AI-assisted Total Body Dermoscopic Evaluation of Changes in Melanocytic Nevi during Pregnancy: A Prospective, Comparative Study of 2,799 Nevi
Pregnancy-associated changes in melanocytic nevi (MN), apart from size increase on the trunk, remain a topic of debate. We conducted the first prospective study to investigate dermoscopic changes in MN comparing pregnant with non-pregnant women on all body parts using a market-approved convolutional...
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Medical Journals Sweden
2025-01-01
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| Series: | Acta Dermato-Venereologica |
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| Online Access: | https://medicaljournalssweden.se/actadv/article/view/41025 |
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| author | Jelissa K. Peter Fabrice Helfenstein Sara E. Cerminara Julia-Tatjana Maul Mara L. Zehnder Dagmar Jamiolkowski Elisabeth Roider Beda Mühleisen Irene Hösli Alexander A. Navarini Lara V. Maul |
| author_facet | Jelissa K. Peter Fabrice Helfenstein Sara E. Cerminara Julia-Tatjana Maul Mara L. Zehnder Dagmar Jamiolkowski Elisabeth Roider Beda Mühleisen Irene Hösli Alexander A. Navarini Lara V. Maul |
| author_sort | Jelissa K. Peter |
| collection | DOAJ |
| description | Pregnancy-associated changes in melanocytic nevi (MN), apart from size increase on the trunk, remain a topic of debate. We conducted the first prospective study to investigate dermoscopic changes in MN comparing pregnant with non-pregnant women on all body parts using a market-approved convolutional neural network (CNN). We included 25 pregnant and 25 non-pregnant women from Basel, Switzerland, who underwent standard skin cancer screenings and whose MN > 2 mm were digitally recorded and analysed by a CNN. Pregnant women were examined three times: in the first and third trimester and 8–12 weeks postpartum; non-pregnant women twice in an interval of 17–21 weeks. We analysed 2,799 MN. In pregnant women, diameter[p < 0.001], area[p < 0.001], number of colours [p = 0.009], shape asymmetry[p = 0.005] and border sharpness[p = 0.006] (inversely proportional value) increased while ellipseness [p < 0.001] decreased from first trimester to postpartum. Changes occurred mainly during the third trimester to postpartum. Compared to non-pregnant women (only first to third trimester) MN on the upper extremities of pregnant women increased in area[p = 0.011] and diameter[p = 0.025] and decreased in ellipseness[p = 0.037]. MN on the lower extremities increased in area[p = 0.044] and MN on the back increased in colour asymmetry[p = 0.022].
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| id | doaj-art-076e97b203fc4161a65957eed62df1d9 |
| institution | Kabale University |
| issn | 0001-5555 1651-2057 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Dermato-Venereologica |
| spelling | doaj-art-076e97b203fc4161a65957eed62df1d92025-01-03T08:46:04ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572025-01-0110510.2340/actadv.v105.41025AI-assisted Total Body Dermoscopic Evaluation of Changes in Melanocytic Nevi during Pregnancy: A Prospective, Comparative Study of 2,799 NeviJelissa K. Peter0Fabrice Helfenstein1Sara E. Cerminara2Julia-Tatjana Maul3Mara L. Zehnder4Dagmar Jamiolkowski5Elisabeth Roider6Beda Mühleisen7Irene Hösli8Alexander A. Navarini9Lara V. Maul10Department of Dermatology, University Hospital of Basel, Basel, SwitzerlandClinical Trials Unit, University of Bern, Bern, Switzerland Department of Dermatology, University Hospital of Basel, Basel, SwitzerlandDepartment of Dermatology, University Hospital of Zurich, Zurich, Switzerland; Faculty of Medicine, University of Zurich, Zurich, SwitzerlandDepartment of Dermatology, University Hospital of Basel, Basel, SwitzerlandDepartment of Dermatology, University Hospital of Basel, Basel, Switzerland; Department of Pediatric Dermatology and Allergology, Children’s Hospital Auf der Bult, Hannover, GermanyDepartment of Dermatology, University Hospital of Basel, Basel, Switzerland; Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USADepartment of Dermatology, University Hospital of Basel, Basel, SwitzerlandDepartment of Obstetrics and Gynecology, University Hospital Basel, Basel, SwitzerlanDepartment of Dermatology, University Hospital of Basel, Basel, SwitzerlandDepartment of Dermatology, University Hospital of Basel, Basel, Switzerland; Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland; Faculty of Medicine, University of Zurich, Zurich, SwitzerlandPregnancy-associated changes in melanocytic nevi (MN), apart from size increase on the trunk, remain a topic of debate. We conducted the first prospective study to investigate dermoscopic changes in MN comparing pregnant with non-pregnant women on all body parts using a market-approved convolutional neural network (CNN). We included 25 pregnant and 25 non-pregnant women from Basel, Switzerland, who underwent standard skin cancer screenings and whose MN > 2 mm were digitally recorded and analysed by a CNN. Pregnant women were examined three times: in the first and third trimester and 8–12 weeks postpartum; non-pregnant women twice in an interval of 17–21 weeks. We analysed 2,799 MN. In pregnant women, diameter[p < 0.001], area[p < 0.001], number of colours [p = 0.009], shape asymmetry[p = 0.005] and border sharpness[p = 0.006] (inversely proportional value) increased while ellipseness [p < 0.001] decreased from first trimester to postpartum. Changes occurred mainly during the third trimester to postpartum. Compared to non-pregnant women (only first to third trimester) MN on the upper extremities of pregnant women increased in area[p = 0.011] and diameter[p = 0.025] and decreased in ellipseness[p = 0.037]. MN on the lower extremities increased in area[p = 0.044] and MN on the back increased in colour asymmetry[p = 0.022]. https://medicaljournalssweden.se/actadv/article/view/41025Artificial intelligenceDigital ImagingMelanocytic neviMelanomaPregnancy |
| spellingShingle | Jelissa K. Peter Fabrice Helfenstein Sara E. Cerminara Julia-Tatjana Maul Mara L. Zehnder Dagmar Jamiolkowski Elisabeth Roider Beda Mühleisen Irene Hösli Alexander A. Navarini Lara V. Maul AI-assisted Total Body Dermoscopic Evaluation of Changes in Melanocytic Nevi during Pregnancy: A Prospective, Comparative Study of 2,799 Nevi Acta Dermato-Venereologica Artificial intelligence Digital Imaging Melanocytic nevi Melanoma Pregnancy |
| title | AI-assisted Total Body Dermoscopic Evaluation of Changes in Melanocytic Nevi during Pregnancy: A Prospective, Comparative Study of 2,799 Nevi |
| title_full | AI-assisted Total Body Dermoscopic Evaluation of Changes in Melanocytic Nevi during Pregnancy: A Prospective, Comparative Study of 2,799 Nevi |
| title_fullStr | AI-assisted Total Body Dermoscopic Evaluation of Changes in Melanocytic Nevi during Pregnancy: A Prospective, Comparative Study of 2,799 Nevi |
| title_full_unstemmed | AI-assisted Total Body Dermoscopic Evaluation of Changes in Melanocytic Nevi during Pregnancy: A Prospective, Comparative Study of 2,799 Nevi |
| title_short | AI-assisted Total Body Dermoscopic Evaluation of Changes in Melanocytic Nevi during Pregnancy: A Prospective, Comparative Study of 2,799 Nevi |
| title_sort | ai assisted total body dermoscopic evaluation of changes in melanocytic nevi during pregnancy a prospective comparative study of 2 799 nevi |
| topic | Artificial intelligence Digital Imaging Melanocytic nevi Melanoma Pregnancy |
| url | https://medicaljournalssweden.se/actadv/article/view/41025 |
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