IMMUNOMODULATORY ACTION OF MYELOPIDUM UNDER ITS INCLUSION IN COMPLEX THERAPY OF PATIENTS WITH PENETRATING OCULAR INJURIES
Abstract. Examination of immunomodulatory actions and clinical efficiency of myelopidum when included into complex therapy that was carried out in 24 male patients with severe (stage 3) penetrating eye injury in the course of trauma treatment. The levels of C-reactive protein, lactoferrin, interleuk...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
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| Online Access: | https://www.mimmun.ru/mimmun/article/view/158 |
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| author | T. V. Gavrilova V. V. Chuprina E. V. Davydova Ju. I. Shilov M. V. Chereshneva V. A. Chereshnev |
| author_facet | T. V. Gavrilova V. V. Chuprina E. V. Davydova Ju. I. Shilov M. V. Chereshneva V. A. Chereshnev |
| author_sort | T. V. Gavrilova |
| collection | DOAJ |
| description | Abstract. Examination of immunomodulatory actions and clinical efficiency of myelopidum when included into complex therapy that was carried out in 24 male patients with severe (stage 3) penetrating eye injury in the course of trauma treatment. The levels of C-reactive protein, lactoferrin, interleukin (IL)-1β, IL-6, and activity of complement system were measured in peripheral blood, and concentrations of lactoferrin and IL-8 were determined in tears. An increase in lactoferrin, C-reactive protein, IL-1β, IL-8, and C5 complement component levels was detected during early post-traumatic period, as compared with data from the control group. As compared to effects of steroid and non-steroid anti-inflammatory drugs included into standard therapy, treatment with myelopidum has led to a more favorable clinical course of traumatic process, and resulted into more pronounced anti-inflammatory effect that was manifested by decrease in lactoferrin and C-reactive protein levels, reduction of IL-1β concentration, and C5 complement component activity. (Med. Immunol., 2008, vol. 10, N 2-3, pp 239-244). |
| format | Article |
| id | doaj-art-07a86f8cced44906b84a890610e44cd2 |
| institution | Kabale University |
| issn | 1563-0625 2313-741X |
| language | Russian |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj-art-07a86f8cced44906b84a890610e44cd22025-08-20T03:44:07ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01102-323924410.15789/1563-0625-2008-2-3-239-244155IMMUNOMODULATORY ACTION OF MYELOPIDUM UNDER ITS INCLUSION IN COMPLEX THERAPY OF PATIENTS WITH PENETRATING OCULAR INJURIEST. V. Gavrilova0V. V. Chuprina1E. V. Davydova2Ju. I. Shilov3M. V. Chereshneva4V. A. Chereshnev5Институт экологии и генетики микроорганизмов УрО РАН, г. Пермь; ГОУ ВПО «Пермская государственная медицинская академия им. акад. Е.А. Вагнера Росздрава», г. ПермьГОУ ВПО «Пермская государственная медицинская академия им. акад. Е.А. Вагнера Росздрава», г. ПермьИнститут иммунологии и физиологии УрО РАН, г. ЕкатеринбургИнститут экологии и генетики микроорганизмов УрО РАН, г. ПермьИнститут иммунологии и физиологии УрО РАН, г. ЕкатеринбургИнститут экологии и генетики микроорганизмов УрО РАН, г. Пермь; Институт иммунологии и физиологии УрО РАН, г. ЕкатеринбургAbstract. Examination of immunomodulatory actions and clinical efficiency of myelopidum when included into complex therapy that was carried out in 24 male patients with severe (stage 3) penetrating eye injury in the course of trauma treatment. The levels of C-reactive protein, lactoferrin, interleukin (IL)-1β, IL-6, and activity of complement system were measured in peripheral blood, and concentrations of lactoferrin and IL-8 were determined in tears. An increase in lactoferrin, C-reactive protein, IL-1β, IL-8, and C5 complement component levels was detected during early post-traumatic period, as compared with data from the control group. As compared to effects of steroid and non-steroid anti-inflammatory drugs included into standard therapy, treatment with myelopidum has led to a more favorable clinical course of traumatic process, and resulted into more pronounced anti-inflammatory effect that was manifested by decrease in lactoferrin and C-reactive protein levels, reduction of IL-1β concentration, and C5 complement component activity. (Med. Immunol., 2008, vol. 10, N 2-3, pp 239-244).https://www.mimmun.ru/mimmun/article/view/158myelopidumpenetrating eye injuryacute phase proteinscytokinescomplement system |
| spellingShingle | T. V. Gavrilova V. V. Chuprina E. V. Davydova Ju. I. Shilov M. V. Chereshneva V. A. Chereshnev IMMUNOMODULATORY ACTION OF MYELOPIDUM UNDER ITS INCLUSION IN COMPLEX THERAPY OF PATIENTS WITH PENETRATING OCULAR INJURIES Медицинская иммунология myelopidum penetrating eye injury acute phase proteins cytokines complement system |
| title | IMMUNOMODULATORY ACTION OF MYELOPIDUM UNDER ITS INCLUSION IN COMPLEX THERAPY OF PATIENTS WITH PENETRATING OCULAR INJURIES |
| title_full | IMMUNOMODULATORY ACTION OF MYELOPIDUM UNDER ITS INCLUSION IN COMPLEX THERAPY OF PATIENTS WITH PENETRATING OCULAR INJURIES |
| title_fullStr | IMMUNOMODULATORY ACTION OF MYELOPIDUM UNDER ITS INCLUSION IN COMPLEX THERAPY OF PATIENTS WITH PENETRATING OCULAR INJURIES |
| title_full_unstemmed | IMMUNOMODULATORY ACTION OF MYELOPIDUM UNDER ITS INCLUSION IN COMPLEX THERAPY OF PATIENTS WITH PENETRATING OCULAR INJURIES |
| title_short | IMMUNOMODULATORY ACTION OF MYELOPIDUM UNDER ITS INCLUSION IN COMPLEX THERAPY OF PATIENTS WITH PENETRATING OCULAR INJURIES |
| title_sort | immunomodulatory action of myelopidum under its inclusion in complex therapy of patients with penetrating ocular injuries |
| topic | myelopidum penetrating eye injury acute phase proteins cytokines complement system |
| url | https://www.mimmun.ru/mimmun/article/view/158 |
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