Case report: Gouty renal abscess and gouty sacroiliitis associated with genetic variants of a young woman
Gout is a form of inflammatory arthritis characterized by the deposition of monosodium urate (MSU) crystals in the joints, resulting from a disorder in purine metabolism. It occurs more frequently in men than in women prior to menopause and is rare in young women. Gout can lead to various health com...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1509018/full |
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| author | Dabin Tang Dabin Tang Yubao Jiang Yubao Jiang Guichen Ling Guichen Ling Jianyong Zhang Jianyong Zhang Jingjing Xie Jingjing Xie |
| author_facet | Dabin Tang Dabin Tang Yubao Jiang Yubao Jiang Guichen Ling Guichen Ling Jianyong Zhang Jianyong Zhang Jingjing Xie Jingjing Xie |
| author_sort | Dabin Tang |
| collection | DOAJ |
| description | Gout is a form of inflammatory arthritis characterized by the deposition of monosodium urate (MSU) crystals in the joints, resulting from a disorder in purine metabolism. It occurs more frequently in men than in women prior to menopause and is rare in young women. Gout can lead to various health complications, with many patients experiencing a significant burden of chronic kidney disease (CKD) and joint deformities. The development of gout is influenced by a complex interplay of genetic, environmental, and lifestyle factors, with elevated serum MSU levels serving as a key risk factor for its onset. However, only 10% of individuals with hyperuricemia go on to develop clinical gout, and several susceptibility loci are associated with the condition. Here, we present a case of a young woman with gouty sacroiliitis and gouty nephropathy linked to susceptibility loci. |
| format | Article |
| id | doaj-art-07cdb065629644f7bf4f7d46855d7ab6 |
| institution | DOAJ |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-07cdb065629644f7bf4f7d46855d7ab62025-08-20T02:45:52ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-02-011210.3389/fmed.2025.15090181509018Case report: Gouty renal abscess and gouty sacroiliitis associated with genetic variants of a young womanDabin Tang0Dabin Tang1Yubao Jiang2Yubao Jiang3Guichen Ling4Guichen Ling5Jianyong Zhang6Jianyong Zhang7Jingjing Xie8Jingjing Xie9The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, ChinaThe Department of Rheumatology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, Guangdong, ChinaThe Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, ChinaThe Department of Rheumatology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, Guangdong, ChinaThe Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, ChinaThe Department of Rheumatology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, Guangdong, ChinaThe Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, ChinaThe Department of Rheumatology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, Guangdong, ChinaThe Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, ChinaThe Department of Rheumatology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, Guangdong, ChinaGout is a form of inflammatory arthritis characterized by the deposition of monosodium urate (MSU) crystals in the joints, resulting from a disorder in purine metabolism. It occurs more frequently in men than in women prior to menopause and is rare in young women. Gout can lead to various health complications, with many patients experiencing a significant burden of chronic kidney disease (CKD) and joint deformities. The development of gout is influenced by a complex interplay of genetic, environmental, and lifestyle factors, with elevated serum MSU levels serving as a key risk factor for its onset. However, only 10% of individuals with hyperuricemia go on to develop clinical gout, and several susceptibility loci are associated with the condition. Here, we present a case of a young woman with gouty sacroiliitis and gouty nephropathy linked to susceptibility loci.https://www.frontiersin.org/articles/10.3389/fmed.2025.1509018/fullgoutrenal abscesssacroiliitisgenetic variantsyoung woman |
| spellingShingle | Dabin Tang Dabin Tang Yubao Jiang Yubao Jiang Guichen Ling Guichen Ling Jianyong Zhang Jianyong Zhang Jingjing Xie Jingjing Xie Case report: Gouty renal abscess and gouty sacroiliitis associated with genetic variants of a young woman Frontiers in Medicine gout renal abscess sacroiliitis genetic variants young woman |
| title | Case report: Gouty renal abscess and gouty sacroiliitis associated with genetic variants of a young woman |
| title_full | Case report: Gouty renal abscess and gouty sacroiliitis associated with genetic variants of a young woman |
| title_fullStr | Case report: Gouty renal abscess and gouty sacroiliitis associated with genetic variants of a young woman |
| title_full_unstemmed | Case report: Gouty renal abscess and gouty sacroiliitis associated with genetic variants of a young woman |
| title_short | Case report: Gouty renal abscess and gouty sacroiliitis associated with genetic variants of a young woman |
| title_sort | case report gouty renal abscess and gouty sacroiliitis associated with genetic variants of a young woman |
| topic | gout renal abscess sacroiliitis genetic variants young woman |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1509018/full |
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