Advances in the roles and mechanisms of mesenchymal stem cell derived microRNAs on periodontal tissue regeneration
Abstract Periodontitis is one of the most prevalent oral diseases leading to tooth loss in adults, and is characterized by the destruction of periodontal supporting structures. Traditional therapies for periodontitis cannot achieve ideal regeneration of the periodontal tissue. Mesenchymal stem cells...
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BMC
2024-11-01
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| Series: | Stem Cell Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13287-024-03998-5 |
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| author | Jiaxiang Zhang Liangrui Chen Jialu Yu Weidong Tian Shujuan Guo |
| author_facet | Jiaxiang Zhang Liangrui Chen Jialu Yu Weidong Tian Shujuan Guo |
| author_sort | Jiaxiang Zhang |
| collection | DOAJ |
| description | Abstract Periodontitis is one of the most prevalent oral diseases leading to tooth loss in adults, and is characterized by the destruction of periodontal supporting structures. Traditional therapies for periodontitis cannot achieve ideal regeneration of the periodontal tissue. Mesenchymal stem cells (MSCs) represent a promising approach to periodontal tissue regeneration. Recently, the prominent role of MSCs in this context has been attributed to microRNAs (miRNAs), which participate in post-transcriptional regulation and are crucial for various physiological and pathological processes. Additionally, they function as indispensable elements in extracellular vesicles, which protect them from degradation. In periodontitis, MSCs-derived miRNAs play a pivotal role in cellular proliferation and differentiation, angiogenesis of periodontal tissues, regulating autophagy, providing anti-apoptotic effects, and mediating the inflammatory microenvironment. As a cell-free strategy, their small size and ability to target related sets of genes and regulate signaling networks predispose miRNAs to become ideal candidates for periodontal tissue regeneration. This review aims to introduce and summarize the potential functions and mechanisms of MSCs-derived miRNAs in periodontal tissue repair and regeneration. Graphical Abstract |
| format | Article |
| id | doaj-art-07784ccbae5240efa9c9707789bbe885 |
| institution | OA Journals |
| issn | 1757-6512 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj-art-07784ccbae5240efa9c9707789bbe8852025-08-20T02:13:27ZengBMCStem Cell Research & Therapy1757-65122024-11-0115111810.1186/s13287-024-03998-5Advances in the roles and mechanisms of mesenchymal stem cell derived microRNAs on periodontal tissue regenerationJiaxiang Zhang0Liangrui Chen1Jialu Yu2Weidong Tian3Shujuan Guo4State Key Laboratory of Oral Diseases &National Clinical Research Center for Oral Diseases & Engineering Research Center of Oral Translational Medicine, Ministry of Education & National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases &National Clinical Research Center for Oral Diseases & Engineering Research Center of Oral Translational Medicine, Ministry of Education & National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases &National Clinical Research Center for Oral Diseases & Engineering Research Center of Oral Translational Medicine, Ministry of Education & National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases &National Clinical Research Center for Oral Diseases & Engineering Research Center of Oral Translational Medicine, Ministry of Education & National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases &National Clinical Research Center for Oral Diseases & Engineering Research Center of Oral Translational Medicine, Ministry of Education & National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan UniversityAbstract Periodontitis is one of the most prevalent oral diseases leading to tooth loss in adults, and is characterized by the destruction of periodontal supporting structures. Traditional therapies for periodontitis cannot achieve ideal regeneration of the periodontal tissue. Mesenchymal stem cells (MSCs) represent a promising approach to periodontal tissue regeneration. Recently, the prominent role of MSCs in this context has been attributed to microRNAs (miRNAs), which participate in post-transcriptional regulation and are crucial for various physiological and pathological processes. Additionally, they function as indispensable elements in extracellular vesicles, which protect them from degradation. In periodontitis, MSCs-derived miRNAs play a pivotal role in cellular proliferation and differentiation, angiogenesis of periodontal tissues, regulating autophagy, providing anti-apoptotic effects, and mediating the inflammatory microenvironment. As a cell-free strategy, their small size and ability to target related sets of genes and regulate signaling networks predispose miRNAs to become ideal candidates for periodontal tissue regeneration. This review aims to introduce and summarize the potential functions and mechanisms of MSCs-derived miRNAs in periodontal tissue repair and regeneration. Graphical Abstracthttps://doi.org/10.1186/s13287-024-03998-5Mesenchymal stem cellsMicroRNAExtracellular vesiclesPeriodontitisPeriodontal tissue regeneration |
| spellingShingle | Jiaxiang Zhang Liangrui Chen Jialu Yu Weidong Tian Shujuan Guo Advances in the roles and mechanisms of mesenchymal stem cell derived microRNAs on periodontal tissue regeneration Stem Cell Research & Therapy Mesenchymal stem cells MicroRNA Extracellular vesicles Periodontitis Periodontal tissue regeneration |
| title | Advances in the roles and mechanisms of mesenchymal stem cell derived microRNAs on periodontal tissue regeneration |
| title_full | Advances in the roles and mechanisms of mesenchymal stem cell derived microRNAs on periodontal tissue regeneration |
| title_fullStr | Advances in the roles and mechanisms of mesenchymal stem cell derived microRNAs on periodontal tissue regeneration |
| title_full_unstemmed | Advances in the roles and mechanisms of mesenchymal stem cell derived microRNAs on periodontal tissue regeneration |
| title_short | Advances in the roles and mechanisms of mesenchymal stem cell derived microRNAs on periodontal tissue regeneration |
| title_sort | advances in the roles and mechanisms of mesenchymal stem cell derived micrornas on periodontal tissue regeneration |
| topic | Mesenchymal stem cells MicroRNA Extracellular vesicles Periodontitis Periodontal tissue regeneration |
| url | https://doi.org/10.1186/s13287-024-03998-5 |
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