5Linglin Zhang6Xiuli Wang7Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, 200043, ChinaInstitute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, 200043, ChinaInstitute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, 200043, ChinaInstitute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, 200043, ChinaInstitute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, 200043, ChinaLaser-Forschungslabor, LIFE Center, LMU University Hospital, LMU Munich, 82152 Planegg, Germany; Department of Urology, LMU University Hospital, LMU Munich, 81377 Munich, GermanyInstitute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, 200043, China; Corresponding authors.Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, 200043, China; Corresponding authors.Background: Epidermoid cysts are usually single, benign, keratin-filled cysts which occur mainly on the face and upper trunk of young adults. Surgical resection is the main treatment, which inevitably leaves scars and may recur. Photodynamic therapy (PDT) has been reported as a non-invasive and promising treatment for various skin diseases with cosmetic benefits.Methods: 14 patients with single epidermoid cyst located on the face received ALA-PDT treatment. After the plum-blossom needle pretreatment, cyst was incubated with 5 % ALA cream for 30 min and then irradiated with 633 nm LED red light. If complete remission wasn’t achieved after one session of ALA-PDT treatment, more sessions would be repeated once every 1–2 weeks. Follow-ups were conducted every 2 weeks after the end of treatment.Results: All patients achieved complete regression of cyst after 1 to 3 ALA-PDT sessions. None of the patients experienced recurrence or scarring during the follow-up period (0.5 to 28months). Mild adverse effects were observed, including transient pain, erythema, and edema.Conclusion: In this observational study, ALA-PDT showed good efficacy and mild adverse reactions, suggesting that ALA-PDT is a promising treatment for epidermoid cysts on the face with cosmetic benefits.http://www.sciencedirect.com/science/article/pii/S15721000250017355-aminolevulinic acid (ALA)Photodynamic therapy (PDT)Epidermoid cysts |
| spellingShingle | Haiyan Zhang Yu Yan Yan Zhao Zhongxia Zhou Jiawen Gao Ronald Sroka Linglin Zhang Xiuli Wang Efficacy of ALA-PDT for epidermoid cyst on the face: A retrospective study Photodiagnosis and Photodynamic Therapy 5-aminolevulinic acid (ALA) Photodynamic therapy (PDT) Epidermoid cysts |
| title | Efficacy of ALA-PDT for epidermoid cyst on the face: A retrospective study |
| title_full | Efficacy of ALA-PDT for epidermoid cyst on the face: A retrospective study |
| title_fullStr | Efficacy of ALA-PDT for epidermoid cyst on the face: A retrospective study |
| title_full_unstemmed | Efficacy of ALA-PDT for epidermoid cyst on the face: A retrospective study |
| title_short | Efficacy of ALA-PDT for epidermoid cyst on the face: A retrospective study |
| title_sort | efficacy of ala pdt for epidermoid cyst on the face a retrospective study |
| topic | 5-aminolevulinic acid (ALA) Photodynamic therapy (PDT) Epidermoid cysts |
| url | http://www.sciencedirect.com/science/article/pii/S1572100025001735 |
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