Associations of Ureaplasma urealyticum infection with male infertility and intrauterine insemination outcomes
Ureaplasma urealyticum (UU) is one of the most commonly occurring pathogens associated with genital tract infections in infertile males, but the impact of seminal UU infection in semen on intrauterine insemination (IUI) outcomes is poorly understood. We collected data from 245 infertile couples who...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-03-01
|
| Series: | Asian Journal of Andrology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/aja202489 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850037239825825792 |
|---|---|
| author | Yang-Yang Wan Xiao-Yun Shi Wen-Jing Liu Shun Bai Xin Chen Si-Yao Li Xiao-Hua Jiang Li-Min Wu Xian-Sheng Zhang Juan Hua |
| author_facet | Yang-Yang Wan Xiao-Yun Shi Wen-Jing Liu Shun Bai Xin Chen Si-Yao Li Xiao-Hua Jiang Li-Min Wu Xian-Sheng Zhang Juan Hua |
| author_sort | Yang-Yang Wan |
| collection | DOAJ |
| description | Ureaplasma urealyticum (UU) is one of the most commonly occurring pathogens associated with genital tract infections in infertile males, but the impact of seminal UU infection in semen on intrauterine insemination (IUI) outcomes is poorly understood. We collected data from 245 infertile couples who underwent IUI at The First Affiliated Hospital of USTC (Hefei, China) between January 2021 and January 2023. The subjects were classified into two groups according to their UU infection status: the UU-positive group and the UU-negative group. We compared semen parameters, pregnancy outcomes, and neonatal birth outcomes to investigate the impact of UU infection on IUI outcomes. There were no significantly statistical differences in various semen parameters, including semen volume, sperm concentration, total and progressive motility, sperm morphology, leukocyte count, the presence of anti-sperm antibody, and sperm DNA fragmentation index (DFI), between the UU-positive and UU-negative groups of male infertile patients (all P > 0.05). However, the high DNA stainability (HDS) status of sperm differed between the UU-positive and UU-negative groups, suggesting that seminal UU infection may affect sperm nuclear maturation (P = 0.04). Additionally, there were no significant differences in pregnancy or neonatal birth outcomes between the two groups (all P > 0.05). These results suggest that IUI remains a viable and cost-effective option for infertile couples with UU infection who are facing infertility issues. |
| format | Article |
| id | doaj-art-079bf3e1674e4c06906b47dc7aa5a88b |
| institution | DOAJ |
| issn | 1008-682X 1745-7262 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Andrology |
| spelling | doaj-art-079bf3e1674e4c06906b47dc7aa5a88b2025-08-20T02:56:55ZengWolters Kluwer Medknow PublicationsAsian Journal of Andrology1008-682X1745-72622025-03-0127221922410.4103/aja202489Associations of Ureaplasma urealyticum infection with male infertility and intrauterine insemination outcomesYang-Yang WanXiao-Yun ShiWen-Jing LiuShun BaiXin ChenSi-Yao LiXiao-Hua JiangLi-Min WuXian-Sheng ZhangJuan HuaUreaplasma urealyticum (UU) is one of the most commonly occurring pathogens associated with genital tract infections in infertile males, but the impact of seminal UU infection in semen on intrauterine insemination (IUI) outcomes is poorly understood. We collected data from 245 infertile couples who underwent IUI at The First Affiliated Hospital of USTC (Hefei, China) between January 2021 and January 2023. The subjects were classified into two groups according to their UU infection status: the UU-positive group and the UU-negative group. We compared semen parameters, pregnancy outcomes, and neonatal birth outcomes to investigate the impact of UU infection on IUI outcomes. There were no significantly statistical differences in various semen parameters, including semen volume, sperm concentration, total and progressive motility, sperm morphology, leukocyte count, the presence of anti-sperm antibody, and sperm DNA fragmentation index (DFI), between the UU-positive and UU-negative groups of male infertile patients (all P > 0.05). However, the high DNA stainability (HDS) status of sperm differed between the UU-positive and UU-negative groups, suggesting that seminal UU infection may affect sperm nuclear maturation (P = 0.04). Additionally, there were no significant differences in pregnancy or neonatal birth outcomes between the two groups (all P > 0.05). These results suggest that IUI remains a viable and cost-effective option for infertile couples with UU infection who are facing infertility issues.https://journals.lww.com/10.4103/aja202489intrauterine inseminationmale infertilityoxidative stresssperm dna fragmentation indexureaplasma urealyticum |
| spellingShingle | Yang-Yang Wan Xiao-Yun Shi Wen-Jing Liu Shun Bai Xin Chen Si-Yao Li Xiao-Hua Jiang Li-Min Wu Xian-Sheng Zhang Juan Hua Associations of Ureaplasma urealyticum infection with male infertility and intrauterine insemination outcomes Asian Journal of Andrology intrauterine insemination male infertility oxidative stress sperm dna fragmentation index ureaplasma urealyticum |
| title | Associations of Ureaplasma urealyticum infection with male infertility and intrauterine insemination outcomes |
| title_full | Associations of Ureaplasma urealyticum infection with male infertility and intrauterine insemination outcomes |
| title_fullStr | Associations of Ureaplasma urealyticum infection with male infertility and intrauterine insemination outcomes |
| title_full_unstemmed | Associations of Ureaplasma urealyticum infection with male infertility and intrauterine insemination outcomes |
| title_short | Associations of Ureaplasma urealyticum infection with male infertility and intrauterine insemination outcomes |
| title_sort | associations of ureaplasma urealyticum infection with male infertility and intrauterine insemination outcomes |
| topic | intrauterine insemination male infertility oxidative stress sperm dna fragmentation index ureaplasma urealyticum |
| url | https://journals.lww.com/10.4103/aja202489 |
| work_keys_str_mv | AT yangyangwan associationsofureaplasmaurealyticuminfectionwithmaleinfertilityandintrauterineinseminationoutcomes AT xiaoyunshi associationsofureaplasmaurealyticuminfectionwithmaleinfertilityandintrauterineinseminationoutcomes AT wenjingliu associationsofureaplasmaurealyticuminfectionwithmaleinfertilityandintrauterineinseminationoutcomes AT shunbai associationsofureaplasmaurealyticuminfectionwithmaleinfertilityandintrauterineinseminationoutcomes AT xinchen associationsofureaplasmaurealyticuminfectionwithmaleinfertilityandintrauterineinseminationoutcomes AT siyaoli associationsofureaplasmaurealyticuminfectionwithmaleinfertilityandintrauterineinseminationoutcomes AT xiaohuajiang associationsofureaplasmaurealyticuminfectionwithmaleinfertilityandintrauterineinseminationoutcomes AT liminwu associationsofureaplasmaurealyticuminfectionwithmaleinfertilityandintrauterineinseminationoutcomes AT xianshengzhang associationsofureaplasmaurealyticuminfectionwithmaleinfertilityandintrauterineinseminationoutcomes AT juanhua associationsofureaplasmaurealyticuminfectionwithmaleinfertilityandintrauterineinseminationoutcomes |