Crosstalk between MicroRNAs and Peroxisome Proliferator-Activated Receptors and Their Emerging Regulatory Roles in Cardiovascular Pathophysiology
Peroxisome proliferator-activated receptors (PPARs) play vital roles in cardiovascular pathophysiology, such as energy balance, cell proliferation/apoptosis, inflammatory response, and adipocyte differentiation. These vital roles make PPARs potential targets for therapeutic prevention of cardiovascu...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2018/8530371 |
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| author | Yin-Feng Zhang Hai-Ming Xu Fei Yu Man Wang Meng-Yang Li Tao Xu Yan-Yan Gao Jian-Xun Wang Pei-Feng Li |
| author_facet | Yin-Feng Zhang Hai-Ming Xu Fei Yu Man Wang Meng-Yang Li Tao Xu Yan-Yan Gao Jian-Xun Wang Pei-Feng Li |
| author_sort | Yin-Feng Zhang |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptors (PPARs) play vital roles in cardiovascular pathophysiology, such as energy balance, cell proliferation/apoptosis, inflammatory response, and adipocyte differentiation. These vital roles make PPARs potential targets for therapeutic prevention of cardiovascular diseases (CVDs). Emerging evidence indicates that the crosstalk of microRNAs (miRNAs) and PPARs contributes greatly to CVD pathogenesis. PPARs are inhibited by miRNAs at posttranscriptional mechanisms in the progress of pulmonary hypertension and vascular dysfunction involving cell proliferation/apoptosis, communication, and normal function of endothelial cells and vascular smooth muscle cells. In the development of atherosclerosis and stroke, the activation of PPARs could change the transcripts of target miRNA through miRNA signalling. Furthermore, the mutual regulation of PPARs and miRNAs involves cell proliferation/apoptosis, cardiac remodeling, and dysfunction in heart diseases. In addition, obesity, an important cardiovascular risk, is modulated by the regulatory axis of PPARs/miRNAs, including adipogenesis, adipocyte dysfunction, insulin resistance, and macrophage polarization in adipose tissue. In this review, the crosstalk of PPARs and miRNAs and their emerging regulatory roles are summarized in the context of CVDs and risks. This provides an understanding of the underlying mechanism of the biological process related to CVD pathophysiology involving the interaction of PPARs and miRNAs and will lead to the development of PPARs/miRNAs as effective anti-CVD medications. |
| format | Article |
| id | doaj-art-07bb1ea26354475eb16e9ea65c5b4630 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-07bb1ea26354475eb16e9ea65c5b46302025-02-03T01:11:07ZengWileyPPAR Research1687-47571687-47652018-01-01201810.1155/2018/85303718530371Crosstalk between MicroRNAs and Peroxisome Proliferator-Activated Receptors and Their Emerging Regulatory Roles in Cardiovascular PathophysiologyYin-Feng Zhang0Hai-Ming Xu1Fei Yu2Man Wang3Meng-Yang Li4Tao Xu5Yan-Yan Gao6Jian-Xun Wang7Pei-Feng Li8Institute for Translational Medicine, College of Medicine, Qingdao University, Deng Zhou Road 38, Qingdao 266021, ChinaDepartment of Occupational and Environmental Medicine, School of Public Health and Management, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, ChinaInstitute for Translational Medicine, College of Medicine, Qingdao University, Deng Zhou Road 38, Qingdao 266021, ChinaInstitute for Translational Medicine, College of Medicine, Qingdao University, Deng Zhou Road 38, Qingdao 266021, ChinaInstitute for Translational Medicine, College of Medicine, Qingdao University, Deng Zhou Road 38, Qingdao 266021, ChinaInstitute for Translational Medicine, College of Medicine, Qingdao University, Deng Zhou Road 38, Qingdao 266021, ChinaInstitute for Translational Medicine, College of Medicine, Qingdao University, Deng Zhou Road 38, Qingdao 266021, ChinaInstitute for Translational Medicine, College of Medicine, Qingdao University, Deng Zhou Road 38, Qingdao 266021, ChinaInstitute for Translational Medicine, College of Medicine, Qingdao University, Deng Zhou Road 38, Qingdao 266021, ChinaPeroxisome proliferator-activated receptors (PPARs) play vital roles in cardiovascular pathophysiology, such as energy balance, cell proliferation/apoptosis, inflammatory response, and adipocyte differentiation. These vital roles make PPARs potential targets for therapeutic prevention of cardiovascular diseases (CVDs). Emerging evidence indicates that the crosstalk of microRNAs (miRNAs) and PPARs contributes greatly to CVD pathogenesis. PPARs are inhibited by miRNAs at posttranscriptional mechanisms in the progress of pulmonary hypertension and vascular dysfunction involving cell proliferation/apoptosis, communication, and normal function of endothelial cells and vascular smooth muscle cells. In the development of atherosclerosis and stroke, the activation of PPARs could change the transcripts of target miRNA through miRNA signalling. Furthermore, the mutual regulation of PPARs and miRNAs involves cell proliferation/apoptosis, cardiac remodeling, and dysfunction in heart diseases. In addition, obesity, an important cardiovascular risk, is modulated by the regulatory axis of PPARs/miRNAs, including adipogenesis, adipocyte dysfunction, insulin resistance, and macrophage polarization in adipose tissue. In this review, the crosstalk of PPARs and miRNAs and their emerging regulatory roles are summarized in the context of CVDs and risks. This provides an understanding of the underlying mechanism of the biological process related to CVD pathophysiology involving the interaction of PPARs and miRNAs and will lead to the development of PPARs/miRNAs as effective anti-CVD medications.http://dx.doi.org/10.1155/2018/8530371 |
| spellingShingle | Yin-Feng Zhang Hai-Ming Xu Fei Yu Man Wang Meng-Yang Li Tao Xu Yan-Yan Gao Jian-Xun Wang Pei-Feng Li Crosstalk between MicroRNAs and Peroxisome Proliferator-Activated Receptors and Their Emerging Regulatory Roles in Cardiovascular Pathophysiology PPAR Research |
| title | Crosstalk between MicroRNAs and Peroxisome Proliferator-Activated Receptors and Their Emerging Regulatory Roles in Cardiovascular Pathophysiology |
| title_full | Crosstalk between MicroRNAs and Peroxisome Proliferator-Activated Receptors and Their Emerging Regulatory Roles in Cardiovascular Pathophysiology |
| title_fullStr | Crosstalk between MicroRNAs and Peroxisome Proliferator-Activated Receptors and Their Emerging Regulatory Roles in Cardiovascular Pathophysiology |
| title_full_unstemmed | Crosstalk between MicroRNAs and Peroxisome Proliferator-Activated Receptors and Their Emerging Regulatory Roles in Cardiovascular Pathophysiology |
| title_short | Crosstalk between MicroRNAs and Peroxisome Proliferator-Activated Receptors and Their Emerging Regulatory Roles in Cardiovascular Pathophysiology |
| title_sort | crosstalk between micrornas and peroxisome proliferator activated receptors and their emerging regulatory roles in cardiovascular pathophysiology |
| url | http://dx.doi.org/10.1155/2018/8530371 |
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