Fenofibrate Therapy in Carnitine Palmitoyl Transferase Type 2 Deficiency
Bezafibrate therapy has been shown to improve beta-oxidation of fatty acids and to reduce episodes of rhabdomyolysis in patients with carnitine palmitoyltransferase type-2 (CPT2) deficiency. We report the efficacy of fenofibrate in a patient with CPT2 deficiency, in whom beta-oxidation was improved...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/163173 |
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| author | I. Hamilton-Craig M. Yudi L. Johnson R. Jayasinghe |
| author_facet | I. Hamilton-Craig M. Yudi L. Johnson R. Jayasinghe |
| author_sort | I. Hamilton-Craig |
| collection | DOAJ |
| description | Bezafibrate therapy has been shown to improve beta-oxidation of fatty acids and to reduce episodes of rhabdomyolysis in patients with carnitine palmitoyltransferase type-2 (CPT2) deficiency. We report the efficacy of fenofibrate in a patient with CPT2 deficiency, in whom beta-oxidation was improved but an episode of rhabdomyolysis nevertheless occurred. This suggests additional methods to avoid rhabdomyolysis in patients with CPT2 deficiency should accompany fibrate therapy, including avoidance of muscular overexertion, dehydration, and heat exposure. |
| format | Article |
| id | doaj-art-07b745c8eb3b493491d055de37d620b1 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-07b745c8eb3b493491d055de37d620b12025-02-03T01:12:11ZengWileyCase Reports in Medicine1687-96271687-96352012-01-01201210.1155/2012/163173163173Fenofibrate Therapy in Carnitine Palmitoyl Transferase Type 2 DeficiencyI. Hamilton-Craig0M. Yudi1L. Johnson2R. Jayasinghe3Griffith University School of Medicine and Gold Coast University Hospital, Southport, Gold Coast, QLD 4215, AustraliaRoyal Australasian College of Physicians and Royal Melbourne Hospital, Parkville, Melbourne, VIC 3050, AustraliaPathology Queensland, Royal Brisbane and Women’s Hospital, Brisbane, QLD 4029, AustraliaDepartment of Cardiology, Gold Coast University Hospital, Griffith University, Southport, Gold Coast, QLD 4215, AustraliaBezafibrate therapy has been shown to improve beta-oxidation of fatty acids and to reduce episodes of rhabdomyolysis in patients with carnitine palmitoyltransferase type-2 (CPT2) deficiency. We report the efficacy of fenofibrate in a patient with CPT2 deficiency, in whom beta-oxidation was improved but an episode of rhabdomyolysis nevertheless occurred. This suggests additional methods to avoid rhabdomyolysis in patients with CPT2 deficiency should accompany fibrate therapy, including avoidance of muscular overexertion, dehydration, and heat exposure.http://dx.doi.org/10.1155/2012/163173 |
| spellingShingle | I. Hamilton-Craig M. Yudi L. Johnson R. Jayasinghe Fenofibrate Therapy in Carnitine Palmitoyl Transferase Type 2 Deficiency Case Reports in Medicine |
| title | Fenofibrate Therapy in Carnitine Palmitoyl Transferase Type 2 Deficiency |
| title_full | Fenofibrate Therapy in Carnitine Palmitoyl Transferase Type 2 Deficiency |
| title_fullStr | Fenofibrate Therapy in Carnitine Palmitoyl Transferase Type 2 Deficiency |
| title_full_unstemmed | Fenofibrate Therapy in Carnitine Palmitoyl Transferase Type 2 Deficiency |
| title_short | Fenofibrate Therapy in Carnitine Palmitoyl Transferase Type 2 Deficiency |
| title_sort | fenofibrate therapy in carnitine palmitoyl transferase type 2 deficiency |
| url | http://dx.doi.org/10.1155/2012/163173 |
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