Inhibitory Effect of Probiotic Metabolites on Seborrheic Dermatitis and Acne-Related Pathogenic Bacteria
The topical application of probiotic metabolites has shown positive effects in the treatment of skin diseases; however, the effectiveness is strain dependent. Comparing the pathogen inhibitory effects of probiotic strains with different genetic backgrounds and analyzing their key metabolites can pro...
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MDPI AG
2024-12-01
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| Series: | Cosmetics |
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| Online Access: | https://www.mdpi.com/2079-9284/12/1/3 |
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| author | Qingpeng Meng Ciying Xiao Zejian Wang Yazhuo Shang |
| author_facet | Qingpeng Meng Ciying Xiao Zejian Wang Yazhuo Shang |
| author_sort | Qingpeng Meng |
| collection | DOAJ |
| description | The topical application of probiotic metabolites has shown positive effects in the treatment of skin diseases; however, the effectiveness is strain dependent. Comparing the pathogen inhibitory effects of probiotic strains with different genetic backgrounds and analyzing their key metabolites can provide insights about the potential of applying probiotics for skincare. In this study, we investigated the fermentation growth inhibition of 18 commercial probiotic strains on the skin pathogens <i>Malassezia furfur</i> (<i>M. furfur</i>) and <i>Cutibacterium acnes</i> (<i>C. acnes</i>) in vitro. We found that most <i>Bifidobacterium animalis</i> subsp. <i>lactis</i> (<i>B. lactis</i>) and <i>Lacticaseibacillus rhamnosus</i> (<i>L. rhamnosus</i>) strains exhibited strong inhibition of <i>M. furfur</i> and <i>C. acnes</i>, which lasted up to 100 h. The main antibacterial metabolites observed were molecules below 10,000 Da in molecular weight, including peptides and organic acids (lactic acid, acetic acid, propionic acid, and butyric acid). The synergistic effect of organic acid combinations lowered the minimum inhibitory concentration (MIC). The composition of these antimicrobial metabolites varied among strains, which demonstrated the strain-dependent pathogenic inhibitory effects. This study provides insights into the application potential of using probiotic metabolites against seborrheic dermatitis and acne-related pathogenic bacteria. |
| format | Article |
| id | doaj-art-07bb09b3e13242d0ba9624e3903f3df3 |
| institution | DOAJ |
| issn | 2079-9284 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cosmetics |
| spelling | doaj-art-07bb09b3e13242d0ba9624e3903f3df32025-08-20T02:44:59ZengMDPI AGCosmetics2079-92842024-12-01121310.3390/cosmetics12010003Inhibitory Effect of Probiotic Metabolites on Seborrheic Dermatitis and Acne-Related Pathogenic BacteriaQingpeng Meng0Ciying Xiao1Zejian Wang2Yazhuo Shang3School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, ChinaSchool of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, ChinaSchool of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, ChinaSchool of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, ChinaThe topical application of probiotic metabolites has shown positive effects in the treatment of skin diseases; however, the effectiveness is strain dependent. Comparing the pathogen inhibitory effects of probiotic strains with different genetic backgrounds and analyzing their key metabolites can provide insights about the potential of applying probiotics for skincare. In this study, we investigated the fermentation growth inhibition of 18 commercial probiotic strains on the skin pathogens <i>Malassezia furfur</i> (<i>M. furfur</i>) and <i>Cutibacterium acnes</i> (<i>C. acnes</i>) in vitro. We found that most <i>Bifidobacterium animalis</i> subsp. <i>lactis</i> (<i>B. lactis</i>) and <i>Lacticaseibacillus rhamnosus</i> (<i>L. rhamnosus</i>) strains exhibited strong inhibition of <i>M. furfur</i> and <i>C. acnes</i>, which lasted up to 100 h. The main antibacterial metabolites observed were molecules below 10,000 Da in molecular weight, including peptides and organic acids (lactic acid, acetic acid, propionic acid, and butyric acid). The synergistic effect of organic acid combinations lowered the minimum inhibitory concentration (MIC). The composition of these antimicrobial metabolites varied among strains, which demonstrated the strain-dependent pathogenic inhibitory effects. This study provides insights into the application potential of using probiotic metabolites against seborrheic dermatitis and acne-related pathogenic bacteria.https://www.mdpi.com/2079-9284/12/1/3probioticsskin microbiome<i>Malassezia furfur</i><i>Propionibacterium acnes</i>antibacterialmetabolites |
| spellingShingle | Qingpeng Meng Ciying Xiao Zejian Wang Yazhuo Shang Inhibitory Effect of Probiotic Metabolites on Seborrheic Dermatitis and Acne-Related Pathogenic Bacteria Cosmetics probiotics skin microbiome <i>Malassezia furfur</i> <i>Propionibacterium acnes</i> antibacterial metabolites |
| title | Inhibitory Effect of Probiotic Metabolites on Seborrheic Dermatitis and Acne-Related Pathogenic Bacteria |
| title_full | Inhibitory Effect of Probiotic Metabolites on Seborrheic Dermatitis and Acne-Related Pathogenic Bacteria |
| title_fullStr | Inhibitory Effect of Probiotic Metabolites on Seborrheic Dermatitis and Acne-Related Pathogenic Bacteria |
| title_full_unstemmed | Inhibitory Effect of Probiotic Metabolites on Seborrheic Dermatitis and Acne-Related Pathogenic Bacteria |
| title_short | Inhibitory Effect of Probiotic Metabolites on Seborrheic Dermatitis and Acne-Related Pathogenic Bacteria |
| title_sort | inhibitory effect of probiotic metabolites on seborrheic dermatitis and acne related pathogenic bacteria |
| topic | probiotics skin microbiome <i>Malassezia furfur</i> <i>Propionibacterium acnes</i> antibacterial metabolites |
| url | https://www.mdpi.com/2079-9284/12/1/3 |
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