Computationally designed haemagglutinin with nanocage plug-and-display elicits pan-H5 influenza vaccine responses

Computationally designed haemagglutinin with nanocage plug-and-display elicits pan-H5 influenza vaccine responses

The increasing spread of highly pathogenic avian influenza (HPAI) A/H5 viruses poses a pandemic threat. Circulating clade 2.3.4.4b viruses have demonstrated rapid transcontinental dissemination, extensive reassortment, epizootic spread and potential sustained mammal-to-mammal transmission, signifyin...

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Bibliographic Details
Main Authors: Chloe Qingzhou Huang, Rory A. Hills, George W. Carnell, Sneha Vishwanath, Ernest T. Aguinam, Andrew C.Y. Chan, Phil Palmer, Laura O’Reilly, Paul Tonks, Nigel Temperton, Simon D.W. Frost, Laurence S. Tiley, Mark R. Howarth, Jonathan L. Heeney
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Emerging Microbes and Infections
Subjects:
Avian influenza
universal influenza vaccine
pandemic preparedness
protein engineering
virus-like particles
nanoparticles
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2025.2511132
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