Platelets and platelet-derived growth factor in closure of the ductus arteriosus
The crucial role of platelets in the permanent closure of the ductus arteriosus has recently been elucidated in an animal model; however, clinical studies investigating the impact of platelet count on ductal patency have conflicting results. Our aim is to compare platelet count, indices and s...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2015-06-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/1231 |
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| author | Defne Engür Münevver Kaynak-Türkmen Murat Deveci Çiğdem Yenisey |
| author_facet | Defne Engür Münevver Kaynak-Türkmen Murat Deveci Çiğdem Yenisey |
| author_sort | Defne Engür |
| collection | DOAJ |
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The crucial role of platelets in the permanent closure of the ductus arteriosus has recently been elucidated in an animal model; however, clinical studies investigating the impact of platelet count on ductal patency have conflicting results. Our aim is to compare platelet count, indices and serum platelet-derived growth factor levels in preterms with and without ductal patency. Preterms with a gestational age of 27-30 weeks followed up during a twelve-month period in the neonatal intensive care unit of Adnan Menderes University Hospital were enrolled. Infants underwent echocardiographic evaluation starting on the second day and subsequently assessed every other day until ductal closure was achieved, or upon clinical signs of reopening. Platelet-derived growth factor was measured on the second and fifth days of life. Eleven very low birth weight infants who subsequently required medical treatment for patent ductus arteriosus were compared with twenty-three infants with closed ductus. Although platelet count and indices were similar, median serum plateletderived growth factor levels on day 5 were significantly lower among babies who subsequently required medical treatment for ductal patency (874.6 vs 1099.6 pg/ml). The current study points out a possible association between serum platelet-derived growth factor levels and ductal closure. Our results suggest that platelet-derived growth factor may play a role in ductal closure independent from platelet count and might be used as an adjunct surrogate for prediction of future need for treatment for hemodynamically significant patent ductus arteriosus in preterm infants.
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| format | Article |
| id | doaj-art-07aae4e7609b4b388a3bf5477394a63e |
| institution | OA Journals |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2015-06-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-07aae4e7609b4b388a3bf5477394a63e2025-08-20T02:01:47ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212015-06-01573Platelets and platelet-derived growth factor in closure of the ductus arteriosusDefne Engür0Münevver Kaynak-TürkmenMurat DeveciÇiğdem YeniseyDivision of Neonatolog, Department of Pediatrics, Adnan Menderes University Faculty of Medicine, Aydın, Turkey. defneka@hotmail.com. The crucial role of platelets in the permanent closure of the ductus arteriosus has recently been elucidated in an animal model; however, clinical studies investigating the impact of platelet count on ductal patency have conflicting results. Our aim is to compare platelet count, indices and serum platelet-derived growth factor levels in preterms with and without ductal patency. Preterms with a gestational age of 27-30 weeks followed up during a twelve-month period in the neonatal intensive care unit of Adnan Menderes University Hospital were enrolled. Infants underwent echocardiographic evaluation starting on the second day and subsequently assessed every other day until ductal closure was achieved, or upon clinical signs of reopening. Platelet-derived growth factor was measured on the second and fifth days of life. Eleven very low birth weight infants who subsequently required medical treatment for patent ductus arteriosus were compared with twenty-three infants with closed ductus. Although platelet count and indices were similar, median serum plateletderived growth factor levels on day 5 were significantly lower among babies who subsequently required medical treatment for ductal patency (874.6 vs 1099.6 pg/ml). The current study points out a possible association between serum platelet-derived growth factor levels and ductal closure. Our results suggest that platelet-derived growth factor may play a role in ductal closure independent from platelet count and might be used as an adjunct surrogate for prediction of future need for treatment for hemodynamically significant patent ductus arteriosus in preterm infants. https://turkjpediatr.org/article/view/1231 |
| spellingShingle | Defne Engür Münevver Kaynak-Türkmen Murat Deveci Çiğdem Yenisey Platelets and platelet-derived growth factor in closure of the ductus arteriosus The Turkish Journal of Pediatrics |
| title | Platelets and platelet-derived growth factor in closure of the ductus arteriosus |
| title_full | Platelets and platelet-derived growth factor in closure of the ductus arteriosus |
| title_fullStr | Platelets and platelet-derived growth factor in closure of the ductus arteriosus |
| title_full_unstemmed | Platelets and platelet-derived growth factor in closure of the ductus arteriosus |
| title_short | Platelets and platelet-derived growth factor in closure of the ductus arteriosus |
| title_sort | platelets and platelet derived growth factor in closure of the ductus arteriosus |
| url | https://turkjpediatr.org/article/view/1231 |
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