Dopamine Genetics: Substance Use Disorders vs. Parkinson’s Disease
It is established that Substance use disorders (SUDs) and Parkinson’s Disease (PD) among many other neuropsychiatric disorders are dopamine (DA)-related brain disorders with strong heritability. However, it is unclear whether DA-associated genetic risks share commonality across these disorders. This...
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| Format: | Article |
| Language: | Russian |
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Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation
2019-12-01
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| Series: | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
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| Online Access: | https://www.bekhterevreview.com/jour/article/view/298 |
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| author | Z. Carl Lin F. S. Hall R. L. Bell |
| author_facet | Z. Carl Lin F. S. Hall R. L. Bell |
| author_sort | Z. Carl Lin |
| collection | DOAJ |
| description | It is established that Substance use disorders (SUDs) and Parkinson’s Disease (PD) among many other neuropsychiatric disorders are dopamine (DA)-related brain disorders with strong heritability. However, it is unclear whether DA-associated genetic risks share commonality across these disorders. This study utilizes the Genotype and Phenotype Database (dbGaP), by downloading related genome-wide association studies (GWAS) for individual genotype/phenotypes. According to our results DA pathways are significantly implicated in the genetic etiology of both SUDs and PD but much more in the former. Epistatic effects may represent a major portion of missing heritability observed in current main effect-oriented GWAS analyses. |
| format | Article |
| id | doaj-art-07ca286a49e4415493ceabf5c412897c |
| institution | DOAJ |
| issn | 2313-7053 2713-055X |
| language | Russian |
| publishDate | 2019-12-01 |
| publisher | Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation |
| record_format | Article |
| series | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
| spelling | doaj-art-07ca286a49e4415493ceabf5c412897c2025-08-20T03:20:23ZrusFederal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian FederationОбозрение психиатрии и медицинской психологии имени В.М. Бехтерева2313-70532713-055X2019-12-0104-1363810.31363/2313-7053-2019-4-1-36-38277Dopamine Genetics: Substance Use Disorders vs. Parkinson’s DiseaseZ. Carl Lin0F. S. Hall1R. L. Bell2Laboratory of Psychiatric Neurogenomics at McLean Hospital, and Department of Psychiatry, Harvard Medical SchoolDepartment of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of ToledoDepartment of Psychiatry, Institute of Psychiatric Research, Indiana University School of MedicineIt is established that Substance use disorders (SUDs) and Parkinson’s Disease (PD) among many other neuropsychiatric disorders are dopamine (DA)-related brain disorders with strong heritability. However, it is unclear whether DA-associated genetic risks share commonality across these disorders. This study utilizes the Genotype and Phenotype Database (dbGaP), by downloading related genome-wide association studies (GWAS) for individual genotype/phenotypes. According to our results DA pathways are significantly implicated in the genetic etiology of both SUDs and PD but much more in the former. Epistatic effects may represent a major portion of missing heritability observed in current main effect-oriented GWAS analyses.https://www.bekhterevreview.com/jour/article/view/298disease-specificepistasisgenetic etiologymissing heritabilityneuropsychiatric disorderspathways |
| spellingShingle | Z. Carl Lin F. S. Hall R. L. Bell Dopamine Genetics: Substance Use Disorders vs. Parkinson’s Disease Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева disease-specific epistasis genetic etiology missing heritability neuropsychiatric disorders pathways |
| title | Dopamine Genetics: Substance Use Disorders vs. Parkinson’s Disease |
| title_full | Dopamine Genetics: Substance Use Disorders vs. Parkinson’s Disease |
| title_fullStr | Dopamine Genetics: Substance Use Disorders vs. Parkinson’s Disease |
| title_full_unstemmed | Dopamine Genetics: Substance Use Disorders vs. Parkinson’s Disease |
| title_short | Dopamine Genetics: Substance Use Disorders vs. Parkinson’s Disease |
| title_sort | dopamine genetics substance use disorders vs parkinson s disease |
| topic | disease-specific epistasis genetic etiology missing heritability neuropsychiatric disorders pathways |
| url | https://www.bekhterevreview.com/jour/article/view/298 |
| work_keys_str_mv | AT zcarllin dopaminegeneticssubstanceusedisordersvsparkinsonsdisease AT fshall dopaminegeneticssubstanceusedisordersvsparkinsonsdisease AT rlbell dopaminegeneticssubstanceusedisordersvsparkinsonsdisease |