Dietary Fatty Acids and Predementia Syndromes
An increasing body of epidemiological evidence suggests that elevated saturated fatty acids (SFA) could have negative effects on age-related cognitive decline (ARCD). Furthermore, a reduction of risk for cognitive decline and mild cognitive impairment (MCI) has been found in population samples with...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2009.82 |
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| author | Vincenzo Solfrizzi Vincenza Frisardi Cristiano Capurso Alessia D' Introno Anna M. Colacicco Gianluigi Vendemiale Antonio Capurso Francesco Panza |
| author_facet | Vincenzo Solfrizzi Vincenza Frisardi Cristiano Capurso Alessia D' Introno Anna M. Colacicco Gianluigi Vendemiale Antonio Capurso Francesco Panza |
| author_sort | Vincenzo Solfrizzi |
| collection | DOAJ |
| description | An increasing body of epidemiological evidence suggests that elevated saturated fatty acids (SFA) could have negative effects on age-related cognitive decline (ARCD). Furthermore, a reduction of risk for cognitive decline and mild cognitive impairment (MCI) has been found in population samples with elevated fish consumption, and high intake of monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA), particularly n-3 PUFA. However, recent findings from clinical trials with n-3 PUFA supplementation showed efficacy on depressive symptoms in non–Vapolipoprotein E (APOE) ε4 carriers, and on cognitive symptoms only in very mild Alzheimer's disease (AD) subgroups, MCI patients, and cognitively unimpaired non-APOE ε4 carriers. These data, together with epidemiological evidence, support the idea that n-3 PUFA may play a role in maintaining adequate cognitive functioning in predementia syndromes, but not when the AD process has already taken over. Therefore, at present, no definitive dietary recommendations on fish and unsaturated fatty acids consumption, or lower intake of saturated fat, in relation to the risk for dementia and cognitive decline are possible. |
| format | Article |
| id | doaj-art-07a6e278e2854c6dbe6983bfed8738e6 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-07a6e278e2854c6dbe6983bfed8738e62025-02-03T01:03:04ZengWileyThe Scientific World Journal1537-744X2009-01-01979281010.1100/tsw.2009.82Dietary Fatty Acids and Predementia SyndromesVincenzo Solfrizzi0Vincenza Frisardi1Cristiano Capurso2Alessia D' Introno3Anna M. Colacicco4Gianluigi Vendemiale5Antonio Capurso6Francesco Panza7Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, ItalyDepartment of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, ItalyDepartment of Geriatrics, University of Foggia, ItalyDepartment of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, ItalyDepartment of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, ItalyDepartment of Geriatrics, University of Foggia, ItalyDepartment of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, ItalyDepartment of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, ItalyAn increasing body of epidemiological evidence suggests that elevated saturated fatty acids (SFA) could have negative effects on age-related cognitive decline (ARCD). Furthermore, a reduction of risk for cognitive decline and mild cognitive impairment (MCI) has been found in population samples with elevated fish consumption, and high intake of monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA), particularly n-3 PUFA. However, recent findings from clinical trials with n-3 PUFA supplementation showed efficacy on depressive symptoms in non–Vapolipoprotein E (APOE) ε4 carriers, and on cognitive symptoms only in very mild Alzheimer's disease (AD) subgroups, MCI patients, and cognitively unimpaired non-APOE ε4 carriers. These data, together with epidemiological evidence, support the idea that n-3 PUFA may play a role in maintaining adequate cognitive functioning in predementia syndromes, but not when the AD process has already taken over. Therefore, at present, no definitive dietary recommendations on fish and unsaturated fatty acids consumption, or lower intake of saturated fat, in relation to the risk for dementia and cognitive decline are possible.http://dx.doi.org/10.1100/tsw.2009.82 |
| spellingShingle | Vincenzo Solfrizzi Vincenza Frisardi Cristiano Capurso Alessia D' Introno Anna M. Colacicco Gianluigi Vendemiale Antonio Capurso Francesco Panza Dietary Fatty Acids and Predementia Syndromes The Scientific World Journal |
| title | Dietary Fatty Acids and Predementia Syndromes |
| title_full | Dietary Fatty Acids and Predementia Syndromes |
| title_fullStr | Dietary Fatty Acids and Predementia Syndromes |
| title_full_unstemmed | Dietary Fatty Acids and Predementia Syndromes |
| title_short | Dietary Fatty Acids and Predementia Syndromes |
| title_sort | dietary fatty acids and predementia syndromes |
| url | http://dx.doi.org/10.1100/tsw.2009.82 |
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