Non-Invasive in vivo Imaging in Small Animal Research
Non-invasive real time in vivo molecular imaging in small animal models has become the essential bridge between in vitro data and their translation into clinical applications. The tremendous development and technological progress, such as tumour modelling, monitoring of tumour growth and detection o...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2006-01-01
|
| Series: | Cellular Oncology |
| Online Access: | http://dx.doi.org/10.1155/2006/245619 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850233785577111552 |
|---|---|
| author | V. Koo P. W. Hamilton K. Williamson |
| author_facet | V. Koo P. W. Hamilton K. Williamson |
| author_sort | V. Koo |
| collection | DOAJ |
| description | Non-invasive real time in vivo molecular imaging in small animal models has become the essential bridge between in vitro data and their translation into clinical applications. The tremendous development and technological progress, such as tumour modelling, monitoring of tumour growth and detection of metastasis, has facilitated translational drug development. This has added to our knowledge on carcinogenesis. The modalities that are commonly used include Magnetic Resonance Imaging (MRI), Computed Tomography (CT), Positron Emission Tomography (PET), bioluminescence imaging, fluorescence imaging and multi-modality imaging systems. The ability to obtain multiple images longitudinally provides reliable information whilst reducing animal numbers. As yet there is no one modality that is ideal for all experimental studies. This review outlines the instrumentation available together with corresponding applications reported in the literature with particular emphasis on cancer research. Advantages and limitations to current imaging technology are discussed and the issues concerning small animal care during imaging are highlighted. |
| format | Article |
| id | doaj-art-079fcbdd1dd44804bec222a492e03255 |
| institution | OA Journals |
| issn | 1570-5870 1875-8606 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cellular Oncology |
| spelling | doaj-art-079fcbdd1dd44804bec222a492e032552025-08-20T02:02:50ZengWileyCellular Oncology1570-58701875-86062006-01-0128412713910.1155/2006/245619Non-Invasive in vivo Imaging in Small Animal ResearchV. Koo0P. W. Hamilton1K. Williamson2Uro-oncology Research Group, Queen's University Belfast, Northern Ireland, UKBio-Imaging & Informatics Research Group Centre Cancer Research & Cell Biology, Queen's University Belfast, Northern Ireland, UKUro-oncology Research Group, Queen's University Belfast, Northern Ireland, UKNon-invasive real time in vivo molecular imaging in small animal models has become the essential bridge between in vitro data and their translation into clinical applications. The tremendous development and technological progress, such as tumour modelling, monitoring of tumour growth and detection of metastasis, has facilitated translational drug development. This has added to our knowledge on carcinogenesis. The modalities that are commonly used include Magnetic Resonance Imaging (MRI), Computed Tomography (CT), Positron Emission Tomography (PET), bioluminescence imaging, fluorescence imaging and multi-modality imaging systems. The ability to obtain multiple images longitudinally provides reliable information whilst reducing animal numbers. As yet there is no one modality that is ideal for all experimental studies. This review outlines the instrumentation available together with corresponding applications reported in the literature with particular emphasis on cancer research. Advantages and limitations to current imaging technology are discussed and the issues concerning small animal care during imaging are highlighted.http://dx.doi.org/10.1155/2006/245619 |
| spellingShingle | V. Koo P. W. Hamilton K. Williamson Non-Invasive in vivo Imaging in Small Animal Research Cellular Oncology |
| title | Non-Invasive in vivo Imaging in Small Animal Research |
| title_full | Non-Invasive in vivo Imaging in Small Animal Research |
| title_fullStr | Non-Invasive in vivo Imaging in Small Animal Research |
| title_full_unstemmed | Non-Invasive in vivo Imaging in Small Animal Research |
| title_short | Non-Invasive in vivo Imaging in Small Animal Research |
| title_sort | non invasive in vivo imaging in small animal research |
| url | http://dx.doi.org/10.1155/2006/245619 |
| work_keys_str_mv | AT vkoo noninvasiveinvivoimaginginsmallanimalresearch AT pwhamilton noninvasiveinvivoimaginginsmallanimalresearch AT kwilliamson noninvasiveinvivoimaginginsmallanimalresearch |