Relationship between radiation dose and cerebral microbleed formation in dogs with intracranial tumors
Abstract Background Cerebral microbleeds (CMBs) are a possible sequela in human brain tumor patients treated with radiation therapy (RT). No such association is reported in dogs. Objectives To investigate whether CMBs occur in dogs after radiotherapy, and if there is an association between number an...
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| Format: | Article |
| Language: | English |
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Wiley
2024-11-01
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| Series: | Journal of Veterinary Internal Medicine |
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| Online Access: | https://doi.org/10.1111/jvim.17213 |
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| author | Chris Staudinger Matthias Dennler Maximilian Körner Katrin Beckmann Malwina E. Kowalska Valeria Meier Carla Rohrer Bley |
| author_facet | Chris Staudinger Matthias Dennler Maximilian Körner Katrin Beckmann Malwina E. Kowalska Valeria Meier Carla Rohrer Bley |
| author_sort | Chris Staudinger |
| collection | DOAJ |
| description | Abstract Background Cerebral microbleeds (CMBs) are a possible sequela in human brain tumor patients treated with radiation therapy (RT). No such association is reported in dogs. Objectives To investigate whether CMBs occur in dogs after radiotherapy, and if there is an association between number and dose, and an increase over time. Animals Thirty‐four client‐owned dogs irradiated for primary intracranial neoplasia. ≥2 magnetic resonance imaging (MRI) scans including susceptibility‐weighted imaging (SWI) were required. Methods Retrospective, observational, single‐center study. Cerebral microbleeds identified on 3 T SWI were counted within the entire brain, and within low‐ (<20 Gy), intermediate‐ (20‐30 Gy), and high‐ (>30 Gy) dose regions. A generalized linear mixed‐effects model was used to analyze the relationship between the CMBs count and the predictor variables (irradiation dose, time after treatment). Results Median follow‐up time was 12.6 months (range, 1.8‐37.6 months). Eighty‐three MR scans were performed. In 4/15 dogs (27%, 95% CI, 10%‐52%) CMBs were present at baseline. ≥1 CMBs after RT were identified in 21/34 dogs (62%, 95% CI, 45%‐77%). With each month, the number of CMBs increased by 14% (95% CI, 11%‐16%; P < .001). The odds of developing CMBs in the high‐dose region are 4.7 times (95% CI, 3.9‐5.6; P < .001) greater compared with the low‐dose region. Conclusion and Clinical Importance RT is 1 possible cause of CMBs formation in dogs. Cerebral microbleeds are most likely to occur in the peritumoral high‐dose volume, to be chronic, and to increase in number over time. Their clinical relevance remains unknown. |
| format | Article |
| id | doaj-art-07c6c757654e4953bc619cd91ca42503 |
| institution | OA Journals |
| issn | 0891-6640 1939-1676 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj-art-07c6c757654e4953bc619cd91ca425032025-08-20T02:33:01ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762024-11-013863182319210.1111/jvim.17213Relationship between radiation dose and cerebral microbleed formation in dogs with intracranial tumorsChris Staudinger0Matthias Dennler1Maximilian Körner2Katrin Beckmann3Malwina E. Kowalska4Valeria Meier5Carla Rohrer Bley6Clinic for Diagnostic Imaging, Department of Clinical Diagnostics and Services, Vetsuisse Faculty University of Zurich Zurich SwitzerlandClinic for Diagnostic Imaging, Department of Clinical Diagnostics and Services, Vetsuisse Faculty University of Zurich Zurich SwitzerlandDivision of Radiation Oncology, Department for Small Animals, Vetsuisse Faculty University of Zurich Zurich SwitzerlandDivision of Neurology, Department for Small Animals, Vetsuisse Faculty University of Zurich Zurich SwitzerlandSection of Epidemiology, Vetsuisse Faculty University of Zurich Zurich SwitzerlandDivision of Radiation Oncology, Department for Small Animals, Vetsuisse Faculty University of Zurich Zurich SwitzerlandDivision of Radiation Oncology, Department for Small Animals, Vetsuisse Faculty University of Zurich Zurich SwitzerlandAbstract Background Cerebral microbleeds (CMBs) are a possible sequela in human brain tumor patients treated with radiation therapy (RT). No such association is reported in dogs. Objectives To investigate whether CMBs occur in dogs after radiotherapy, and if there is an association between number and dose, and an increase over time. Animals Thirty‐four client‐owned dogs irradiated for primary intracranial neoplasia. ≥2 magnetic resonance imaging (MRI) scans including susceptibility‐weighted imaging (SWI) were required. Methods Retrospective, observational, single‐center study. Cerebral microbleeds identified on 3 T SWI were counted within the entire brain, and within low‐ (<20 Gy), intermediate‐ (20‐30 Gy), and high‐ (>30 Gy) dose regions. A generalized linear mixed‐effects model was used to analyze the relationship between the CMBs count and the predictor variables (irradiation dose, time after treatment). Results Median follow‐up time was 12.6 months (range, 1.8‐37.6 months). Eighty‐three MR scans were performed. In 4/15 dogs (27%, 95% CI, 10%‐52%) CMBs were present at baseline. ≥1 CMBs after RT were identified in 21/34 dogs (62%, 95% CI, 45%‐77%). With each month, the number of CMBs increased by 14% (95% CI, 11%‐16%; P < .001). The odds of developing CMBs in the high‐dose region are 4.7 times (95% CI, 3.9‐5.6; P < .001) greater compared with the low‐dose region. Conclusion and Clinical Importance RT is 1 possible cause of CMBs formation in dogs. Cerebral microbleeds are most likely to occur in the peritumoral high‐dose volume, to be chronic, and to increase in number over time. Their clinical relevance remains unknown.https://doi.org/10.1111/jvim.17213brain tumorcerebrovascularlate radiation toxicityradiation therapyradiation‐induced |
| spellingShingle | Chris Staudinger Matthias Dennler Maximilian Körner Katrin Beckmann Malwina E. Kowalska Valeria Meier Carla Rohrer Bley Relationship between radiation dose and cerebral microbleed formation in dogs with intracranial tumors Journal of Veterinary Internal Medicine brain tumor cerebrovascular late radiation toxicity radiation therapy radiation‐induced |
| title | Relationship between radiation dose and cerebral microbleed formation in dogs with intracranial tumors |
| title_full | Relationship between radiation dose and cerebral microbleed formation in dogs with intracranial tumors |
| title_fullStr | Relationship between radiation dose and cerebral microbleed formation in dogs with intracranial tumors |
| title_full_unstemmed | Relationship between radiation dose and cerebral microbleed formation in dogs with intracranial tumors |
| title_short | Relationship between radiation dose and cerebral microbleed formation in dogs with intracranial tumors |
| title_sort | relationship between radiation dose and cerebral microbleed formation in dogs with intracranial tumors |
| topic | brain tumor cerebrovascular late radiation toxicity radiation therapy radiation‐induced |
| url | https://doi.org/10.1111/jvim.17213 |
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