Exploration of the Dual Role of Dectin-1 in Tumor Development and Its Therapeutic Potential
Immunotherapy, particularly immune checkpoint inhibitors like PD-1, PD-L1, and CTLA-4, has revolutionized cancer treatment. However, the role of the innate immune system, especially pattern recognition receptors, in cancer development and immunity is gaining more and more attention. Dectin-1, a C-ty...
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MDPI AG
2024-11-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/31/11/536 |
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| author | Yuxuan Cai Ke Wu |
| author_facet | Yuxuan Cai Ke Wu |
| author_sort | Yuxuan Cai |
| collection | DOAJ |
| description | Immunotherapy, particularly immune checkpoint inhibitors like PD-1, PD-L1, and CTLA-4, has revolutionized cancer treatment. However, the role of the innate immune system, especially pattern recognition receptors, in cancer development and immunity is gaining more and more attention. Dectin-1, a C-type lectin receptor primarily involved in antifungal immunity, has emerged as a significant player in cancer biology, exhibiting both pro-tumor and anti-tumor roles. This dual function largely depends on the tumor type and microenvironment. Dectin-1 can promote immune responses against tumors like melanoma and breast cancer by enhancing both innate and adaptive immunity. However, in tumors like pancreatic ductal adenocarcinoma and colorectal cancer, Dectin-1 activation suppresses T cell immunity, facilitating tumor progression. This review explores the complex mechanisms by which Dectin-1 modulates the tumor microenvironment and discusses its potential as a therapeutic target for cancer treatment. |
| format | Article |
| id | doaj-art-07ca66ae0ac448a9b3f795bacc1244a7 |
| institution | OA Journals |
| issn | 1198-0052 1718-7729 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj-art-07ca66ae0ac448a9b3f795bacc1244a72025-08-20T02:28:04ZengMDPI AGCurrent Oncology1198-00521718-77292024-11-0131117275728610.3390/curroncol31110536Exploration of the Dual Role of Dectin-1 in Tumor Development and Its Therapeutic PotentialYuxuan Cai0Ke Wu1Department of Gastrointestinal Surgery, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Gastrointestinal Surgery, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan 430022, ChinaImmunotherapy, particularly immune checkpoint inhibitors like PD-1, PD-L1, and CTLA-4, has revolutionized cancer treatment. However, the role of the innate immune system, especially pattern recognition receptors, in cancer development and immunity is gaining more and more attention. Dectin-1, a C-type lectin receptor primarily involved in antifungal immunity, has emerged as a significant player in cancer biology, exhibiting both pro-tumor and anti-tumor roles. This dual function largely depends on the tumor type and microenvironment. Dectin-1 can promote immune responses against tumors like melanoma and breast cancer by enhancing both innate and adaptive immunity. However, in tumors like pancreatic ductal adenocarcinoma and colorectal cancer, Dectin-1 activation suppresses T cell immunity, facilitating tumor progression. This review explores the complex mechanisms by which Dectin-1 modulates the tumor microenvironment and discusses its potential as a therapeutic target for cancer treatment.https://www.mdpi.com/1718-7729/31/11/536Dectin-1tumor immunologytumor microenvironmenttargeted therapypattern recognition receptor |
| spellingShingle | Yuxuan Cai Ke Wu Exploration of the Dual Role of Dectin-1 in Tumor Development and Its Therapeutic Potential Current Oncology Dectin-1 tumor immunology tumor microenvironment targeted therapy pattern recognition receptor |
| title | Exploration of the Dual Role of Dectin-1 in Tumor Development and Its Therapeutic Potential |
| title_full | Exploration of the Dual Role of Dectin-1 in Tumor Development and Its Therapeutic Potential |
| title_fullStr | Exploration of the Dual Role of Dectin-1 in Tumor Development and Its Therapeutic Potential |
| title_full_unstemmed | Exploration of the Dual Role of Dectin-1 in Tumor Development and Its Therapeutic Potential |
| title_short | Exploration of the Dual Role of Dectin-1 in Tumor Development and Its Therapeutic Potential |
| title_sort | exploration of the dual role of dectin 1 in tumor development and its therapeutic potential |
| topic | Dectin-1 tumor immunology tumor microenvironment targeted therapy pattern recognition receptor |
| url | https://www.mdpi.com/1718-7729/31/11/536 |
| work_keys_str_mv | AT yuxuancai explorationofthedualroleofdectin1intumordevelopmentanditstherapeuticpotential AT kewu explorationofthedualroleofdectin1intumordevelopmentanditstherapeuticpotential |