Mediastinal cryptococcoma as part of disseminated cryptococcosis in HIV-negative pregnant woman with Myasthenia Gravis: Autopsy case report

Cryptococcosis is a fungal infection commonly found in immunocompromised individuals, but it can also affect immunocompetent individuals. A pregnant woman with myasthenia gravis, HIV-negative, died after a diagnosis of tuberculosis. An autopsy revealed a mediastinal mass and organ involvement, indic...

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Main Authors: Bianca Ponnamma Samy, Nosipho Maria Thobakgale, Moshawa Calvin Khaba
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Medical Mycology Case Reports
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Online Access:http://www.sciencedirect.com/science/article/pii/S2211753925000351
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author Bianca Ponnamma Samy
Nosipho Maria Thobakgale
Moshawa Calvin Khaba
author_facet Bianca Ponnamma Samy
Nosipho Maria Thobakgale
Moshawa Calvin Khaba
author_sort Bianca Ponnamma Samy
collection DOAJ
description Cryptococcosis is a fungal infection commonly found in immunocompromised individuals, but it can also affect immunocompetent individuals. A pregnant woman with myasthenia gravis, HIV-negative, died after a diagnosis of tuberculosis. An autopsy revealed a mediastinal mass and organ involvement, indicating a disseminated cryptococcal infection. This case highlights the importance of maintaining a high index of suspicion for cryptococcal infection in immunosuppressed individuals, even without HIV/AIDS. Early detection is achieved by measuring serum cryptococcal antigen.
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institution Kabale University
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publishDate 2025-09-01
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series Medical Mycology Case Reports
spelling doaj-art-07c1af7384794d62b98c5d01a4063e9c2025-08-24T05:12:10ZengElsevierMedical Mycology Case Reports2211-75392025-09-014910072610.1016/j.mmcr.2025.100726Mediastinal cryptococcoma as part of disseminated cryptococcosis in HIV-negative pregnant woman with Myasthenia Gravis: Autopsy case reportBianca Ponnamma Samy0Nosipho Maria Thobakgale1Moshawa Calvin Khaba2Department of Anatomical Pathology, Dr George Mukhari Academic Laboratory, National Health Laboratory Service, Sefako Makgatho Health Sciences University, South AfricaDepartment of Anatomical Pathology, Dr George Mukhari Academic Laboratory, National Health Laboratory Service, Sefako Makgatho Health Sciences University, South AfricaCorresponding author.; Department of Anatomical Pathology, Dr George Mukhari Academic Laboratory, National Health Laboratory Service, Sefako Makgatho Health Sciences University, South AfricaCryptococcosis is a fungal infection commonly found in immunocompromised individuals, but it can also affect immunocompetent individuals. A pregnant woman with myasthenia gravis, HIV-negative, died after a diagnosis of tuberculosis. An autopsy revealed a mediastinal mass and organ involvement, indicating a disseminated cryptococcal infection. This case highlights the importance of maintaining a high index of suspicion for cryptococcal infection in immunosuppressed individuals, even without HIV/AIDS. Early detection is achieved by measuring serum cryptococcal antigen.http://www.sciencedirect.com/science/article/pii/S2211753925000351Myasthenia gravisCryptococcosisPregnancyHIV/AIDSAutopsy
spellingShingle Bianca Ponnamma Samy
Nosipho Maria Thobakgale
Moshawa Calvin Khaba
Mediastinal cryptococcoma as part of disseminated cryptococcosis in HIV-negative pregnant woman with Myasthenia Gravis: Autopsy case report
Medical Mycology Case Reports
Myasthenia gravis
Cryptococcosis
Pregnancy
HIV/AIDS
Autopsy
title Mediastinal cryptococcoma as part of disseminated cryptococcosis in HIV-negative pregnant woman with Myasthenia Gravis: Autopsy case report
title_full Mediastinal cryptococcoma as part of disseminated cryptococcosis in HIV-negative pregnant woman with Myasthenia Gravis: Autopsy case report
title_fullStr Mediastinal cryptococcoma as part of disseminated cryptococcosis in HIV-negative pregnant woman with Myasthenia Gravis: Autopsy case report
title_full_unstemmed Mediastinal cryptococcoma as part of disseminated cryptococcosis in HIV-negative pregnant woman with Myasthenia Gravis: Autopsy case report
title_short Mediastinal cryptococcoma as part of disseminated cryptococcosis in HIV-negative pregnant woman with Myasthenia Gravis: Autopsy case report
title_sort mediastinal cryptococcoma as part of disseminated cryptococcosis in hiv negative pregnant woman with myasthenia gravis autopsy case report
topic Myasthenia gravis
Cryptococcosis
Pregnancy
HIV/AIDS
Autopsy
url http://www.sciencedirect.com/science/article/pii/S2211753925000351
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