Acute Kidney Injury and Atypical Features during Pediatric Poststreptococcal Glomerulonephritis
The most common acute glomerulonephritis in children is poststreptococcal glomerulonephritis (PSGN) usually occurring between 3 and 12 years old. Hypertension and gross hematuria are common presenting symptoms. Most PSGN patients do not experience complications, but rapidly progressive glomeruloneph...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2016/5163065 |
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| author | Rose M. Ayoob Andrew L. Schwaderer |
| author_facet | Rose M. Ayoob Andrew L. Schwaderer |
| author_sort | Rose M. Ayoob |
| collection | DOAJ |
| description | The most common acute glomerulonephritis in children is poststreptococcal glomerulonephritis (PSGN) usually occurring between 3 and 12 years old. Hypertension and gross hematuria are common presenting symptoms. Most PSGN patients do not experience complications, but rapidly progressive glomerulonephritis and hypertensive encephalopathy have been reported. This paper reports 17 patients seen in 1 year for PSGN including 4 with atypical PSGN, at a pediatric tertiary care center. Seventeen children (11 males), mean age of 8 years, were analyzed. Ninety-four percent had elevated serum BUN levels and decreased GFR. Four of the hospitalized patients had complex presentations that included AKI along with positive ANA or ANCAs. Three patients required renal replacement therapy and two were thrombocytopenic. PSGN usually does not occur as a severe nephritis. Over the 12-month study period, 17 cases associated with low serum albumin in 53%, acute kidney injury in 94%, and thrombocytopenia in 18% were treated. The presentation of PSGN may be severe and in a small subset have associations similar to SLE nephritis findings including AKI, positive ANA, and hematological anomalies. |
| format | Article |
| id | doaj-art-0796f7d6b7ff48b18cae297abf33051b |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-0796f7d6b7ff48b18cae297abf33051b2025-02-03T01:33:08ZengWileyInternational Journal of Nephrology2090-214X2090-21582016-01-01201610.1155/2016/51630655163065Acute Kidney Injury and Atypical Features during Pediatric Poststreptococcal GlomerulonephritisRose M. Ayoob0Andrew L. Schwaderer1Division of Nephrology, Department of Pediatrics, Nationwide Children’s Hospital, Columbus, OH, USADivision of Nephrology, Department of Pediatrics, Nationwide Children’s Hospital, Columbus, OH, USAThe most common acute glomerulonephritis in children is poststreptococcal glomerulonephritis (PSGN) usually occurring between 3 and 12 years old. Hypertension and gross hematuria are common presenting symptoms. Most PSGN patients do not experience complications, but rapidly progressive glomerulonephritis and hypertensive encephalopathy have been reported. This paper reports 17 patients seen in 1 year for PSGN including 4 with atypical PSGN, at a pediatric tertiary care center. Seventeen children (11 males), mean age of 8 years, were analyzed. Ninety-four percent had elevated serum BUN levels and decreased GFR. Four of the hospitalized patients had complex presentations that included AKI along with positive ANA or ANCAs. Three patients required renal replacement therapy and two were thrombocytopenic. PSGN usually does not occur as a severe nephritis. Over the 12-month study period, 17 cases associated with low serum albumin in 53%, acute kidney injury in 94%, and thrombocytopenia in 18% were treated. The presentation of PSGN may be severe and in a small subset have associations similar to SLE nephritis findings including AKI, positive ANA, and hematological anomalies.http://dx.doi.org/10.1155/2016/5163065 |
| spellingShingle | Rose M. Ayoob Andrew L. Schwaderer Acute Kidney Injury and Atypical Features during Pediatric Poststreptococcal Glomerulonephritis International Journal of Nephrology |
| title | Acute Kidney Injury and Atypical Features during Pediatric Poststreptococcal Glomerulonephritis |
| title_full | Acute Kidney Injury and Atypical Features during Pediatric Poststreptococcal Glomerulonephritis |
| title_fullStr | Acute Kidney Injury and Atypical Features during Pediatric Poststreptococcal Glomerulonephritis |
| title_full_unstemmed | Acute Kidney Injury and Atypical Features during Pediatric Poststreptococcal Glomerulonephritis |
| title_short | Acute Kidney Injury and Atypical Features during Pediatric Poststreptococcal Glomerulonephritis |
| title_sort | acute kidney injury and atypical features during pediatric poststreptococcal glomerulonephritis |
| url | http://dx.doi.org/10.1155/2016/5163065 |
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