Bridging the Gap: Supplements Strategies from Experimental Research to Clinical Applications in Sarcopenic Obesity
Obesity causes fat accumulation, and sarcopenia causes loss of muscle mass and strength; together, they worsen insulin resistance and accelerate muscle decline, creating a harmful cycle. Some supplements, along with physical exercise, could be remedies for sarcopenic obesity (SO). In this review, we...
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MDPI AG
2024-11-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/46/12/800 |
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| author | Bogdana Virgolici Maria-Zinaida Dobre Daciana Costina Andrada Stefan |
| author_facet | Bogdana Virgolici Maria-Zinaida Dobre Daciana Costina Andrada Stefan |
| author_sort | Bogdana Virgolici |
| collection | DOAJ |
| description | Obesity causes fat accumulation, and sarcopenia causes loss of muscle mass and strength; together, they worsen insulin resistance and accelerate muscle decline, creating a harmful cycle. Some supplements, along with physical exercise, could be remedies for sarcopenic obesity (SO). In this review, we aim to draw a comparison between supplements studied in experimental research and those evaluated in clinical studies for SO. In experimental studies, Sea Buckthorn—in forms such as oil, freeze-dried powder or pomace—has been shown to enhance muscle cell growth, improve gut microbiota, provide hypoglycemic benefits and increase muscle mass by promoting protein synthesis. Increased consumption of Omega-3 fatty acids may play a protective role against SO in women. Melatonin may positively impact obesity and SO by reducing oxidative stress. Elevated irisin levels, such as those observed with vitamin D supplementation, could prevent muscle wasting and fat gain in SO by improving insulin sensitivity and reducing inflammation. There have been many studies highlighting the potential of vitamin D in preventing age related sarcopenia; however, the effect of vitamin D supplementation in SO is under-researched and appears less promising. Future clinical trials using natural supplements hold promise, as these provide multiple beneficial components that may work synergistically to treat SO. |
| format | Article |
| id | doaj-art-078780fcecce40aeaf109a790f409663 |
| institution | DOAJ |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
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| series | Current Issues in Molecular Biology |
| spelling | doaj-art-078780fcecce40aeaf109a790f4096632025-08-20T02:53:25ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452024-11-014612134181343010.3390/cimb46120800Bridging the Gap: Supplements Strategies from Experimental Research to Clinical Applications in Sarcopenic ObesityBogdana Virgolici0Maria-Zinaida Dobre1Daciana Costina Andrada Stefan2Department of Biochemistry, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Biochemistry, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Biochemistry, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaObesity causes fat accumulation, and sarcopenia causes loss of muscle mass and strength; together, they worsen insulin resistance and accelerate muscle decline, creating a harmful cycle. Some supplements, along with physical exercise, could be remedies for sarcopenic obesity (SO). In this review, we aim to draw a comparison between supplements studied in experimental research and those evaluated in clinical studies for SO. In experimental studies, Sea Buckthorn—in forms such as oil, freeze-dried powder or pomace—has been shown to enhance muscle cell growth, improve gut microbiota, provide hypoglycemic benefits and increase muscle mass by promoting protein synthesis. Increased consumption of Omega-3 fatty acids may play a protective role against SO in women. Melatonin may positively impact obesity and SO by reducing oxidative stress. Elevated irisin levels, such as those observed with vitamin D supplementation, could prevent muscle wasting and fat gain in SO by improving insulin sensitivity and reducing inflammation. There have been many studies highlighting the potential of vitamin D in preventing age related sarcopenia; however, the effect of vitamin D supplementation in SO is under-researched and appears less promising. Future clinical trials using natural supplements hold promise, as these provide multiple beneficial components that may work synergistically to treat SO.https://www.mdpi.com/1467-3045/46/12/800sarcopenic obesity (SO)supplementobesityinsulin resistanceoxidative stressinflammation |
| spellingShingle | Bogdana Virgolici Maria-Zinaida Dobre Daciana Costina Andrada Stefan Bridging the Gap: Supplements Strategies from Experimental Research to Clinical Applications in Sarcopenic Obesity Current Issues in Molecular Biology sarcopenic obesity (SO) supplement obesity insulin resistance oxidative stress inflammation |
| title | Bridging the Gap: Supplements Strategies from Experimental Research to Clinical Applications in Sarcopenic Obesity |
| title_full | Bridging the Gap: Supplements Strategies from Experimental Research to Clinical Applications in Sarcopenic Obesity |
| title_fullStr | Bridging the Gap: Supplements Strategies from Experimental Research to Clinical Applications in Sarcopenic Obesity |
| title_full_unstemmed | Bridging the Gap: Supplements Strategies from Experimental Research to Clinical Applications in Sarcopenic Obesity |
| title_short | Bridging the Gap: Supplements Strategies from Experimental Research to Clinical Applications in Sarcopenic Obesity |
| title_sort | bridging the gap supplements strategies from experimental research to clinical applications in sarcopenic obesity |
| topic | sarcopenic obesity (SO) supplement obesity insulin resistance oxidative stress inflammation |
| url | https://www.mdpi.com/1467-3045/46/12/800 |
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