Treating a Metastatic Pericardial Tumor
Background: Pericardial involvement of metastatic adenocarcinoma is rare, and its treatment has historically involved several strategies. Case Summary: We describe a case of pericardial metastasis from gastrointestinal adenocarcinoma presenting with pericardial syndrome of effusive-constrictive peri...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-07-01
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| Series: | JACC: Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266608492500645X |
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| author | Leslie A. Ynalvez, MD Cezar A. Iliescu, MD Ihab R. Hamzeh, MD Anita Deswal, MD, MPH Nicolas L. Palaskas, MD |
| author_facet | Leslie A. Ynalvez, MD Cezar A. Iliescu, MD Ihab R. Hamzeh, MD Anita Deswal, MD, MPH Nicolas L. Palaskas, MD |
| author_sort | Leslie A. Ynalvez, MD |
| collection | DOAJ |
| description | Background: Pericardial involvement of metastatic adenocarcinoma is rare, and its treatment has historically involved several strategies. Case Summary: We describe a case of pericardial metastasis from gastrointestinal adenocarcinoma presenting with pericardial syndrome of effusive-constrictive pericarditis (ECP), managed with pericardiocentesis and drain placement followed by 10 cycles of systemic chemotherapy, leading to the resolution of pericardial disease and improved quality of life. Discussion: Treatment strategies for malignant ECP in lieu of pericardiectomy have included pericardiocentesis only or pericardiocentesis with chemotherapy (either local, systemic, or both). Our approach at MD Anderson Cancer Center is to perform pericardiocentesis with temporary pericardial drain placement to decrease reaccumulation rate, followed by systemic chemotherapy to reduce pericardial tumor infiltration but limit sclerosing effect. Take-Home Message: The combination of pericardiocentesis with drain placement for 3 to 5 days postpericardiocentesis followed by systemic chemotherapy can be a successful treatment strategy in ECP due to metastatic pericardial disease. |
| format | Article |
| id | doaj-art-07670501e9664facbf0995526efbe19a |
| institution | DOAJ |
| issn | 2666-0849 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JACC: Case Reports |
| spelling | doaj-art-07670501e9664facbf0995526efbe19a2025-08-20T03:16:10ZengElsevierJACC: Case Reports2666-08492025-07-01301710386710.1016/j.jaccas.2025.103867Treating a Metastatic Pericardial TumorLeslie A. Ynalvez, MD0Cezar A. Iliescu, MD1Ihab R. Hamzeh, MD2Anita Deswal, MD, MPH3Nicolas L. Palaskas, MD4Address for correspondence: Dr Leslie A. Ynalvez, Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.; Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USADepartment of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USADepartment of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USADepartment of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USADepartment of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USABackground: Pericardial involvement of metastatic adenocarcinoma is rare, and its treatment has historically involved several strategies. Case Summary: We describe a case of pericardial metastasis from gastrointestinal adenocarcinoma presenting with pericardial syndrome of effusive-constrictive pericarditis (ECP), managed with pericardiocentesis and drain placement followed by 10 cycles of systemic chemotherapy, leading to the resolution of pericardial disease and improved quality of life. Discussion: Treatment strategies for malignant ECP in lieu of pericardiectomy have included pericardiocentesis only or pericardiocentesis with chemotherapy (either local, systemic, or both). Our approach at MD Anderson Cancer Center is to perform pericardiocentesis with temporary pericardial drain placement to decrease reaccumulation rate, followed by systemic chemotherapy to reduce pericardial tumor infiltration but limit sclerosing effect. Take-Home Message: The combination of pericardiocentesis with drain placement for 3 to 5 days postpericardiocentesis followed by systemic chemotherapy can be a successful treatment strategy in ECP due to metastatic pericardial disease.http://www.sciencedirect.com/science/article/pii/S266608492500645Xcancerconstrictiveechocardiographypericardial effusiontamponade |
| spellingShingle | Leslie A. Ynalvez, MD Cezar A. Iliescu, MD Ihab R. Hamzeh, MD Anita Deswal, MD, MPH Nicolas L. Palaskas, MD Treating a Metastatic Pericardial Tumor JACC: Case Reports cancer constrictive echocardiography pericardial effusion tamponade |
| title | Treating a Metastatic Pericardial Tumor |
| title_full | Treating a Metastatic Pericardial Tumor |
| title_fullStr | Treating a Metastatic Pericardial Tumor |
| title_full_unstemmed | Treating a Metastatic Pericardial Tumor |
| title_short | Treating a Metastatic Pericardial Tumor |
| title_sort | treating a metastatic pericardial tumor |
| topic | cancer constrictive echocardiography pericardial effusion tamponade |
| url | http://www.sciencedirect.com/science/article/pii/S266608492500645X |
| work_keys_str_mv | AT leslieaynalvezmd treatingametastaticpericardialtumor AT cezarailiescumd treatingametastaticpericardialtumor AT ihabrhamzehmd treatingametastaticpericardialtumor AT anitadeswalmdmph treatingametastaticpericardialtumor AT nicolaslpalaskasmd treatingametastaticpericardialtumor |