Nanoparticle albumin-bound paclitaxel – first step of nanotechnology into clinical practice
Paclitaxel is an effective antitumor agent used for treatment of breast cancer, lung, stomach and pancreas. However, its own adverse effects and the use of toxic Cremophor EL as the solvent limit the application range of this drug. Associated with the albumin-bound nanoparticle paclitaxel (paclitaxe...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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Ministry of Health of the Russian Federation, Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products»
2022-06-01
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| Series: | Безопасность и риск фармакотерапии |
| Subjects: | |
| Online Access: | https://www.risksafety.ru/jour/article/view/300 |
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| author | R. N. Alyautdin B. K. Romanov В. К. Лепахин N. D. Bunyatyan V. A. Merkulov A. N. Mironov |
| author_facet | R. N. Alyautdin B. K. Romanov В. К. Лепахин N. D. Bunyatyan V. A. Merkulov A. N. Mironov |
| author_sort | R. N. Alyautdin |
| collection | DOAJ |
| description | Paclitaxel is an effective antitumor agent used for treatment of breast cancer, lung, stomach and pancreas. However, its own adverse effects and the use of toxic Cremophor EL as the solvent limit the application range of this drug. Associated with the albumin-bound nanoparticle paclitaxel (paclitaxel SAN) specifically transported into tumor tissue. This leads to an increase in the antitumor effect, and it reduces the severity of side effects. |
| format | Article |
| id | doaj-art-0790c234e1d34de89f348153b91c9c46 |
| institution | Kabale University |
| issn | 2312-7821 2619-1164 |
| language | Russian |
| publishDate | 2022-06-01 |
| publisher | Ministry of Health of the Russian Federation, Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» |
| record_format | Article |
| series | Безопасность и риск фармакотерапии |
| spelling | doaj-art-0790c234e1d34de89f348153b91c9c462025-08-20T03:43:01ZrusMinistry of Health of the Russian Federation, Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products»Безопасность и риск фармакотерапии2312-78212619-11642022-06-01021016233Nanoparticle albumin-bound paclitaxel – first step of nanotechnology into clinical practiceR. N. Alyautdin0B. K. Romanov1В. К. Лепахин2N. D. Bunyatyan3V. A. Merkulov4A. N. Mironov5Scientific Centre for Expert Evaluation of Medicinal Products Russian FederationScientific Centre for Expert Evaluation of Medicinal Products Russian FederationScientific Centre for Expert Evaluation of Medicinal Products Russian FederationScientific Centre for Expert Evaluation of Medicinal Products Russian FederationScientific Centre for Expert Evaluation of Medicinal Products Russian FederationScientific Centre for Expert Evaluation of Medicinal Products Russian FederationPaclitaxel is an effective antitumor agent used for treatment of breast cancer, lung, stomach and pancreas. However, its own adverse effects and the use of toxic Cremophor EL as the solvent limit the application range of this drug. Associated with the albumin-bound nanoparticle paclitaxel (paclitaxel SAN) specifically transported into tumor tissue. This leads to an increase in the antitumor effect, and it reduces the severity of side effects.https://www.risksafety.ru/jour/article/view/300nanotechnology, albumin nanparticles, paclitaxel |
| spellingShingle | R. N. Alyautdin B. K. Romanov В. К. Лепахин N. D. Bunyatyan V. A. Merkulov A. N. Mironov Nanoparticle albumin-bound paclitaxel – first step of nanotechnology into clinical practice Безопасность и риск фармакотерапии nanotechnology, albumin nanparticles, paclitaxel |
| title | Nanoparticle albumin-bound paclitaxel – first step of nanotechnology into clinical practice |
| title_full | Nanoparticle albumin-bound paclitaxel – first step of nanotechnology into clinical practice |
| title_fullStr | Nanoparticle albumin-bound paclitaxel – first step of nanotechnology into clinical practice |
| title_full_unstemmed | Nanoparticle albumin-bound paclitaxel – first step of nanotechnology into clinical practice |
| title_short | Nanoparticle albumin-bound paclitaxel – first step of nanotechnology into clinical practice |
| title_sort | nanoparticle albumin bound paclitaxel first step of nanotechnology into clinical practice |
| topic | nanotechnology, albumin nanparticles, paclitaxel |
| url | https://www.risksafety.ru/jour/article/view/300 |
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