Optimized Enoxolone-Loaded Microsponges for Drug Delivery: A Design of Experiments Approach
Enoxolon is widely recognized for its pharmacological potential, exhibiting antioxidant, anti-inflammatory, anticancer, and antiviral properties. <b>Objectives</b>: This study aimed to develop an enhanced formulation of enoxolone-loaded microsponges as a novel drug delivery system. A des...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-06-01
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| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/18/7/938 |
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| Summary: | Enoxolon is widely recognized for its pharmacological potential, exhibiting antioxidant, anti-inflammatory, anticancer, and antiviral properties. <b>Objectives</b>: This study aimed to develop an enhanced formulation of enoxolone-loaded microsponges as a novel drug delivery system. A design of experiments (DoE) approach was employed for the optimization process. <b>Methods</b>: The microsponges were produced using the <i>quasi</i>-emulsion technique. The selected formulation was evaluated for yield, particle size, and entrapment efficiency. Furthermore, the microsponges were incorporated into a 1% MC solution matrix, and in vitro release studies were performed to assess their drug delivery performance. <b>Results</b>: The optimal formulation was determined through the DoE methodology, which involved varying the concentrations of methylcellulose (MC) (0.55–1.87%, <i>w</i>/<i>w</i>), polyvinyl alcohol (PVA) (0.5–1%, <i>w</i>/<i>w</i>), and Tween 80 (TW80) (1.5–2.5%, <i>w</i>/<i>w</i>). The results showed a particle size of 142.8 ± 10.02 µm and an entrapment efficiency of 80.3 ± 1.99%. When comparing the optimized microsponge formulation to pure enoxolon, a 1.29 times higher release rate was observed (<i>p</i> ≤ 0.05). <b>Conclusions</b>: Following optimizationand physicochemical characterization studies were conducted to further assess the formulation. These findings suggest that microsponge-based delivery systems hold considerable potential as an alternative platform for the topical treatment of chronic periodontitis. |
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| ISSN: | 1424-8247 |