Effects of practical models of low-volume high-intensity interval training on glycemic control and insulin resistance in adults: a systematic review and meta-analysis of randomized controlled studies
ObjectivesThe aim of this systematic review and meta-analysis was to investigate the effects of practical models of low-volume high-intensity interval training protocols (LV-HIIT) on glucose control and insulin resistance compared with moderate-intensity continuous training (MICT) protocols and no-e...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1481200/full |
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| author | Yining Lu Julien S. Baker Shanshan Ying Yichen Lu |
| author_facet | Yining Lu Julien S. Baker Shanshan Ying Yichen Lu |
| author_sort | Yining Lu |
| collection | DOAJ |
| description | ObjectivesThe aim of this systematic review and meta-analysis was to investigate the effects of practical models of low-volume high-intensity interval training protocols (LV-HIIT) on glucose control and insulin resistance compared with moderate-intensity continuous training (MICT) protocols and no-exercise controls (CON).MethodsFour databases (PubMed, Web of Science, Scopus, and Cochrane Library) were searched for randomized controlled studies conducted using LV-HIIT interventions (HIIT/SIT protocols involving ≤ 15 min of intense training, within a session lasting ≤ 30 min; < 30 s all-out sprint for SIT additionally). The inclusion criteria required glucose and insulin resistance markers to be evaluated pre- and post-intervention among adults who were not trained athletes.ResultsAs a result, twenty studies were included, and meta-analyses were conducted using sixteen studies employing HIIT protocols. Compared with CON, LV-HIIT with reduced intensity and extended interval duration significantly improved fasting glucose (FPG) (mean difference (MD) in mg/dL=-16.63; 95% confidence interval (CI): -25.30 to -7.96; p<0.001) and HbA1c (MD=-0.70; 95% CI: -1.10 to -0.29; p<0.001). Greater improvements were found in participants who were overweight/obese or having type 2 diabetes (T2D). FPG decreased with every additional second of interval duration (β;=-0.10; 95% CI: -0.19 to -0.00; p=0.046). FPI (β;=-0.65; 95% CI: -1.27 to -0.02; p=0.042) and HOMA-IR (β;=-0.22; 95% CI: -0.36 to -0.09; p=0.001) decreased with every additional minute of interval duration per session. HOMA-IR also decreased with every additional minute of weekly interval duration (β;=-0.06; 95%CI: -0.08 to -0.04; p<0.001). Compared with MICT, LV-HIIT was more effective in improving insulin sensitivity (SMD=-0.40; 95%CI: -0.70 to -0.09; p=0.01), but there were no differences in FPG, FPI, HbA1c or HOMA-IR (p>0.05). The effect of LV-HIIT on FPI was larger compared with MICT among individuals who lost weight.ConclusionConclusively, a practical model of LV-HIIT with reduced intensity and extended interval was effective in improving glucose control and its effects were similar to MICT. Greater improvements were found in individuals with overweight/obesity or T2D in protocols with longer intervals or accumulated interval duration per session/week. More large-scale, randomized controlled studies with similar intervention protocols in a wide range of population are warranted to confirm these important results.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42024516594. |
| format | Article |
| id | doaj-art-07816dba256c4cdea1e2b04bda5b2b2b |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-07816dba256c4cdea1e2b04bda5b2b2b2025-01-23T05:10:16ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-01-011610.3389/fendo.2025.14812001481200Effects of practical models of low-volume high-intensity interval training on glycemic control and insulin resistance in adults: a systematic review and meta-analysis of randomized controlled studiesYining Lu0Julien S. Baker1Shanshan Ying2Yichen Lu3Faculty of Sports Science, Ningbo University, Ningbo, ChinaCentre for Population Health and Medical Informatics, Department of Sport, Physical Education and Health, Hong Kong Baptist University, Hong Kong, Hong Kong SAR, ChinaFaculty of Sports Science, Ningbo University, Ningbo, ChinaDepartment of Sport and Physical Education, Zhejiang Pharmaceutical University, Ningbo, ChinaObjectivesThe aim of this systematic review and meta-analysis was to investigate the effects of practical models of low-volume high-intensity interval training protocols (LV-HIIT) on glucose control and insulin resistance compared with moderate-intensity continuous training (MICT) protocols and no-exercise controls (CON).MethodsFour databases (PubMed, Web of Science, Scopus, and Cochrane Library) were searched for randomized controlled studies conducted using LV-HIIT interventions (HIIT/SIT protocols involving ≤ 15 min of intense training, within a session lasting ≤ 30 min; < 30 s all-out sprint for SIT additionally). The inclusion criteria required glucose and insulin resistance markers to be evaluated pre- and post-intervention among adults who were not trained athletes.ResultsAs a result, twenty studies were included, and meta-analyses were conducted using sixteen studies employing HIIT protocols. Compared with CON, LV-HIIT with reduced intensity and extended interval duration significantly improved fasting glucose (FPG) (mean difference (MD) in mg/dL=-16.63; 95% confidence interval (CI): -25.30 to -7.96; p<0.001) and HbA1c (MD=-0.70; 95% CI: -1.10 to -0.29; p<0.001). Greater improvements were found in participants who were overweight/obese or having type 2 diabetes (T2D). FPG decreased with every additional second of interval duration (β;=-0.10; 95% CI: -0.19 to -0.00; p=0.046). FPI (β;=-0.65; 95% CI: -1.27 to -0.02; p=0.042) and HOMA-IR (β;=-0.22; 95% CI: -0.36 to -0.09; p=0.001) decreased with every additional minute of interval duration per session. HOMA-IR also decreased with every additional minute of weekly interval duration (β;=-0.06; 95%CI: -0.08 to -0.04; p<0.001). Compared with MICT, LV-HIIT was more effective in improving insulin sensitivity (SMD=-0.40; 95%CI: -0.70 to -0.09; p=0.01), but there were no differences in FPG, FPI, HbA1c or HOMA-IR (p>0.05). The effect of LV-HIIT on FPI was larger compared with MICT among individuals who lost weight.ConclusionConclusively, a practical model of LV-HIIT with reduced intensity and extended interval was effective in improving glucose control and its effects were similar to MICT. Greater improvements were found in individuals with overweight/obesity or T2D in protocols with longer intervals or accumulated interval duration per session/week. More large-scale, randomized controlled studies with similar intervention protocols in a wide range of population are warranted to confirm these important results.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42024516594.https://www.frontiersin.org/articles/10.3389/fendo.2025.1481200/fullpractical modellow-volumehigh-intensity interval trainingglucoseinsulin resistance |
| spellingShingle | Yining Lu Julien S. Baker Shanshan Ying Yichen Lu Effects of practical models of low-volume high-intensity interval training on glycemic control and insulin resistance in adults: a systematic review and meta-analysis of randomized controlled studies Frontiers in Endocrinology practical model low-volume high-intensity interval training glucose insulin resistance |
| title | Effects of practical models of low-volume high-intensity interval training on glycemic control and insulin resistance in adults: a systematic review and meta-analysis of randomized controlled studies |
| title_full | Effects of practical models of low-volume high-intensity interval training on glycemic control and insulin resistance in adults: a systematic review and meta-analysis of randomized controlled studies |
| title_fullStr | Effects of practical models of low-volume high-intensity interval training on glycemic control and insulin resistance in adults: a systematic review and meta-analysis of randomized controlled studies |
| title_full_unstemmed | Effects of practical models of low-volume high-intensity interval training on glycemic control and insulin resistance in adults: a systematic review and meta-analysis of randomized controlled studies |
| title_short | Effects of practical models of low-volume high-intensity interval training on glycemic control and insulin resistance in adults: a systematic review and meta-analysis of randomized controlled studies |
| title_sort | effects of practical models of low volume high intensity interval training on glycemic control and insulin resistance in adults a systematic review and meta analysis of randomized controlled studies |
| topic | practical model low-volume high-intensity interval training glucose insulin resistance |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1481200/full |
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