Evaluation of Osteoconductive and Osteogenic Potential of a Dentin-Based Bone Substitute Using a Calvarial Defect Model
The aim of this study was to assess the osteoconductive and osteogenic properties of processed bovine dentin using a robust rabbit calvarial defect model. In total, 16 New Zealand White rabbits were operated to create three circular defects in the calvaria. One defect was left unfilled, one filled w...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2012/396316 |
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| author | Ibrahim Hussain Keyvan Moharamzadeh Ian M. Brook Patrício José de Oliveira Neto Luiz A. Salata |
| author_facet | Ibrahim Hussain Keyvan Moharamzadeh Ian M. Brook Patrício José de Oliveira Neto Luiz A. Salata |
| author_sort | Ibrahim Hussain |
| collection | DOAJ |
| description | The aim of this study was to assess the osteoconductive and osteogenic properties of processed bovine dentin using a robust rabbit calvarial defect model. In total, 16 New Zealand White rabbits were operated to create three circular defects in the calvaria. One defect was left unfilled, one filled with collected autogenous bone, and the third defect was filled with the dentin-based bone substitute. Following surgery and after a healing period of either 1 or 6 weeks, a CT scan was obtained. Following sacrificing, the tissues were processed for histological examination. The CT data showed the density in the area grafted with the dentin-based material was higher than the surrounding bone and the areas grafted with autologous bone after 1 week and 6 weeks of healing. The area left unfilled remained an empty defect after 1 week and 6 weeks. Histological examination of the defects filled with the dentin product after 6 weeks showed soft tissue encapsulation around the dentin particles. It can be concluded that the rabbit calvarial model used in this study is a robust model for the assessment of bone materials. Bovine dentin is a biostable material; however, it may not be suitable for repairing large 4-wall defects. |
| format | Article |
| id | doaj-art-07a83eaf9d694c2aab79a981c028b261 |
| institution | OA Journals |
| issn | 1687-8728 1687-8736 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-07a83eaf9d694c2aab79a981c028b2612025-08-20T02:01:34ZengWileyInternational Journal of Dentistry1687-87281687-87362012-01-01201210.1155/2012/396316396316Evaluation of Osteoconductive and Osteogenic Potential of a Dentin-Based Bone Substitute Using a Calvarial Defect ModelIbrahim Hussain0Keyvan Moharamzadeh1Ian M. Brook2Patrício José de Oliveira Neto3Luiz A. Salata4School of Clinical Dentistry, The University of Sheffield, Claremont Crescent, Sheffield S10 2TA, UKSchool of Clinical Dentistry, The University of Sheffield, Claremont Crescent, Sheffield S10 2TA, UKSchool of Clinical Dentistry, The University of Sheffield, Claremont Crescent, Sheffield S10 2TA, UKDepartment of Oral and Maxillofacial Surgery and Periodontics, Faculty of Dentistry of Ribeirao Preto, University of São Paulo, Avenida do Cafe s/n—Campus USP, 14040-904 Ribeirão Preto, SP, BrazilDepartment of Oral and Maxillofacial Surgery and Periodontics, Faculty of Dentistry of Ribeirao Preto, University of São Paulo, Avenida do Cafe s/n—Campus USP, 14040-904 Ribeirão Preto, SP, BrazilThe aim of this study was to assess the osteoconductive and osteogenic properties of processed bovine dentin using a robust rabbit calvarial defect model. In total, 16 New Zealand White rabbits were operated to create three circular defects in the calvaria. One defect was left unfilled, one filled with collected autogenous bone, and the third defect was filled with the dentin-based bone substitute. Following surgery and after a healing period of either 1 or 6 weeks, a CT scan was obtained. Following sacrificing, the tissues were processed for histological examination. The CT data showed the density in the area grafted with the dentin-based material was higher than the surrounding bone and the areas grafted with autologous bone after 1 week and 6 weeks of healing. The area left unfilled remained an empty defect after 1 week and 6 weeks. Histological examination of the defects filled with the dentin product after 6 weeks showed soft tissue encapsulation around the dentin particles. It can be concluded that the rabbit calvarial model used in this study is a robust model for the assessment of bone materials. Bovine dentin is a biostable material; however, it may not be suitable for repairing large 4-wall defects.http://dx.doi.org/10.1155/2012/396316 |
| spellingShingle | Ibrahim Hussain Keyvan Moharamzadeh Ian M. Brook Patrício José de Oliveira Neto Luiz A. Salata Evaluation of Osteoconductive and Osteogenic Potential of a Dentin-Based Bone Substitute Using a Calvarial Defect Model International Journal of Dentistry |
| title | Evaluation of Osteoconductive and Osteogenic Potential of a Dentin-Based Bone Substitute Using a Calvarial Defect Model |
| title_full | Evaluation of Osteoconductive and Osteogenic Potential of a Dentin-Based Bone Substitute Using a Calvarial Defect Model |
| title_fullStr | Evaluation of Osteoconductive and Osteogenic Potential of a Dentin-Based Bone Substitute Using a Calvarial Defect Model |
| title_full_unstemmed | Evaluation of Osteoconductive and Osteogenic Potential of a Dentin-Based Bone Substitute Using a Calvarial Defect Model |
| title_short | Evaluation of Osteoconductive and Osteogenic Potential of a Dentin-Based Bone Substitute Using a Calvarial Defect Model |
| title_sort | evaluation of osteoconductive and osteogenic potential of a dentin based bone substitute using a calvarial defect model |
| url | http://dx.doi.org/10.1155/2012/396316 |
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