Reproductive Outcomes of Transferring Blastocysts Derived From Frozen–Thawed Cleavage Embryos: A Systematic Review and Meta‐Analysis
ABSTRACT Background In in vitro fertilization (IVF), transferring frozen–thawed blastocysts is a widely adopted practice. This meta‐analysis aims to evaluate the reproductive outcomes of transferring blastocysts derived from frozen–thawed cleavage embryos (FT‐CDB group) compared to direct frozen–tha...
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| Format: | Article |
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Wiley
2025-01-01
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| Series: | Reproductive Medicine and Biology |
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| Online Access: | https://doi.org/10.1002/rmb2.12673 |
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| author | Huy Phuong Tran Nam Nhat Nguyen Ngoc Thanh Truong Tuyet Thi‐Diem Hoang Trang Nguyen‐Khanh Huynh Ha Le‐Bao Tran |
| author_facet | Huy Phuong Tran Nam Nhat Nguyen Ngoc Thanh Truong Tuyet Thi‐Diem Hoang Trang Nguyen‐Khanh Huynh Ha Le‐Bao Tran |
| author_sort | Huy Phuong Tran |
| collection | DOAJ |
| description | ABSTRACT Background In in vitro fertilization (IVF), transferring frozen–thawed blastocysts is a widely adopted practice. This meta‐analysis aims to evaluate the reproductive outcomes of transferring blastocysts derived from frozen–thawed cleavage embryos (FT‐CDB group) compared to direct frozen–thawed blastocyst (DFB group) transfers. Methods We searched the following electronic databases for relevant studies: PubMed/MEDLINE, EMBASE, Scopus, and Web of Science. Studies were included if they compared the clinical and neonatal outcomes of IVF patients receiving either FT‐CDB or DFB transfer with vitrification method. The protocol for this review has been registered in PROSPERO. Results A total of seven studies (2057 patients) were included in the analysis. Participants in the FT‐CDB group demonstrated significantly higher odds of achieving clinical pregnancy (OR 1.24, 95% CI 1.03–1.49, p = 0.022, I2 = 27%), and live birth (OR 1.31, 95% CI 1.08–1.60, p = 0.007, I2 = 0%) compared to the DFB group. No significant differences were observed in the birth weights of infants between the groups (MD −87.05 g, 95% CI −293.77 to 119.67, p = 0.41, I2 = 83%). Conclusion Transferring blastocysts derived from frozen–thawed cleavage embryos is associated with higher odds of clinical pregnancy and live birth compared to frozen–thawed blastocyst transfers. Trial Registration PROSPERO number: CRD42024591620 |
| format | Article |
| id | doaj-art-0772934fc59349bcb01b309b80e8e50e |
| institution | Kabale University |
| issn | 1445-5781 1447-0578 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
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| series | Reproductive Medicine and Biology |
| spelling | doaj-art-0772934fc59349bcb01b309b80e8e50e2025-08-20T06:16:47ZengWileyReproductive Medicine and Biology1445-57811447-05782025-01-01241n/an/a10.1002/rmb2.12673Reproductive Outcomes of Transferring Blastocysts Derived From Frozen–Thawed Cleavage Embryos: A Systematic Review and Meta‐AnalysisHuy Phuong Tran0Nam Nhat Nguyen1Ngoc Thanh Truong2Tuyet Thi‐Diem Hoang3Trang Nguyen‐Khanh Huynh4Ha Le‐Bao Tran5Faculty of Biology and Biotechnology University of Science Ho Chi Minh City VietnamEndocrinology Clinic Hanh Phuc International Hospital Thuận An Binh Duong VietnamHung Vuong Hospital Ho Chi Minh City VietnamHung Vuong Hospital Ho Chi Minh City VietnamDepartment of Obstetrics and Gynecology Pham Ngoc Thach University of Medicine Ho Chi Minh City VietnamFaculty of Biology and Biotechnology University of Science Ho Chi Minh City VietnamABSTRACT Background In in vitro fertilization (IVF), transferring frozen–thawed blastocysts is a widely adopted practice. This meta‐analysis aims to evaluate the reproductive outcomes of transferring blastocysts derived from frozen–thawed cleavage embryos (FT‐CDB group) compared to direct frozen–thawed blastocyst (DFB group) transfers. Methods We searched the following electronic databases for relevant studies: PubMed/MEDLINE, EMBASE, Scopus, and Web of Science. Studies were included if they compared the clinical and neonatal outcomes of IVF patients receiving either FT‐CDB or DFB transfer with vitrification method. The protocol for this review has been registered in PROSPERO. Results A total of seven studies (2057 patients) were included in the analysis. Participants in the FT‐CDB group demonstrated significantly higher odds of achieving clinical pregnancy (OR 1.24, 95% CI 1.03–1.49, p = 0.022, I2 = 27%), and live birth (OR 1.31, 95% CI 1.08–1.60, p = 0.007, I2 = 0%) compared to the DFB group. No significant differences were observed in the birth weights of infants between the groups (MD −87.05 g, 95% CI −293.77 to 119.67, p = 0.41, I2 = 83%). Conclusion Transferring blastocysts derived from frozen–thawed cleavage embryos is associated with higher odds of clinical pregnancy and live birth compared to frozen–thawed blastocyst transfers. Trial Registration PROSPERO number: CRD42024591620https://doi.org/10.1002/rmb2.12673blastocystcleavage embryofrozen–thawed embryo transferIVF |
| spellingShingle | Huy Phuong Tran Nam Nhat Nguyen Ngoc Thanh Truong Tuyet Thi‐Diem Hoang Trang Nguyen‐Khanh Huynh Ha Le‐Bao Tran Reproductive Outcomes of Transferring Blastocysts Derived From Frozen–Thawed Cleavage Embryos: A Systematic Review and Meta‐Analysis Reproductive Medicine and Biology blastocyst cleavage embryo frozen–thawed embryo transfer IVF |
| title | Reproductive Outcomes of Transferring Blastocysts Derived From Frozen–Thawed Cleavage Embryos: A Systematic Review and Meta‐Analysis |
| title_full | Reproductive Outcomes of Transferring Blastocysts Derived From Frozen–Thawed Cleavage Embryos: A Systematic Review and Meta‐Analysis |
| title_fullStr | Reproductive Outcomes of Transferring Blastocysts Derived From Frozen–Thawed Cleavage Embryos: A Systematic Review and Meta‐Analysis |
| title_full_unstemmed | Reproductive Outcomes of Transferring Blastocysts Derived From Frozen–Thawed Cleavage Embryos: A Systematic Review and Meta‐Analysis |
| title_short | Reproductive Outcomes of Transferring Blastocysts Derived From Frozen–Thawed Cleavage Embryos: A Systematic Review and Meta‐Analysis |
| title_sort | reproductive outcomes of transferring blastocysts derived from frozen thawed cleavage embryos a systematic review and meta analysis |
| topic | blastocyst cleavage embryo frozen–thawed embryo transfer IVF |
| url | https://doi.org/10.1002/rmb2.12673 |
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