AAV9-cBIN1 gene therapy rescues chronic heart failure due to ischemic cardiomyopathy in a canine model

AAV9-cBIN1 gene therapy rescues chronic heart failure due to ischemic cardiomyopathy in a canine model

Abstract Background Ischemic cardiomyopathy and resultant heart failure (HF) is a significant cause of morbidity and mortality worldwide. Downregulation of cardiac bridging integrator 1 (cBIN1), a membrane scaffolding protein responsible for organizing t-tubules and organizing the calcium handing ap...

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Main Authors: Muhammad S. Khan, Douglas Smego, Jing Li, Yuki Ishidoya, Emmanuel Offei, Martha Sofia Ruiz Castillo, Annie M. Hirahara, Pia Balmaceda, Jennifer Hunter, Anand Athavale, Monica P. Revelo, Joseph A. Palatinus, Craig H. Selzman, Ravi Ranjan, TingTing Hong, Derek J. Dosdall, Robin M. Shaw
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Communications Medicine
Online Access:https://doi.org/10.1038/s43856-025-00787-w
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