Synthesis of 4-(2-Methylthiazol-4-yl)-Hexahydroquinoline and 1,4-Dihydropyrimidin Derivatives
A series of new hexahydroquinoline and 1,4-dihydropyrimidine derivatives were synthesized. Condensation of 2-methyl- thiazole-4-carboxaldehyde (1) with 1,3-cyclohexanedione and alkyl 3- aminocrotonate afforded 4-(2-methyl-thiazol-4-yl)-hexahydroquinoline while condensation of aldehyde (1) with benzo...
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| Format: | Article |
| Language: | English |
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University of Tehran
2011-03-01
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| Series: | Journal of Sciences, Islamic Republic of Iran |
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| Online Access: | https://jsciences.ut.ac.ir/article_22210_367bc4ef3a59bbf8a460065a4aa63967.pdf |
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| author | A. Shafiee |
| author_facet | A. Shafiee |
| author_sort | A. Shafiee |
| collection | DOAJ |
| description | A series of new hexahydroquinoline and 1,4-dihydropyrimidine derivatives were synthesized. Condensation of 2-methyl- thiazole-4-carboxaldehyde (1) with 1,3-cyclohexanedione and alkyl 3- aminocrotonate afforded 4-(2-methyl-thiazol-4-yl)-hexahydroquinoline while condensation of aldehyde (1) with benzoyl acetone and thiourea gave 1,4-dihydropyrimidine derivatives. The stereochemistry of 1,4-dihydropyrimidine derivatives were studied using 1HNMR. |
| format | Article |
| id | doaj-art-076bf663d04f4cbc9bac9b9713a37900 |
| institution | Kabale University |
| issn | 1016-1104 2345-6914 |
| language | English |
| publishDate | 2011-03-01 |
| publisher | University of Tehran |
| record_format | Article |
| series | Journal of Sciences, Islamic Republic of Iran |
| spelling | doaj-art-076bf663d04f4cbc9bac9b9713a379002025-08-20T03:53:51ZengUniversity of TehranJournal of Sciences, Islamic Republic of Iran1016-11042345-69142011-03-01221214522210Synthesis of 4-(2-Methylthiazol-4-yl)-Hexahydroquinoline and 1,4-Dihydropyrimidin DerivativesA. Shafiee0Tehran University of Medical SciencesA series of new hexahydroquinoline and 1,4-dihydropyrimidine derivatives were synthesized. Condensation of 2-methyl- thiazole-4-carboxaldehyde (1) with 1,3-cyclohexanedione and alkyl 3- aminocrotonate afforded 4-(2-methyl-thiazol-4-yl)-hexahydroquinoline while condensation of aldehyde (1) with benzoyl acetone and thiourea gave 1,4-dihydropyrimidine derivatives. The stereochemistry of 1,4-dihydropyrimidine derivatives were studied using 1HNMR.https://jsciences.ut.ac.ir/article_22210_367bc4ef3a59bbf8a460065a4aa63967.pdf14-dihydropyrimidines4-hexahydroquinolinethiazoles1-4-dihydropyridine |
| spellingShingle | A. Shafiee Synthesis of 4-(2-Methylthiazol-4-yl)-Hexahydroquinoline and 1,4-Dihydropyrimidin Derivatives Journal of Sciences, Islamic Republic of Iran 1 4-dihydropyrimidines 4-hexahydroquinoline thiazoles 1-4-dihydropyridine |
| title | Synthesis of 4-(2-Methylthiazol-4-yl)-Hexahydroquinoline and 1,4-Dihydropyrimidin Derivatives |
| title_full | Synthesis of 4-(2-Methylthiazol-4-yl)-Hexahydroquinoline and 1,4-Dihydropyrimidin Derivatives |
| title_fullStr | Synthesis of 4-(2-Methylthiazol-4-yl)-Hexahydroquinoline and 1,4-Dihydropyrimidin Derivatives |
| title_full_unstemmed | Synthesis of 4-(2-Methylthiazol-4-yl)-Hexahydroquinoline and 1,4-Dihydropyrimidin Derivatives |
| title_short | Synthesis of 4-(2-Methylthiazol-4-yl)-Hexahydroquinoline and 1,4-Dihydropyrimidin Derivatives |
| title_sort | synthesis of 4 2 methylthiazol 4 yl hexahydroquinoline and 1 4 dihydropyrimidin derivatives |
| topic | 1 4-dihydropyrimidines 4-hexahydroquinoline thiazoles 1-4-dihydropyridine |
| url | https://jsciences.ut.ac.ir/article_22210_367bc4ef3a59bbf8a460065a4aa63967.pdf |
| work_keys_str_mv | AT ashafiee synthesisof42methylthiazol4ylhexahydroquinolineand14dihydropyrimidinderivatives |